Search Results - "BMC cancer"

Journal Article

Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial

by Brodowicz, Thomas Liegl-Atzwager, Bernadette Tresch, Emmanuelle Taieb, Sophie Kramar, Andrew Gruenwald, Viktor Vanseymortier, Marie Clisant, Stéphanie Blay, Jean-Yves Le Cesne, Axel Penel, Nicolas Published in BMC cancer (14.03.2015)

“...Angiogenesis, among other signaling pathways, plays a key-role in sarcoma biology. Regorafenib (RE) has recently been shown to be effective in imatinib and...”

Journal Article

Auto-immune thyroid dysfunction induced by tyrosine kinase inhibitors in a patient with recurrent chordoma

by Eroukhmanoff, Juliette Castinetti, Frederic Penel, Nicolas Salas, Sebastien Published in BMC cancer (24.08.2016)

“...While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for...”

Journal Article

PRognostic factor of Early Death In phase II Trials or the end of 'sufficient life expectancy' as an inclusion criterion? (PREDIT model)

by Grellety, Thomas Cousin, Sophie Letinier, Louis Bosco-Lévy, Pauline Hoppe, Stéphanie Joly, Damien Penel, Nicolas Mathoulin-Pelissier, Simone Italiano, Antoine Published in BMC cancer (04.10.2016)

“...Optimizing patient selection is a necessary step to design better clinical trials. 'Life expectancy' is a frequent inclusion criterion in phase II trial...”

Journal Article

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

by Genin, Marie Clement, Francois Fattaccioli, Antoine Raes, Martine Michiels, Carine Published in BMC cancer (08.08.2015)

“...Tumor associated macrophages (TAMs) are present in high density in solid tumors. TAMs share many characteristics with alternatively activated macrophages, also...”

Journal Article

Hypoxic enhancement of exosome release by breast cancer cells

by King, Hamish W Michael, Michael Z Gleadle, Jonathan M Published in BMC cancer (24.09.2012)

“...Exosomes are nanovesicles secreted by tumour cells which have roles in paracrine signalling during tumour progression, including tumour-stromal interactions,...”

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Journal Article

Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression

by Lu, Kai-hua Li, Wei Liu, Xiang-hua Sun, Ming Zhang, Mei-ling Wu, Wei-qin Xie, Wei-ping Hou, Ya-yi Published in BMC cancer (07.10.2013)

“...Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation of their biological...”

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Journal Article

Colorectal cancer liver metastases—A population‐based study on incidence, management and survival

by Engstrand, Jennie Nilsson, Henrik Strömberg, Cecilia Jonas, Eduard Freedman, Jacob Published in BMC cancer (15.01.2018)

“...Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25-30% of those affected. Previous data suggest a...”

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Journal Article

The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer

by Liu, Xiang-hua Liu, Zhi-li Sun, Ming Liu, Jing Wang, Zhao-xia De, Wei Published in BMC cancer (08.10.2013)

“...The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding...”

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Journal Article

Long‐term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: Final update of the pivotal ERIVANCE BCC study

by Sekulic, Aleksandar Migden, Michael R Basset-Seguin, Nicole Garbe, Claus Gesierich, Anja Lao, Christopher D Miller, Chris Mortier, Laurent Murrell, Dedee F Hamid, Omid Quevedo, Jorge F Hou, Jeannie McKenna, Edward Dimier, Natalie Williams, Sarah Schadendorf, Dirk Hauschild, Axel Published in BMC cancer (16.05.2017)

“...In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration-approved Hedgehog pathway inhibitor, showed objective...”

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Journal Article

Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer

by Sun, Ming Jin, Fei-yan Xia, Rui Kong, Rong Li, Jin-hai Xu, Tong-peng Liu, Yan-wen Zhang, Er-bao Liu, Xiang-hua De, Wei Published in BMC cancer (06.05.2014)

“...Gastric cancer is the second leading cause of cancer death and remains a major clinical challenge due to poor prognosis and limited treatment options. Long...”

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Journal Article

PROGgeneV2: enhancements on the existing database

by Goswami, Chirayu Pankaj Nakshatri, Harikrishna Published in BMC cancer (17.12.2014)

“...We recently published PROGgene, a tool that can be used to study prognostic implications of genes in various cancers. The first version of the tool had several...”

Journal Article

Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis

by Yu, Jing Liu, Lian Zhang, Yue Wei, Jia Yang, Fan Published in BMC cancer (14.04.2017)

“...Surgical resection remains the primary treatment for gastrointestinal (GI) malignancy including early-stage cancer. Omega-3 polyunsaturated fatty acids (n-3...”

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Journal Article

Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

by Gorges, Tobias M Tinhofer, Ingeborg Drosch, Michael Röse, Lars Zollner, Thomas M Krahn, Thomas von Ahsen, Oliver Published in BMC cancer (16.05.2012)

“...Circulating tumour cells (CTCs) have shown prognostic relevance in metastatic breast, prostate, colon and pancreatic cancer. For further development of CTCs as...”

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Journal Article

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

by Medrek, Catharina Pontén, Fredrik Jirström, Karin Leandersson, Karin Published in BMC cancer (23.07.2012)

“...Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and...”

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Journal Article

Prognostic significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in advanced gastric cancer patients treated with FOLFOX chemotherapy

by Lee, Suee Oh, Sung Yong Kim, Sung Hyun Lee, Ji Hyun Kim, Min Chan Kim, Ki Han Kim, Hyo-Jin Published in BMC cancer (22.07.2013)

“...Several inflammatory response materials could be used for prediction of prognosis of cancer patients. The neutrophil lymphocyte ratio (NLR), and the platelet...”

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Journal Article

Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated...

by Smith, J Joshua Chow, Oliver S Gollub, Marc J Nash, Garrett M Temple, Larissa K Weiser, Martin R Guillem, José G Paty, Philip B Avila, Karin Garcia-Aguilar, Julio Published in BMC cancer (23.10.2015)

“...Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and...”

Journal Article

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

by Mrozik, Krzysztof Marek Blaschuk, Orest William Cheong, Chee Man Zannettino, Andrew Christopher William Vandyke, Kate Published in BMC cancer (01.10.2018)

“...In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition,...”

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Journal Article

Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

by Webb, Anderson H Gao, Bradley T Goldsmith, Zachary K Irvine, Andrew S Saleh, Nabil Lee, Ryan P Lendermon, Justin B Bheemreddy, Rajini Zhang, Qiuhua Brennan, Rachel C Johnson, Dianna Steinle, Jena J Wilson, Matthew W Morales-Tirado, Vanessa M Published in BMC cancer (20.06.2017)

“...Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed...”

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Journal Article

Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor spe...

by Nielsen, Torsten Wallden, Brett Schaper, Carl Ferree, Sean Liu, Shuzhen Gao, Dongxia Barry, Garrett Dowidar, Naeem Maysuria, Malini Storhoff, James Published in BMC cancer (13.03.2014)

“...NanoString's Prosigna™ Breast Cancer Prognostic Gene Signature Assay is based on the PAM50 gene expression signature. The test outputs a risk of recurrence...”

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Journal Article

Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients

by Endzeliņš, Edgars Berger, Andreas Melne, Vita Bajo-Santos, Cristina Soboļevska, Kristīne Ābols, Artūrs Rodriguez, Marta Šantare, Daiga Rudņickiha, Anastasija Lietuvietis, Vilnis Llorente, Alicia Linē, Aija Published in BMC cancer (09.11.2017)

“...Circulating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer. They can exist in...”

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