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  • Your search results: "Clinical cancer research"
Showing 1 - 20 results of 29,274 for search '"Clinical cancer research"', query time: 1.34s Narrow search
  • 1
    Cover Image eJournal
    Clinical cancer research
    related American Association for Cancer Research
    Volume available online?
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  • 2
    Cover Image Journal
    Clinical cancer research: an official journal of the American Association for Cancer Research
    related American Association for Cancer Research ¬[Herausgebendes Organ]
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    Holdings Uni Bonn
  • 3
    Cover Image Journal Article
    Journal of experimental and clinical cancer research [electronic resource] : CR
    by National Institutes of Health (U.S.). PubMed Central
    Published in Journal of experimental & clinical cancer research
    available in Bonn?
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  • 4
    Cover Image Journal Article
    Clinical cancer research [electronic resource]
    by HighWire PressAmerican Association for Cancer Research
    Published in Clinical cancer research
    available in Bonn?
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  • 5
    Cover Image Journal Article
    Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1
    by Champiat, Stéphane   Dercle, Laurent   Ammari, Samy   Massard, Christophe   Hollebecque, Antoine   Postel-Vinay, Sophie   Chaput, Nathalie   Eggermont, Alexander   Marabelle, Aurélien   Soria, Jean-Charles   Ferté, Charles Published in Clinical cancer research (15.04.2017)
    “...While immune checkpoint inhibitors are disrupting the management of patients with cancer, anecdotal occurrences of rapid progression (i.e., hyperprogressive...”
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  • 6
    Cover Image Journal Article
    EGFR mutations and ALK rearrangements are associated with low response rates to PD-1 pathway blockade in non-small cell lung cancer: a retrospective analysis
    by Gainor, Justin F   Shaw, Alice T   Sequist, Lecia V   Fu, Xiujun   Azzoli, Christopher G   Piotrowska, Zofia   Huynh, Tiffany G   Zhao, Ling   Fulton, Linnea   Schultz, Katherine R   Howe, Emily   Farago, Anna F   Sullivan, Ryan J   Stone, James R   Digumarthy, Subba   Moran, Teresa   Hata, Aaron N   Yagi, Yukako   Yeap, Beow Y   Engelman, Jeffrey A   Mino-Kenudson, Mari Published in Clinical cancer research (15.09.2016)
    “...PD-1 inhibitors are established agents in the management of non-small cell lung cancer (NSCLC); however, only a subset of patients derives clinical benefit. To...”
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  • 7
    Cover Image Journal Article
    Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti-PD-1 Therapy
    by Taube, Janis M   Klein, Alison   Brahmer, Julie R   Xu, Haiying   Pan, Xiaoyu   Kim, Jung H   Chen, Lieping   Pardoll, Drew M   Topalian, Suzanne L   Anders, Robert A Published in Clinical cancer research (01.10.2014)
    “...Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide...”
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  • 8
    Cover Image Journal Article
    Hyperprogressors after immunotherapy: Analysis of genomic alterations associated with accelerated growth rate
    by Kato, Shumei   Goodman, Aaron   Walavalkar, Vighnesh   Barkauskas, Donald A   Sharabi, Andrew   Kurzrock, Razelle Published in Clinical cancer research (01.08.2017)
    “...Checkpoint inhibitors demonstrate salutary anticancer effects, including long-term remissions. PD-L1 expression/amplification, high mutational burden, and...”
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  • 9
    Cover Image Journal Article
    Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
    by Ren, Jiangtao   Liu, Xiaojun   Fang, Chongyun   Jiang, Shuguang   June, Carl H   Zhao, Yangbing Published in Clinical cancer research (01.05.2017)
    “...Using gene-disrupted allogeneic T cells as universal effector cells provides an alternative and potentially improves current chimeric antigen receptor (CAR)...”
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  • 10
    Cover Image Journal Article
    PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression
    by Jiao, Shiping   Xia, Weiya   Yamaguchi, Hirohito   Wei, Yongkun   Chen, Mei-Kuang   Hsu, Jung-Mao   Hsu, Jennifer L   Yu, Wen-Hsuan   Du, Yi   Lee, Heng-Huan   Li, Chia-Wei   Chou, Chao-Kai   Lim, Seung-Oe   Chang, Shih-Shin   Litton, Jennifer   Arun, Banu   Hortobagyi, Gabriel N   Hung, Mien-Chie Published in Clinical cancer research (15.07.2017)
    “...To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates...”
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  • 11
    Cover Image Journal Article
    Nivolumab in Resected and Unresectable Metastatic Melanoma: Characteristics of Immune-Related Adverse Events and Association with Outcomes
    by Freeman-Keller, Morganna   Kim, Youngchul   Cronin, Heather   Richards, Allison   Gibney, Geoffrey   Weber, Jeffrey S Published in Clinical cancer research (15.02.2016)
    “...Retrospective analysis of irAEs in melanoma patients treated with nivolumab. Data were pooled from 148 patients (33 resected, 115 unresectable) treated with...”
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  • 12
    Cover Image Journal Article
    Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers
    by YU, Helena A   ARCILA, Maria E   REKHTMAN, Natasha   SIMA, Camelia S   ZAKOWSKI, Maureen F   PAO, William   KRIS, Mark G   MILLER, Vincent A   LADANYI, Marc   RIELY, Gregory J Published in Clinical cancer research (2013)
    “...All patients with EGF receptor (EGFR)-mutant lung cancers eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). Smaller series have...”
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  • 13
    Cover Image Journal Article
    Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity
    by Ballard, Peter   Yates, James W T   Yang, Zhenfan   Kim, Dong-Wan   Yang, James Chih-Hsin   Cantarini, Mireille   Pickup, Kathryn   Jordan, Angela   Hickey, Mike   Grist, Matthew   Box, Matthew   Johnström, Peter   Varnäs, Katarina   Malmquist, Jonas   Thress, Kenneth S   Jänne, Pasi A   Cross, Darren Published in Clinical cancer research (15.10.2016)
    “...Approximately one-third of patients with non-small cell lung cancer (NSCLC) harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations...”
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  • 14
    Cover Image Journal Article
    Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma
    by Dong, Zhong-Yi   Zhong, Wen-Zhao   Zhang, Xu-Chao   Su, Jian   Xie, Zhi   Liu, Si-Yang   Tu, Hai-Yan   Chen, Hua-Jun   Sun, Yue-Li   Zhou, Qing   Yang, Jin-Ji   Yang, Xue-Ning   Lin, Jia-Xin   Yan, Hong-Hong   Zhai, Hao-Ran   Yan, Li-Xu   Liao, Ri-Qiang   Wu, Si-Pei   Wu, Yi-Long Published in Clinical cancer research (15.06.2017)
    “...Although clinical studies have shown promise for targeting programmed cell death protein-1 (PD-1) and ligand (PD-L1) signaling in non-small cell lung cancer...”
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  • 15
    Cover Image Journal Article
    Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
    by Burstein, Matthew D   Tsimelzon, Anna   Poage, Graham M   Covington, Kyle R   Contreras, Alejandro   Fuqua, Suzanne A W   Savage, Michelle I   Osborne, C Kent   Hilsenbeck, Susan G   Chang, Jenny C   Mills, Gordon B   Lau, Ching C   Brown, Powel H Published in Clinical cancer research (01.04.2015)
    “...Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and...”
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  • 16
    Cover Image Journal Article
    Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab
    by Weide, Benjamin   Martens, Alexander   Hassel, Jessica C   Berking, Carola   Postow, Michael A   Bisschop, Kees   Simeone, Ester   Mangana, Johanna   Schilling, Bastian   Di Giacomo, Anna Maria   Brenner, Nicole   Kaehler, Katharina   Heinzerling, Lucie   Gutzmer, Ralf   Bender, Armin   Gebhardt, Christoffer   Romano, Emanuela   Meier, Friedegund   Martus, Peter   Maio, Michele   Blank, Christian   Schadendorf, Dirk   Dummer, Reinhard   Ascierto, Paolo A   Hospers, Geke   Garbe, Claus   Wolchok, Jedd D Published in Clinical cancer research (15.11.2016)
    “...Purpose: Biomarkers for outcome after immune-checkpoint blockade are strongly needed as these may influence individual treatment selection or sequence. We...”
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  • 17
    Cover Image Journal Article
    Microsatellite Instability as a Biomarker for PD-1 Blockade
    by Dudley, Jonathan C   Lin, Ming-Tseh   Le, Dung T   Eshleman, James R Published in Clinical cancer research (15.02.2016)
    “...Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of...”
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  • 18
    Cover Image Journal Article
    Circular RNA ciRS-7-A promising prognostic biomarker and a potential therapeutic target in colorectal cancer
    by Weng, Wenhao   Wei, Qing   Toden, Shusuke   Yoshida, Kazuhiro   Nagasaka, Takeshi   Fujiwara, Toshiyoshi   Cai, Sanjun   Qin, Huanlong   Ma, Yanlei   Goel, Ajay Published in Clinical cancer research (15.07.2017)
    “...Colorectal cancer is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As...”
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  • 19
    Cover Image Journal Article
    FDA Approval Summary: Pembrolizumab for the Treatment of Microsatellite Instability-High Solid Tumors
    by Marcus, Leigh   Lemery, Steven J   Keegan, Patricia   Pazdur, Richard Published in Clinical cancer research (01.07.2019)
    “...The FDA approved pembrolizumab on May 23, 2017, for the treatment of adult and pediatric patients with unresectable or metastatic, microsatellite...”
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  • 20
    Cover Image Journal Article
    Phase I study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
    by Patnaik, Amita   Kang, S Peter   Rasco, Drew   Papadopoulos, Kyriakos P   Elassaiss-Schaap, Jeroen   Beeram, Muralidhar   Drengler, Ronald   Chen, Cong   Smith, Lon   Espino, Guillermo   Gergich, Kevin   Delgado, Liliana   Daud, Adil   Lindia, Jill A   Li, Xiaoyun Nicole   Pierce, Robert H   Yearley, Jennifer H   Wu, Dianna   Laterza, Omar   Lehnert, Manfred   Iannone, Robert   Tolcher, Anthony W Published in Clinical cancer research (01.10.2015)
    “...This phase I study evaluated the safety, maximum tolerated dose, antitumor activity, and pharmacokinetics and pharmacodynamics of pembrolizumab in patients...”
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