Search Results - "Bénard, François"

Journal Article

Bench to Bedside: Albumin Binders for Improved Cancer Radioligand Therapies

by Lau, Joseph Jacobson, Orit Niu, Gang Lin, Kuo-Shyan Bénard, François Chen, Xiaoyuan Published in Bioconjugate chemistry (20.03.2019)

“...Radioligand therapy (RLT) relies on the use of pharmacophores to selectively deliver ionization energy to cancers to exert its tumoricidal effects. Cancer...”

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Journal Article

18F-5-Fluoroaminosuberic Acid as a Potential Tracer to Gauge Oxidative Stress in Breast Cancer Models

by Yang, Hua Jenni, Silvia Colovic, Milena Merkens, Helen Poleschuk, Carlee Rodrigo, Isabel Miao, Qing Johnson, Bruce F Rishel, Michael J Sossi, Vesna Webster, Jack M Bénard, François Schaffer, Paul Published in The Journal of nuclear medicine (1978) (01.03.2017)

“...The cystine transporter (system xC-) is an antiporter of cystine and glutamate. It has relatively low basal expression in most tissues and becomes upregulated...”

Journal Article

The Effect of Chirality on the Application of 5-[18F]Fluoro-Aminosuberic Acid ([18F]FASu) for Oxidative Stress Imaging

by Čolović, Milena Yang, Hua Merkens, Helen Colpo, Nadine Bénard, François Schaffer, Paul Published in Molecular imaging and biology (01.08.2020)

“...PURPOSEThe cystine transporter, system xC-, plays a crucial role in sustaining redox homeostasis and is reported to be overexpressed in several cancer...”

Journal Article

Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics

by Yuan, Zheliang Yang, Hua Malik, Noeen Čolović, Milena Weber, David S Wilson, Darryl Bénard, François Martin, Rainer E Warren, Jeffrey J Schaffer, Paul Britton, Robert Published in ACS catalysis (06.09.2019)

“...The site-selective fluorination of unactivated C(sp3)-H bonds provides unique opportunities to rapidly alter drug properties or generate radiotracers for...”

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Journal Article

[nat/44Sc(pypa)]−: Thermodynamic Stability, Radiolabeling, and Biodistribution of a Prostate-Specific-Membrane-Antigen-Targeting Conjugate

by Li, Lily Jaraquemada-Peláez, María de Guadalupe Aluicio-Sarduy, Eduardo Wang, Xiaozhu Jiang, Dawei Sakheie, Meelad Kuo, Hsiou-Ting Barnhart, Todd E Cai, Weibo Radchenko, Valery Schaffer, Paul Lin, Kuo-Shyan Engle, Jonathan W Bénard, François Orvig, Chris Published in Inorganic chemistry (03.02.2020)

“...44Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc3+ ion with nonmacrocyclic chelator H4pypa was synthesized...”

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Journal Article

Enhancing Treatment Efficacy of 177Lu-PSMA-617 with the Conjugation of an Albumin-Binding Motif: Preclinical Dosimetry and Endoradiotherapy Studies

by Kuo, Hsiou-Ting Merkens, Helen Zhang, Zhengxing Uribe, Carlos F Lau, Joseph Zhang, Chengcheng Colpo, Nadine Lin, Kuo-Shyan Bénard, François Published in Molecular pharmaceutics (05.11.2018)

“...We designed and evaluated a novel albumin-binder-conjugated 177Lu-PSMA-617 derivative, 177Lu-HTK01169, with an extended blood retention time to maximize the...”

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Journal Article

The Effects of Monosodium Glutamate on PSMA Radiotracer Uptake in Men with Recurrent Prostate Cancer: A Prospective, Randomized, Double-Blind, Placebo-Controlled Intraindividual Im...

by Harsini, Sara Saprunoff, Heather Alden, Tina Mohammadi, Behnoud Wilson, Don Bénard, François Published in The Journal of nuclear medicine (1978) (01.01.2021)

“...The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer. However, PSMA-targeted radioligand...”

Journal Article

A Prospective Study on 18F-DCFPyL PSMA PET/CT Imaging in Biochemical Recurrence of Prostate Cancer

by Rousseau, Etienne Wilson, Don Lacroix-Poisson, Frédéric Krauze, Andra Chi, Kim Gleave, Martin McKenzie, Michael Tyldesley, Scott Goldenberg, S. Larry Bénard, François Published in Journal of Nuclear Medicine (01.11.2019)

“...18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), a prostate-specific membrane antigen–targeting...”

Journal Article

Trimeric radiofluorinated sulfonamide derivatives to achieve in vivo selectivity for carbonic anhydrase IX-targeted PET imaging

by Lau, Joseph Liu, Zhibo Lin, Kuo-Shyan Pan, Jinhe Zhang, Zhengxing Vullo, Daniela Supuran, Claudiu T Perrin, David M Bénard, François Published in The Journal of nuclear medicine (1978) (01.09.2015)

“...Carbonic anhydrase IX (CA-IX), a transmembrane enzyme, mediates cell survival under hypoxic conditions and is overexpressed in solid malignancies. In this...”

Journal Article

One-Step 18F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging

by Kuo, Hsiou-Ting Lepage, Mathieu L Lin, Kuo-Shyan Pan, Jinhe Zhang, Zhengxing Liu, Zhibo Pryyma, Alla Zhang, Chengcheng Merkens, Helen Roxin, Aron Perrin, David M Bénard, François Published in Journal of Nuclear Medicine (01.08.2019)

“...After the identification of the high-affinity glutamate-ureido scaffold, the design of several potent 18F- and 68Ga-labeled tracers has allowed spectacular...”

Journal Article

Interim PET-directed therapy in limited stage Hodgkin lymphoma initially treated with ABVD

by Villa, Diego Sehn, Laurie H Aquino-Parsons, Christina Tonseth, Petter Scott, David W Gerrie, Alina S Wilson, Donald Bénard, François Gascoyne, Randy D Slack, Graham W Farinha, Pedro Morris, James Pickles, Tom Connors, Joseph M Savage, Kerry J Published in Haematologica (Roma) (12.07.2018)

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Journal Article

Evaluation of 64Cu-Labeled Bifunctional Chelate–Bombesin Conjugates

by Ait-Mohand, Samia Fournier, Patrick Dumulon-Perreault, Véronique Kiefer, Garry E Jurek, Paul Ferreira, Cara L Bénard, François Guérin, Brigitte Published in Bioconjugate chemistry (17.08.2011)

“...Several bifunctional chelates (BFCs) were investigated as carriers of 64Cu for PET imaging. The most widely used chelator for 64Cu labeling of BFCs is DOTA...”

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Journal Article

Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [18F]AmBF3-TATE

by Lau, Joseph Pan, Jinhe Rousseau, Etienne Uribe, Carlos F Seelam, Sudhakara Reddy Sutherland, Brent W Perrin, David M Lin, Kuo-Shyan Bénard, François Published in EJNMMI research (19.03.2020)

“...Introduction [18F]AmBF3-TATE is a somatostatin agonist that selectively binds to somatostatin receptor subtype 2 (SSTR2). For clinical translation,...”

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Journal Article

Machine Learning in Nuclear Medicine: Part 2-Neural Networks and Clinical Aspects

by Zukotynski, Katherine Gaudet, Vincent Uribe, Carlos F Mathotaarachchi, Sulantha Smith, Kenneth C Rosa-Neto, Pedro Bénard, François Black, Sandra E Published in The Journal of nuclear medicine (1978) (01.01.2021)

“...This article is the second part in our machine learning series. Part 1 provided a general overview of machine learning in nuclear medicine. Part 2 focuses on...”

Journal Article

18F-Labeled Cyclized α-Melanocyte-Stimulating Hormone Derivatives for Imaging Human Melanoma Xenograft with Positron Emission Tomography

by Zhang, Chengcheng Zhang, Zhengxing Merkens, Helen Zeisler, Jutta Colpo, Nadine Hundal-Jabal, Navjit Perrin, David M Lin, Kuo-Shyan Bénard, François Published in Scientific reports (19.09.2019)

“...Abstract Since metastatic melanoma is deadly, early diagnosis thereof is crucial for managing the disease. We recently developed α-melanocyte-stimulating...”

Journal Article

Targeting the Neuropeptide Y1 Receptor for Cancer Imaging by Positron Emission Tomography Using Novel Truncated Peptides

by Zhang, Chengcheng Pan, Jinhe Lin, Kuo-Shyan Dude, Iulia Lau, Joseph Zeisler, Jutta Merkens, Helen Jenni, Silvia Guérin, Brigitte Bénard, François Published in Molecular pharmaceutics (07.11.2016)

“...The neuropeptide Y1 receptor (Y1R) is overexpressed in many human cancers, particularly breast cancer. Due to stability issues, limited success has been...”

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Journal Article

Toward 18F‐Labeled Theranostics: A Single Agent that Can Be Labeled with 18F, 64Cu, or 177Lu

by Lepage, Mathieu L Kuo, Hsiou‐Ting Roxin, Áron Huh, Sungjoon Zhang, Zhengxing Kandasamy, Rajaguru Merkens, Helen Kumlin, Joel O Limoges, Alan Zeisler, Stefan K Lin, Kuo‐Shyan Bénard, François Perrin, David M Published in Chembiochem : a European journal of chemical biology (01.04.2020)

“...We report a single‐molecule radiotracer that can be labeled independently with 18F‐fluoride or radiometals (64Cu, 177Lu) in a single step. A prostate‐specific...”

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Journal Article

PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with 68Ga-Labeled Benzenesulfonamides

by Lau, Joseph Zhang, Zhengxing Jenni, Silvia Kuo, Hsiou-Ting Liu, Zhibo Vullo, Daniela Supuran, Claudiu T Lin, Kuo-Shyan Bénard, François Published in Molecular pharmaceutics (07.03.2016)

“...Carbonic anhydrase IX (CA-IX) is a HIF-1-inducible enzyme that is overexpressed in many cancer subtypes to promote survival and invasion in hypoxic niches...”

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Journal Article

Synthesis and evaluation of an 18F-labeled boramino acid analog of aminosuberic acid for PET imaging of the antiporter system xC

by Čolović, Milena Rousseau, Etienne Zhang, Zhengxing Lau, Joseph Zhang, Chengcheng Kuo, Hsiou-Ting Yang, Hua Schaffer, Paul François Bénard Lin, Kuo-Shyan Published in Bioorganic & medicinal chemistry letters (01.12.2018)

“...[Display omitted] •18F-ASu-BF3 is a boramino acid analog of aminosuberic acid.•18F-ASu-BF3 is a substrate of the system xC− amino acid transporter.•Rapid renal...”

Journal Article

Monosodium Glutamate Reduces 68Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model

by Rousseau, Etienne Lau, Joseph Kuo, Hsiou-Ting Zhang, Zhengxing Merkens, Helen Hundal-Jabal, Navjit Colpo, Nadine Lin, Kuo-Shyan Bénard, François Published in Journal of Nuclear Medicine (01.12.2018)

“...We evaluated the ability of monosodium glutamate (MSG) to reduce salivary and kidney uptake of a prostate-specific membrane antigen (PSMA) radioligand without...”

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