Search Results - "DES ROSIERS, Christine"

Journal Article

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

by Gélinas, Roselle Mailleux, Florence Dontaine, Justine Bultot, Laurent Demeulder, Bénédicte Ginion, Audrey Daskalopoulos, Evangelos P Esfahani, Hrag Dubois-Deruy, Emilie Lauzier, Benjamin Gauthier, Chantal Olson, Aaron K Bouchard, Bertrand Des Rosiers, Christine Viollet, Benoit Sakamoto, Kei Balligand, Jean-Luc Vanoverschelde, Jean-Louis Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in Nature communications (25.01.2018)

“...AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte...”

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Journal Article

Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond

by Ruiz, Matthieu Labarthe, François Fortier, Annik Bouchard, Bertrand Thompson Legault, Julie Bolduc, Virginie Rigal, Odile Chen, Jane Ducharme, Anique Crawford, Peter A Tardif, Jean-Claude Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.10.2017)

“...Heart failure (HF) is associated with metabolic perturbations, particularly of fatty acids (FAs), which remain to be better understood in humans. This study...”

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Journal Article

Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation

by PICARD, Martin JUNG, Boris MATECKI, Stefan JABER, Samir DES ROSIERS, Christine KARPATI, George FERRI, Lorenzo BURELLE, Yan TURNBULL, Douglass M TAIVASSALO, Tanja PETROF, Basil J FENG LIANG AZUELOS, Ilan HUSSAIN, Sabah GOLDBERG, Peter CODIN, Richard DANIALOU, Gawiyou CHATURVEDI, Rakesh RYGIEL, Karolina Published in American journal of respiratory and critical care medicine (2012)

“...Mechanical ventilation (MV) is associated with adverse effects on the diaphragm, but the cellular basis for this phenomenon, referred to as ventilator-induced...”

Journal Article

The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults

by Lamantia, Valérie Bissonnette, Simon Provost, Viviane Devaux, Marie Cyr, Yannick Daneault, Caroline Rosiers, Christine Des Faraj, May Published in The Journal of nutrition (01.01.2019)

“...ABSTRACT Background δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs)...”

Journal Article

Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling

by Schmeisser, Sebastian Li, Shaolin Bouchard, Bertrand Ruiz, Matthieu Des Rosiers, Christine Roy, Richard Published in Cell reports (Cambridge) (24.12.2019)

“...A growing body of evidence suggests that changes in fat metabolism may have a significant effect on lifespan. Accumulation of lipid deposits in non-adipose...”

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Journal Article

Differential effects of octanoate and heptanoate on myocardial metabolism during extracorporeal membrane oxygenation in an infant swine model

by Kajimoto, Masaki Ledee, Dolena R Olson, Aaron K Isern, Nancy G Des Rosiers, Christine Portman, Michael A Published in American journal of physiology. Heart and circulatory physiology (01.10.2015)

“...Nutritional energy support during extracorporeal membrane oxygenation (ECMO) should promote successful myocardial adaptation and eventual weaning from the ECMO...”

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Journal Article

Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice

by Bolduc, Virginie Drouin, Annick Gillis, Marc-Antoine Duquette, Natacha Thorin-Trescases, Nathalie Frayne-Robillard, Isabelle Des Rosiers, Christine Tardif, Jean-Claude Thorin, Eric Published in American Journal of Physiology - Heart and Circulatory Physiology (01.11.2011)

“...The cardiac cycle imposes a mechanical stress that dilates elastic carotid arteries, while shear stress largely contributes to the endothelium-dependent...”

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Journal Article

Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake

by Renguet, Edith Ginion, Audrey Gélinas, Roselle Bultot, Laurent Auquier, Julien Robillard Frayne, Isabelle Daneault, Caroline Vanoverschelde, Jean-Louis Des Rosiers, Christine Hue, Louis Horman, Sandrine Beauloye, Christophe Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (01.08.2017)

“...High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose...”

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Journal Article

Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids

by Khairallah, Ramzi J Kim, Junhwan O'Shea, Karen M O'Connell, Kelly A Brown, Bethany H Galvao, Tatiana Daneault, Caroline Des Rosiers, Christine Polster, Brian M Hoppel, Charles L Stanley, William C
edited by Calbet, Jose A. L
Published in PloS one (2012-00-00)

“...Mitochondria can depolarize and trigger cell death through the opening of the mitochondrial permeability transition pore (MPTP). We recently showed that an...”

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Journal Article

MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction

by Ruiz, Matthieu Coderre, Lise Lachance, Dominic Houde, Valérie Martel, Cécile Thompson Legault, Julie Gillis, Marc-Antoine Bouchard, Bertrand Daneault, Caroline Carpentier, André C Gaestel, Matthias Allen, Bruce G Des Rosiers, Christine Published in Diabetes (New York, N.Y.) (01.02.2016)

“...Heart disease remains a major complication of diabetes, and the identification of new therapeutic targets is essential. This study investigates the role of the...”

Journal Article

Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats

by Ménard, Sébastien L Croteau, Etienne Sarrhini, Otman Gélinas, Roselle Brassard, Pascal Ouellet, René Bentourkia, M'hamed van Lier, Johannes E Des Rosiers, Christine Lecomte, Roger Carpentier, André C Published in American Journal of Physiology - Endocrinology and Metabolism (01.05.2010)

“...The purpose of this study was to determine in vivo myocardial energy metabolism and function in a nutritional model of type 2 diabetes. Wistar rats rendered...”

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Journal Article

Acute Regulation of Cardiac Metabolism by the Hexosamine Biosynthesis Pathway and Protein O-GlcNAcylation

by Laczy, Boglárka Fülöp, Norbert Onay-Besikci, Arzu Des Rosiers, Christine Chatham, John C
edited by Stadler, Krisztian
Published in PloS one (11.04.2011)

“...The hexosamine biosynthesis pathway (HBP) flux and protein O-linked N-acetyl-glucosamine (O-GlcNAc) levels have been implicated in mediating the adverse...”

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Journal Article

mTORC1 is required for expression of LRPPRC and cytochrome- c oxidase but not HIF-1α in Leigh syndrome French Canadian type patient fibroblasts

by Mukaneza, Yvette Cohen, Aaron Rivard, Marie-Ève Tardif, Jessica Deschênes, Sonia Ruiz, Matthieu Laprise, Catherine Des Rosiers, Christine Coderre, Lise Published in American Journal of Physiology: Cell Physiology (01.07.2019)

“...Leigh syndrome French Canadian type (LSFC) is a mitochondrial disease caused by mutations in the leucine-rich pentatricopeptide repeat-containing (LRPPRC) gene...”

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Journal Article

The role of oxidative stress in postprandial endothelial dysfunction

by Lacroix, Sébastien Rosiers, Christine Des Tardif, Jean-Claude Nigam, Anil Published in Nutrition research reviews (01.12.2012)

“...Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future...”

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Journal Article

Ivabradine and metoprolol differentially affect cardiac glucose metabolism despite similar heart rate reduction in a mouse model of dyslipidemia

by Vaillant, Fanny Lauzier, Benjamin Ruiz, Matthieu Shi, Yanfen Lachance, Dominic Rivard, Marie-Eve Bolduc, Virginie Thorin, Eric Tardif, Jean-Claude Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.10.2016)

“...While heart rate reduction (HRR) is a target for the management of patients with heart disease, contradictory results were reported using ivabradine, which...”

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Journal Article

Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil

by Ascah, Alexis Khairallah, Maya Daussin, Frédéric Bourcier-Lucas, Céline Godin, Richard Allen, Bruce G Petrof, Basil J Des Rosiers, Christine Burelle, Yan Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2011)

“...Susceptibility of cardiomyocytes to stress-induced damage has been implicated in the development of cardiomyopathy in Duchenne muscular dystrophy, a disease...”

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Journal Article

Mouse strain differences in metabolic fluxes and function of ex vivo working hearts

by Vaillant, Fanny Lauzier, Benjamin Poirier, Isabelle Gélinas, Roselle Rivard, Marie-Eve Robillard Frayne, Isabelle Thorin, Eric Des Rosiers, Christine Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2014)

“...In mice, genetic background is known to influence various parameters, including cardiac function. Its impact on cardiac energy substrate metabolism-a factor...”

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Journal Article

Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients

by Burelle, Yan Bemeur, Chantal Rivard, Marie-Eve Thompson Legault, Julie Boucher, Gabrielle Morin, Charles Coderre, Lise Des Rosiers, Christine
edited by Moran, Maria
Published in PloS one (2015-00-00)

“...Mutations in LRPPRC are responsible for the French Canadian variant of Leigh Syndrome (LSFC), a severe disorder characterized biochemically by a...”

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Journal Article

Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model

by Ledee, Dolena R Kajimoto, Masaki O'Kelly Priddy, Colleen M Olson, Aaron K Isern, Nancy Robillard-Frayne, Isabelle Des Rosiers, Christine Portman, Michael A Published in American journal of physiology. Heart and circulatory physiology (01.07.2015)

“...Extracorporeal membrane oxygenation (ECMO) provides mechanical circulatory support for infants and children with postoperative cardiopulmonary failure...”

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Journal Article

Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status

by Tremblay-Gravel, Maxime Fortier, Annik Baron, Cantin David, Chloé Mehanna, Pamela Ducharme, Anique Hussin, Julie Hu, Qinghua Tardif, Jean-Claude Des Rosiers, Christine Dupuis, Jocelyn Ruiz, Matthieu Published in Metabolites (26.03.2021)

“...Defects in fatty acid (FA) utilization have been well described in group 1 pulmonary hypertension (PH) and in heart failure (HF), yet poorly studied in group 2...”

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