Search Results - "Bioorganic & medicinal chemistry letters"

Journal Article

Bioorganic and medicinal chemistry letters [electronic resource]

by ScienceDirect (Online service)
Published in Bioorganic & medicinal chemistry letters

Journal Article

Bioorganic and medicinal chemistry letters [electronic resource]

by Elsevier Science (Firm)
Published in Bioorganic & medicinal chemistry letters

Journal

Bioorganic & medicinal chemistry letters: a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistr...

Holdings Uni Bonn

Journal Article

New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines

by Bézière, Nicolas Goossens, Laurence Pommery, Jean Vezin, Hervé Touati, Nadia Hénichart, Jean-Pierre Pommery, Nicole Published in Bioorganic & medicinal chemistry letters (2008)

“...A study of the action mechanism of new NO-donating profens on prostatic cancer cell lines is reported. The design of profen hybrids containing a NO donor...”

Journal Article

Bioorganic and medicinal chemistry letters

Published in Bioorganic & medicinal chemistry letters

Journal Article

Bioorganic and medicinal chemistry letters

Published in Bioorganic & medicinal chemistry letters

Journal Article

Bioorganic and medicinal chemistry letters

Published in Bioorganic & medicinal chemistry letters

Journal Article

The use of spirocyclic scaffolds in drug discovery

by Zheng, Yajun Tice, Colin M Singh, Suresh B Published in Bioorganic & medicinal chemistry letters (15.08.2014)

“...Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review,...”

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Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases

by Del Prete, Sonia Vullo, Daniela Fisher, Gillian M Andrews, Katherine T Poulsen, Sally-Ann Capasso, Clemente Supuran, Claudiu T Published in Bioorganic & medicinal chemistry letters (15.09.2014)

“...The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the most lethal type of human malaria, contains a single gene annotated as...”

Journal Article

Biased agonism: An emerging paradigm in GPCR drug discovery

by Rankovic, Zoran Brust, Tarsis F Bohn, Laura M Published in Bioorganic & medicinal chemistry letters (15.01.2016)

“...[Display omitted] G protein coupled receptors have historically been one of the most druggable classes of cellular proteins. The members of this large receptor...”

Journal Article

Carbonic anhydrase inhibitors

by Supuran, Claudiu T Published in Bioorganic & medicinal chemistry letters (15.06.2010)

“...CA II protein fold, Zn(II) ion, and its coordination by three histidine residues. Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all...”

Journal Article

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

by Sánchez-Martínez, Concepción Gelbert, Lawrence M Lallena, María José de Dios, Alfonso Published in Bioorganic & medicinal chemistry letters (01.09.2015)

“...[Display omitted] Sustained proliferative capacity is a hallmark of cancer. In mammalian cells proliferation is controlled by the cell cycle, where...”

Journal Article

Antibiotic adjuvants – A strategy to unlock bacterial resistance to antibiotics

by González-Bello, Concepción Published in Bioorganic & medicinal chemistry letters (15.09.2017)

“...[Display omitted] Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to...”

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Journal Article

Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

by Martino, Emanuela Casamassima, Giuseppe Castiglione, Sonia Cellupica, Edoardo Pantalone, Serena Papagni, Francesca Rui, Marta Siciliano, Angela Marika Collina, Simona Published in Bioorganic & medicinal chemistry letters (15.09.2018)

“...[Display omitted] •Natural sources provide the 60% of currently-used anticancer agents.•Microtubule-targeting agents have a high therapeutic potential but side...”

Journal Article

Antibody–drug conjugates—A new wave of cancer drugs

by Bouchard, Hervé Viskov, Christian Garcia-Echeverria, Carlos Published in Bioorganic & medicinal chemistry letters (01.12.2014)

“...[Display omitted] Antibody–drug conjugates (ADCs) consist of cytotoxic drugs covalently linked to monoclonal antibodies directed to antigens differentially...”

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Journal Article

Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges

by Edmondson, Scott D Yang, Bin Fallan, Charlene Published in Bioorganic & medicinal chemistry letters (01.07.2019)

“...[Display omitted] Proteolysis targeting chimeras (PROTACs) are heterobifunctional compounds with molecular weights and other properties that lie outside the...”

Journal Article

Recent encounters with atropisomerism in drug discovery

by Glunz, Peter W Published in Bioorganic & medicinal chemistry letters (15.01.2018)

“...[Display omitted] Atropisomerism is stereochemistry arising from restricted bond rotation that creates a chiral axis. Atropisomers are subject to...”

Journal Article

Small-molecule quadruplex-targeted drug discovery

by Ohnmacht, Stephan A Neidle, Stephen Published in Bioorganic & medicinal chemistry letters (15.06.2014)

“...Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the human genome they have...”

Journal Article

The SARS-CoV-2 main protease as drug target

by Ullrich, Sven Nitsche, Christoph Published in Bioorganic & medicinal chemistry letters (01.09.2020)

“...[Display omitted] The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening global health. The virus...”

Journal Article

Design, synthesis and in vitro anti-mycobacterial evaluation of gatifloxacin-1H-1,2,3-triazole-isatin hybrids

by Xu, Zhi Zhang, Shu Song, Xufeng Qiang, Min Lv, Zaosheng Published in Bioorganic & medicinal chemistry letters (15.08.2017)

“...A set of novel gatifloxacin-1H-1,2,3-triazole-isatin hybrids 6a-l was designed, synthesized and evaluated for their in vitro anti-mycobacterial activities...”

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