Search Results - "DES ROSIERS, Christine"

Journal Article

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

by Gélinas, Roselle Mailleux, Florence Dontaine, Justine Bultot, Laurent Demeulder, Bénédicte Ginion, Audrey Daskalopoulos, Evangelos P Esfahani, Hrag Dubois-Deruy, Emilie Lauzier, Benjamin Gauthier, Chantal Olson, Aaron K Bouchard, Bertrand Des Rosiers, Christine Viollet, Benoit Sakamoto, Kei Balligand, Jean-Luc Vanoverschelde, Jean-Louis Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in Nature communications (25.01.2018)

“...AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte...”

Journal Article

Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond

by Ruiz, Matthieu Labarthe, François Fortier, Annik Bouchard, Bertrand Thompson Legault, Julie Bolduc, Virginie Rigal, Odile Chen, Jane Ducharme, Anique Crawford, Peter A Tardif, Jean-Claude Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.10.2017)

“...Heart failure (HF) is associated with metabolic perturbations, particularly of fatty acids (FAs), which remain to be better understood in humans. This study...”

Fulltext

Journal Article

Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation

by PICARD, Martin JUNG, Boris MATECKI, Stefan JABER, Samir DES ROSIERS, Christine KARPATI, George FERRI, Lorenzo BURELLE, Yan TURNBULL, Douglass M TAIVASSALO, Tanja PETROF, Basil J FENG LIANG AZUELOS, Ilan HUSSAIN, Sabah GOLDBERG, Peter CODIN, Richard DANIALOU, Gawiyou CHATURVEDI, Rakesh RYGIEL, Karolina Published in American journal of respiratory and critical care medicine (2012)

“...Mechanical ventilation (MV) is associated with adverse effects on the diaphragm, but the cellular basis for this phenomenon, referred to as ventilator-induced...”

Journal Article

The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults

by Lamantia, Valérie Bissonnette, Simon Provost, Viviane Devaux, Marie Cyr, Yannick Daneault, Caroline Rosiers, Christine Des Faraj, May Published in The Journal of nutrition (01.01.2019)

“...ABSTRACT Background δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs)...”

Journal Article

Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling

by Schmeisser, Sebastian Li, Shaolin Bouchard, Bertrand Ruiz, Matthieu Des Rosiers, Christine Roy, Richard Published in Cell reports (Cambridge) (24.12.2019)

“...A growing body of evidence suggests that changes in fat metabolism may have a significant effect on lifespan. Accumulation of lipid deposits in non-adipose...”

Fulltext

Journal Article

Differential effects of octanoate and heptanoate on myocardial metabolism during extracorporeal membrane oxygenation in an infant swine model

by Kajimoto, Masaki Ledee, Dolena R Olson, Aaron K Isern, Nancy G Des Rosiers, Christine Portman, Michael A Published in American journal of physiology. Heart and circulatory physiology (01.10.2015)

“...Nutritional energy support during extracorporeal membrane oxygenation (ECMO) should promote successful myocardial adaptation and eventual weaning from the ECMO...”

Fulltext

Journal Article

Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice

by Virginie Bolduc Annick Drouin Marc-Antoine Gillis Natacha Duquette Nathalie Thorin-Trescases Isabelle Frayne-Robillard Christine Des Rosiers Jean-Claude Tardif Eric Thorin Published in American Journal of Physiology - Heart and Circulatory Physiology (01.11.2011)

“...The cardiac cycle imposes a mechanical stress that dilates elastic carotid arteries, while shear stress largely contributes to the endothelium-dependent...”

Fulltext

Journal Article

Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake

by Renguet, Edith Ginion, Audrey Gélinas, Roselle Bultot, Laurent Auquier, Julien Robillard Frayne, Isabelle Daneault, Caroline Vanoverschelde, Jean-Louis Des Rosiers, Christine Hue, Louis Horman, Sandrine Beauloye, Christophe Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (01.08.2017)

“...High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose...”

Fulltext

Journal Article

The role of oxidative stress in postprandial endothelial dysfunction

by Lacroix, Sébastien Rosiers, Christine Des Tardif, Jean-Claude Nigam, Anil Published in Nutrition research reviews (01.12.2012)

“...Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future...”

Fulltext

Journal Article

MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction

by Ruiz, Matthieu Coderre, Lise Lachance, Dominic Houde, Valérie Martel, Cécile Thompson Legault, Julie Gillis, Marc-Antoine Bouchard, Bertrand Daneault, Caroline Carpentier, André C Gaestel, Matthias Allen, Bruce G Des Rosiers, Christine Published in Diabetes (New York, N.Y.) (01.02.2016)

“...Heart disease remains a major complication of diabetes, and the identification of new therapeutic targets is essential. This study investigates the role of the...”

Journal Article

Ivabradine and metoprolol differentially affect cardiac glucose metabolism despite similar heart rate reduction in a mouse model of dyslipidemia

by Vaillant, Fanny Lauzier, Benjamin Ruiz, Matthieu Shi, Yanfen Lachance, Dominic Rivard, Marie-Eve Bolduc, Virginie Thorin, Eric Tardif, Jean-Claude Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.10.2016)

“...While heart rate reduction (HRR) is a target for the management of patients with heart disease, contradictory results were reported using ivabradine, which...”

Fulltext

Journal Article

Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil

by Alexis Ascah Maya Khairallah Frédéric Daussin Céline Bourcier-Lucas Richard Godin Bruce G. Allen Basil J. Petrof Christine Des Rosiers Yan Burelle Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2011)

“...Susceptibility of cardiomyocytes to stress-induced damage has been implicated in the development of cardiomyopathy in Duchenne muscular dystrophy, a disease...”

Fulltext

Journal Article

Mouse strain differences in metabolic fluxes and function of ex vivo working hearts

by Fanny Vaillant Benjamin Lauzier Isabelle Poirier Roselle Gélinas Marie-Eve Rivard Isabelle Robillard Frayne Eric Thorin Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2014)

“...In mice, genetic background is known to influence various parameters, including cardiac function. Its impact on cardiac energy substrate metabolism-a factor...”

Fulltext

Journal Article

Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model

by Ledee, Dolena R Kajimoto, Masaki O'Kelly Priddy, Colleen M Olson, Aaron K Isern, Nancy Robillard-Frayne, Isabelle Des Rosiers, Christine Portman, Michael A Published in American journal of physiology. Heart and circulatory physiology (01.07.2015)

“...Extracorporeal membrane oxygenation (ECMO) provides mechanical circulatory support for infants and children with postoperative cardiopulmonary failure...”

Fulltext

Journal Article

Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival

by Tatiana F. Galvao Ramzi J. Khairallah Erinne R. Dabkowski Bethany H. Brown Peter A. Hecker Kelly A. O'Connell Karen M. O'Shea Hani N. Sabbah Sharad Rastogi Caroline Daneault Christine Des Rosiers William C. Stanley Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2013)

“...Mitochondrial dysfunction in heart failure includes greater susceptibility to mitochondrial permeability transition (MPT), which may worsen cardiac function...”

Fulltext

Journal Article

Myocardial oxidative metabolism and protein synthesis during mechanical circulatory support by extracorporeal membrane oxygenation

by Colleen M. O′Kelly Priddy Masaki Kajimoto Dolena R. Ledee Bertrand Bouchard Nancy Isern Aaron K. Olson Christine Des Rosiers Michael A. Portman Published in American Journal of Physiology - Heart and Circulatory Physiology (01.02.2013)

“...Extracorporeal membrane oxygenation (ECMO) provides essential mechanical circulatory support necessary for survival in infants and children with acute cardiac...”

Fulltext

Journal Article

Triiodothyronine increases myocardial function and pyruvate entry into the citric acid cycle after reperfusion in a model of infant cardiopulmonary bypass

by Aaron K. Olson Bertrand Bouchard Xue-Han Ning Nancy Isern Christine Des Rosiers Michael A. Portman Published in American Journal of Physiology - Heart and Circulatory Physiology (01.03.2012)

“...Triiodothyronine (T3) supplementation improves clinical outcomes in infants after cardiac surgery using cardiopulmonary bypass by unknown mechanisms. We...”

Fulltext

Journal Article

Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts

by Benjamin Lauzier Fanny Vaillant Roselle Gélinas Bertrand Bouchard Roger Brownsey Eric Thorin Jean-Claude Tardif Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.03.2011)

“...Heart rate reduction (HRR) is an important target in the management of patients with chronic stable angina. Most available drugs for HRR, such as β-blockers,...”

Fulltext

Journal Article

Docosahexaenoic Acid Supplementation Alters Key Properties of Cardiac Mitochondria and Modestly Attenuates Development of Left Ventricular Dysfunction in Pressure Overload-Induced...

by Dabkowski, Erinne R O’Connell, Kelly A Xu, Wenhong Ribeiro Jr, Rogerio F Hecker, Peter A Shekar, Kadambari Chandra Daneault, Caroline Des Rosiers, Christine Stanley, William C Published in Cardiovascular drugs and therapy (01.12.2013)

“...Supplementation with the n3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is beneficial in heart failure patients, however the mechanisms are unclear...”

Fulltext

Journal Article

Dynamic responses of the glutathione system to acute oxidative stress in dystrophic mouse (mdx) muscles

by Roy W. R. Dudley Maya Khairallah Shawn Mohammed Larry Lands Christine Des Rosiers Basil J. Petrof Published in American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (01.09.2006)

“...The precise mechanisms underlying skeletal muscle damage in Duchenne muscular dystrophy (DMD) remain ill-defined. Functional ischemia during muscle activation,...”

Fulltext

1
2
3
4
5
6
7
8
9
10
11
Next »
[14]

Narrow search