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  • Your search results: "Bioorganic & medicinal chemistry letters"
Showing 1 - 20 results of 43,595 for search '"Bioorganic & medicinal chemistry letters"', query time: 1.88s Narrow search
  • 1
    Cover Image Journal
    Bioorganic & medicinal chemistry letters: a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistr...
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  • 2
    Cover Image Journal Article
    Bioorganic and medicinal chemistry letters [electronic resource]
    by Elsevier Science (Firm)
    Published in Bioorganic & medicinal chemistry letters
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  • 3
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    Bioorganic and medicinal chemistry letters [electronic resource]
    by ScienceDirect (Online service)
    Published in Bioorganic & medicinal chemistry letters
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  • 4
    Cover Image Journal Article
    Bioorganic and medicinal chemistry letters
    Published in Bioorganic & medicinal chemistry letters
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  • 5
    Cover Image Journal Article
    Bioorganic and medicinal chemistry letters
    Published in Bioorganic & medicinal chemistry letters
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  • 6
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    Bioorganic and medicinal chemistry letters
    Published in Bioorganic & medicinal chemistry letters
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  • 7
    Cover Image Journal Article
    The use of spirocyclic scaffolds in drug discovery
    by Zheng, Yajun   Tice, Colin M   Singh, Suresh B Published in Bioorganic & medicinal chemistry letters (15.08.2014)
    “...Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review,...”
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  • 8
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    Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases
    by Del Prete, Sonia   Vullo, Daniela   Fisher, Gillian M   Andrews, Katherine T   Poulsen, Sally-Ann   Capasso, Clemente   Supuran, Claudiu T Published in Bioorganic & medicinal chemistry letters (15.09.2014)
    “...The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the most lethal type of human malaria, contains a single gene annotated as...”
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  • 9
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    Biased agonism: An emerging paradigm in GPCR drug discovery
    by Rankovic, Zoran   Brust, Tarsis F   Bohn, Laura M Published in Bioorganic & medicinal chemistry letters (15.01.2016)
    “...[Display omitted] G protein coupled receptors have historically been one of the most druggable classes of cellular proteins. The members of this large receptor...”
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  • 10
    Cover Image Journal Article
    Carbonic anhydrase inhibitors
    by Supuran, Claudiu T Published in Bioorganic & medicinal chemistry letters (15.06.2010)
    “...CA II protein fold, Zn(II) ion, and its coordination by three histidine residues. Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all...”
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  • 11
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    Cyclin dependent kinase (CDK) inhibitors as anticancer drugs
    by Sánchez-Martínez, Concepción   Gelbert, Lawrence M   Lallena, María José   de Dios, Alfonso Published in Bioorganic & medicinal chemistry letters (01.09.2015)
    “...[Display omitted] Sustained proliferative capacity is a hallmark of cancer. In mammalian cells proliferation is controlled by the cell cycle, where...”
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  • 12
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    Antibiotic adjuvants – A strategy to unlock bacterial resistance to antibiotics
    by González-Bello, Concepción Published in Bioorganic & medicinal chemistry letters (15.09.2017)
    “...[Display omitted] Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to...”
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  • 13
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    Antibody–drug conjugates—A new wave of cancer drugs
    by Bouchard, Hervé   Viskov, Christian   Garcia-Echeverria, Carlos Published in Bioorganic & medicinal chemistry letters (01.12.2014)
    “...[Display omitted] Antibody–drug conjugates (ADCs) consist of cytotoxic drugs covalently linked to monoclonal antibodies directed to antigens differentially...”
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  • 14
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    Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges
    by Edmondson, Scott D   Yang, Bin   Fallan, Charlene Published in Bioorganic & medicinal chemistry letters (01.07.2019)
    “...[Display omitted] Proteolysis targeting chimeras (PROTACs) are heterobifunctional compounds with molecular weights and other properties that lie outside the...”
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  • 15
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    Recent encounters with atropisomerism in drug discovery
    by Glunz, Peter W Published in Bioorganic & medicinal chemistry letters (15.01.2018)
    “...[Display omitted] Atropisomerism is stereochemistry arising from restricted bond rotation that creates a chiral axis. Atropisomers are subject to...”
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  • 16
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    Small-molecule quadruplex-targeted drug discovery
    by Ohnmacht, Stephan A   Neidle, Stephen Published in Bioorganic & medicinal chemistry letters (15.06.2014)
    “...Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the human genome they have...”
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  • 17
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    Design, synthesis and in vitro anti-mycobacterial evaluation of gatifloxacin-1H-1,2,3-triazole-isatin hybrids
    by Xu, Zhi   Zhang, Shu   Song, Xufeng   Qiang, Min   Lv, Zaosheng Published in Bioorganic & medicinal chemistry letters (15.08.2017)
    “...A set of novel gatifloxacin-1H-1,2,3-triazole-isatin hybrids 6a-l was designed, synthesized and evaluated for their in vitro anti-mycobacterial activities...”
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  • 18
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    The long story of camptothecin: From traditional medicine to drugs
    by Martino, Emanuela   Della Volpe, Serena   Terribile, Elisa   Benetti, Emanuele   Sakaj, Mirena   Centamore, Adriana   Sala, Andrea   Collina, Simona Published in Bioorganic & medicinal chemistry letters (15.02.2017)
    “...[Display omitted] 20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA...”
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  • 19
    Cover Image Journal Article
    Recent advances in malaria drug discovery
    by Biamonte, Marco A   Wanner, Jutta   Le Roch, Karine G Published in Bioorganic & medicinal chemistry letters (15.05.2013)
    “...This digest covers some of the most relevant progress in malaria drug discovery published between 2010 and 2012. There is an urgent need to develop new...”
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  • 20
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    Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
    by Yang, Ka   Song, Yanling   Xie, Haibo   Wu, Hao   Wu, Yi-Ting   Leisten, Eric D   Tang, Weiping Published in Bioorganic & medicinal chemistry letters (01.08.2018)
    “...[Display omitted] •First small molecule degraders for zinc-dependent HDACs.•HDAC6 selective degraders.•Selectively remove HDAC6 by the...”
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