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7by Zheng, Yajun Tice, Colin M Singh, Suresh B Published in Bioorganic & medicinal chemistry letters (15.08.2014)“...Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review,...”
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8by Del Prete, Sonia Vullo, Daniela Fisher, Gillian M Andrews, Katherine T Poulsen, Sally-Ann Capasso, Clemente Supuran, Claudiu T Published in Bioorganic & medicinal chemistry letters (15.09.2014)“...The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the most lethal type of human malaria, contains a single gene annotated as...”
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9by Rankovic, Zoran Brust, Tarsis F Bohn, Laura M Published in Bioorganic & medicinal chemistry letters (15.01.2016)“...[Display omitted] G protein coupled receptors have historically been one of the most druggable classes of cellular proteins. The members of this large receptor...”
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10by Supuran, Claudiu T Published in Bioorganic & medicinal chemistry letters (15.06.2010)“...CA II protein fold, Zn(II) ion, and its coordination by three histidine residues. Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all...”
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11by Sánchez-Martínez, Concepción Gelbert, Lawrence M Lallena, María José de Dios, Alfonso Published in Bioorganic & medicinal chemistry letters (01.09.2015)“...[Display omitted] Sustained proliferative capacity is a hallmark of cancer. In mammalian cells proliferation is controlled by the cell cycle, where...”
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12by González-Bello, Concepción Published in Bioorganic & medicinal chemistry letters (15.09.2017)“...[Display omitted] Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to...”
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13by Bouchard, Hervé Viskov, Christian Garcia-Echeverria, Carlos Published in Bioorganic & medicinal chemistry letters (01.12.2014)“...[Display omitted] Antibody–drug conjugates (ADCs) consist of cytotoxic drugs covalently linked to monoclonal antibodies directed to antigens differentially...”
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14by Edmondson, Scott D Yang, Bin Fallan, Charlene Published in Bioorganic & medicinal chemistry letters (01.07.2019)“...[Display omitted] Proteolysis targeting chimeras (PROTACs) are heterobifunctional compounds with molecular weights and other properties that lie outside the...”
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15by Glunz, Peter W Published in Bioorganic & medicinal chemistry letters (15.01.2018)“...[Display omitted] Atropisomerism is stereochemistry arising from restricted bond rotation that creates a chiral axis. Atropisomers are subject to...”
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16by Ohnmacht, Stephan A Neidle, Stephen Published in Bioorganic & medicinal chemistry letters (15.06.2014)“...Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the human genome they have...”
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17by Xu, Zhi Zhang, Shu Song, Xufeng Qiang, Min Lv, Zaosheng Published in Bioorganic & medicinal chemistry letters (15.08.2017)“...A set of novel gatifloxacin-1H-1,2,3-triazole-isatin hybrids 6a-l was designed, synthesized and evaluated for their in vitro anti-mycobacterial activities...”
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18by Martino, Emanuela Della Volpe, Serena Terribile, Elisa Benetti, Emanuele Sakaj, Mirena Centamore, Adriana Sala, Andrea Collina, Simona Published in Bioorganic & medicinal chemistry letters (15.02.2017)“...[Display omitted] 20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA...”
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19by Biamonte, Marco A Wanner, Jutta Le Roch, Karine G Published in Bioorganic & medicinal chemistry letters (15.05.2013)“...This digest covers some of the most relevant progress in malaria drug discovery published between 2010 and 2012. There is an urgent need to develop new...”
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20by Yang, Ka Song, Yanling Xie, Haibo Wu, Hao Wu, Yi-Ting Leisten, Eric D Tang, Weiping Published in Bioorganic & medicinal chemistry letters (01.08.2018)“...[Display omitted] •First small molecule degraders for zinc-dependent HDACs.•HDAC6 selective degraders.•Selectively remove HDAC6 by the...”