Search Results - "Drug design, development and therapy"

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Published in Drug design, development and therapy (2007]-)

“...Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons...”

Journal Article

Metal complexes in cancer therapy - an update from drug design perspective

by Ndagi, Umar Mhlongo, Ndumiso Soliman, Mahmoud E Published in Drug design, development and therapy (2017-00-00)

“...In the past, metal-based compounds were widely used in the treatment of disease conditions, but the lack of clear distinction between the therapeutic and toxic...”

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Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

by Ahmed, Tarek A Aljaeid, Bader M Published in Drug design, development and therapy (2016-00-00)

“...Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic...”

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Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

by Herbertz, Stephan Sawyer, J Scott Stauber, Anja J Gueorguieva, Ivelina Driscoll, Kyla E Estrem, Shawn T Cleverly, Ann L Desaiah, Durisala Guba, Susan C Benhadji, Karim A Slapak, Christopher A Lahn, Michael M Published in Drug design, development and therapy (2015-00-00)

“...Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and...”

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Animal models of ischemic stroke and their application in clinical research

by Fluri, Felix Schuhmann, Michael K Kleinschnitz, Christoph Published in Drug design, development and therapy (2015-00-00)

“...This review outlines the most frequently used rodent stroke models and discusses their strengths and shortcomings. Mimicking all aspects of human stroke in one...”

Journal Article

Eteplirsen in the treatment of Duchenne muscular dystrophy

by Lim, Kenji Rowel Q Maruyama, Rika Yokota, Toshifumi Published in Drug design, development and therapy (2017-00-00)

“...Duchenne muscular dystrophy is a fatal neuromuscular disorder affecting around one in 3,500-5,000 male births that is characterized by progressive muscular...”

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Current development of biodegradable polymeric materials for biomedical applications

by Song, Richard Murphy, Maxwell Li, Chenshuang Ting, Kang Soo, Chia Zheng, Zhong Published in Drug design, development and therapy (2018-00-00)

“...In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric...”

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Modulation of neurotrophic signaling pathways by polyphenols

by Moosavi, Fatemeh Hosseini, Razieh Saso, Luciano Firuzi, Omidreza Published in Drug design, development and therapy (2016-00-00)

“...Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of...”

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Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

by Ganguly, Gargi Chakrabarti, Sasanka Chatterjee, Uttara Saso, Luciano Published in Drug design, development and therapy (2017-00-00)

“...Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity...”

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Bispecific antibodies: design, therapy, perspectives

by Sedykh, Sergey E Prinz, Victor V Buneva, Valentina N Nevinsky, Georgy A Published in Drug design, development and therapy (2018-00-00)

“...Antibodies (Abs) containing two different antigen-binding sites in one molecule are called bispecific. Bispecific Abs (BsAbs) were first described in the...”

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8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

by Prachayasittikul, Veda Prachayasittikul, Supaluk Ruchirawat, Somsak Prachayasittikul, Virapong Published in Drug design, development and therapy (2013-00-00)

“...Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases...”

Journal Article

Apatinib for molecular targeted therapy in tumor

by Zhang, Haijun Published in Drug design, development and therapy (2015-00-00)

“...As tumor angiogenesis is one of the hallmarks of cancer, the inhibition of vascular endothelial growth factor signaling has become an attractive anticancer...”

Journal Article

Molecular mechanisms of cisplatin resistance in cervical cancer

by Zhu, Haiyan Luo, Hui Zhang, Wenwen Shen, Zhaojun Hu, Xiaoli Zhu, Xueqiong Published in Drug design, development and therapy (2016-00-00)

“...Patients with advanced or recurrent cervical cancer have poor prognosis, and their 1-year survival is only 10%-20%. Chemotherapy is considered as the standard...”

Journal Article

Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy

by Hong, Yu Deng, Ning Jin, Han-Na Xuan, Zheng-Zheng Qian, Yi-Xiao Wu, Zhi-yong Xie, Wei Published in Drug design, development and therapy (01.01.2018)

Journal Article

Metformin: a review of its potential indications

by Wang, Yi-Wei He, Si-Jia Feng, Xiao Cheng, Jin Luo, Yun-Tao Tian, Ling Huang, Qian Published in Drug design, development and therapy (2017-00-00)

“...Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years, in addition to glucose lowering, several studies have presented...”

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Organelle targeting: third level of drug targeting

by Sakhrani, Niraj M Padh, Harish Published in Drug design, development and therapy (2013-00-00)

“...Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug...”

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Phase III study of pasireotide long‐acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues

by Wolin, Edward M Jarzab, Barbara Eriksson, Barbro Walter, Thomas Toumpanakis, Christos Morse, Michael A Tomassetti, Paola Weber, Matthias M Fogelman, David R Ramage, John Poon, Donald Gadbaw, Brian Li, Jiang Pasieka, Janice L Mahamat, Abakar Swahn, Fredrik Newell-Price, John Mansoor, Wasat Öberg, Kjell Published in Drug design, development and therapy (2015-00-00)

“...In a randomized, double-blind, Phase III study, we compared pasireotide long-acting release (pasireotide LAR) with octreotide long-acting repeatable...”

Journal Article

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: An update on its pharmacokinetic and pharmacodynamic properties

by Wang, Yan-Yang Yang, Yin-Xue Zhe, Hong He, Zhi-Xu Zhou, Shu-Feng Published in Drug design, development and therapy (2014-00-00)

“...Triterpenoids have been used for medicinal purposes in many Asian countries because of their anti-inflammatory, antioxidant, antiproliferative, anticancer, and...”

Journal Article

Update on taxane development: new analogs and new formulations

by Yared, Jean A Tkaczuk, Katherine H R Published in Drug design, development and therapy (2012-00-00)

“...The taxanes (paclitaxel and docetaxel) represent an important class of antineoplastic agents that interfere with microtubule function leading to altered...”

Journal Article

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

by Qing, Yi Li, Qing Ren, Tao Xia, Wei Peng, Yu Liu, Gao-Lei Luo, Hao Yang, Yu-Xin Dai, Xiao-Yan Zhou, Shu-Feng Wang, Dong Published in Drug design, development and therapy (2015-00-00)

“...Gastric cancer is a fatal malignancy with a rising incidence rate. Effective methods for early diagnosis, monitoring metastasis, and prognosis are currently...”

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