Search Results - "Cheng, Albert"

Journal Article

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

by Yang, Hui Wang, Haoyi Shivalila, Chikdu S Cheng, Albert W Shi, Linyu Jaenisch, Rudolf Published in Cell (Cambridge) (12.09.2013)

“...The type II bacterial CRISPR/Cas system is a novel genome-engineering technology with the ease of multiplexed gene targeting. Here, we created reporter and...”

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Journal Article

CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells

by Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang Published in Cell research (2017)

“...Chimeric antigen receptor （CAR） T cell therapy is a promising approach to treat cancer, such as B-cell ma- lignancy [1]. However, the current standard...”

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Journal Article

Solving Energy-Aware Real-Time Tasks Scheduling Problem with Shuffled Frog Leaping Algorithm on Heterogeneous Platforms

by Zhang, Weizhe Bai, Enci He, Hui Cheng, Albert M K Published in Sensors (Basel, Switzerland) (11.06.2015)

“...Reducing energy consumption is becoming very important in order to keep battery life and lower overall operational costs for heterogeneous real-time...”

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Journal Article

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

by Rudenko, Andrii Dawlaty, Meelad M Seo, Jinsoo Cheng, Albert W Meng, Jia Le, Thuc Faull, Kym F Jaenisch, Rudolf Tsai, Li-Huei Published in Neuron (Cambridge, Mass.) (18.09.2013)

“...The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and...”

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Journal Article

Do Personnel Policies Matter for Organizational Mission Coherence? A Public School Test

by Cheng, Albert Published in Review of public personnel administration (01.12.2016)

“...Public administration theory suggests that building mission coherence within an organization is important for its effectiveness. Personnel policies may...”

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Journal Article

Experimentally Estimated Impacts of School Vouchers on Educational Attainments of Moderately and Severely Disadvantaged Students

by Cheng, Albert Peterson, Paul E Published in Sociology of education (01.04.2021)

“...For decades, social theorists have posited—and descriptive accounts have shown—that students isolated by both social class and ethnicity suffer extreme...”

Journal Article

Parental Empowerment, Involvement, and Satisfaction: A Comparison of Choosers of Charter, Catholic, Christian, and District-Run Public Schools

by Hamlin, Daniel Cheng, Albert Published in Educational administration quarterly (01.10.2020)

“...Purpose: This study investigates parental empowerment, involvement, and satisfaction in charter, Catholic, Christian, and district-run public schools. The...”

Journal Article

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

by Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch Published in Cell research (2013)

“...Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We...”

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Journal Article

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

by Buganim, Yosef Faddah, Dina A Cheng, Albert W Itskovich, Elena Markoulaki, Styliani Ganz, Kibibi Klemm, Sandy L van Oudenaarden, Alexander Jaenisch, Rudolf Published in Cell (Cambridge) (14.09.2012)

“...During cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during...”

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Journal Article

A Longitudinal Analysis of Volunteerism Activities for Individuals Educated in Public and Private Schools

by Cheng, Albert Sikkink, David Published in Youth & society (01.10.2020)

“...Previous studies offer evidence that U.S. public and private high schools differentially influence volunteerism in adolescence. However, these studies are...”

Journal Article

Single-Cell Analysis Reveals that Expression of Nanog Is Biallelic and Equally Variable as that of Other Pluripotency Factors in Mouse ESCs

by Faddah, Dina A Wang, Haoyi Cheng, Albert Wu Katz, Yarden Buganim, Yosef Jaenisch, Rudolf Published in Cell stem cell (03.07.2013)

“...The homeodomain transcription factor Nanog is a central part of the core pluripotency transcriptional network and plays a critical role in embryonic stem cell...”

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Journal Article

Experimental Estimates of Impacts of Cost-Earnings Information on Adult Aspirations for Children's Postsecondary Education

by Cheng, Albert Peterson, Paul E Published in The Journal of higher education (Columbus) (04.05.2019)

“...Economic information may close aspiration disparities for postsecondary education across socioeconomic, ethnic, and partisan divides. In 2017, we estimated...”

Journal Article

Data Access Based on a Guide Map of the Underwater Wireless Sensor Network

by Wei, Zhengxian Song, Min Yin, Guisheng Song, Houbing Wang, Hongbin Ma, Xuefei Cheng, Albert M K Published in Sensors (Basel, Switzerland) (17.10.2017)

“...Underwater wireless sensor networks (UWSNs) represent an area of increasing research interest, as data storage, discovery, and query of UWSNs are always...”

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Journal Article

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

by Dawlaty, Meelad M Breiling, Achim Le, Thuc Raddatz, Günter Barrasa, M. Inmaculada Cheng, Albert W Gao, Qing Powell, Benjamin E Li, Zhe Xu, Mingjiang Faull, Kym F Lyko, Frank Jaenisch, Rudolf Published in Developmental cell (11.02.2013)

“...Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or...”

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Journal Article

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

by Dawlaty, Meelad M Breiling, Achim Le, Thuc Barrasa, M. Inmaculada Raddatz, Günter Gao, Qing Powell, Benjamin E Cheng, Albert W Faull, Kym F Lyko, Frank Jaenisch, Rudolf Published in Developmental cell (14.04.2014)

“...Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and are dynamically expressed during development. Whereas loss of...”

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Journal Article

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

by Dawlaty, Meelad M Ganz, Kibibi Powell, Benjamin E Hu, Yueh-Chiang Markoulaki, Styliani Cheng, Albert W Gao, Qing Kim, Jongpil Choi, Sang-Woon Page, David C Jaenisch, Rudolf Published in Cell stem cell (05.08.2011)

“...The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1...”

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Journal Article

Personality as a Predictor of Unit Nonresponse in an Internet Panel

by Cheng, Albert Zamarro, Gema Orriens, Bart Published in Sociological methods & research (01.08.2020)

“...Unit nonresponse in panel data sets is often a source of bias. Why certain individuals attrite from longitudinal studies and how to minimize this phenomenon...”

Journal Article

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

by Soldner, Frank Laganière, Josée Cheng, Albert W Hockemeyer, Dirk Gao, Qing Alagappan, Raaji Khurana, Vikram Golbe, Lawrence I Myers, Richard H Lindquist, Susan Zhang, Lei Guschin, Dmitry Fong, Lauren K Vu, B. Joseph Meng, Xiangdong Urnov, Fyodor D Rebar, Edward J Gregory, Philip D Zhang, H. Steve Jaenisch, Rudolf Published in Cell (Cambridge) (22.07.2011)

“...Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising...”

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Journal Article

Casilio： a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling

by Albert W Cheng Nathaniel Jillette Phoebe Lee Dylan Plaskon Yasuhiro Fuj iwara Wenbo Wang Aziz Taghbalout Haoyi Wang Published in Cell research (2016)

“...The CRISPR-Cas9 system has recently been widely adopted in genome editing due to its simplicity [1-3]. Nuclease-deficient mutant dCas9 protein can be fused to...”

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Journal Article

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

by Li, Yun Wang, Haoyi Muffat, Julien Cheng, Albert W Orlando, David A Lovén, Jakob Kwok, Show-ming Feldman, Danielle A Bateup, Helen S Gao, Qing Hockemeyer, Dirk Mitalipova, Maisam Lewis, Caroline A Vander Heiden, Matthew G Sur, Mriganka Young, Richard A Jaenisch, Rudolf Published in Cell stem cell (03.10.2013)

“...Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an...”

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