Search Results - "Fischer, Peter M"

Journal Article

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

by Yusuke Sekine Alisa Zyryanova Ana Crespillo-Casado Peter M. Fischer Heather P. Harding David Ron Published in Science (American Association for the Advancement of Science) (29.05.2015)

“...The integrated stress response (ISR) modulates messenger RNA translation to regulate the mammalian unfolded protein response (UPR), immunity, and memory...”

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Journal Article

Disentangling country-of-origin effects: the interplay of product ethnicity, national identity, and consumer ethnocentrism

by Peter M. Fischer Katharina P. Zeugner-Roth Published in Marketing letters (01.06.2017)

“...The country-of-origin (COO) of products has been shown to affect consumer choice, especially in situations where the origin has a stereotypical association...”

Journal Article

Cellular Delivery of Impermeable Effector Molecules in the Form of Conjugates with Peptides Capable of Mediating Membrane Translocation

by Fischer, Peter M Krausz, Eberhard Lane, David P Published in Bioconjugate chemistry (21.11.2001)

“...Most molecules that are not actively imported by living cells are impermeable to cell membranes, including practically all macromolecules and even many small...”

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Journal Article

Approved and Experimental Small‐Molecule Oncology Kinase Inhibitor Drugs: A Mid‐2016 Overview

by Fischer, Peter M Published in Medicinal research reviews (01.03.2017)

“...Kinase inhibitor research is a comparatively recent branch of medicinal chemistry and pharmacology and the first small‐molecule kinase inhibitor, imatinib, was...”

Journal Article

Investigation of the Flexibility of Protein Kinases Implicated in the Pathology of Alzheimer’s Disease

by Mazanetz, Michael P Laughton, Charles A Fischer, Peter M Published in Molecules (Basel, Switzerland) (30.06.2014)

“...The pathological characteristics of Alzheimer's Disease (AD) have been linked to the activity of three particular kinases--Glycogen Synthase Kinase 3β (GSK3β),...”

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eBook

Tell Abu al-Kharaz in the Jordan Valley : Volume III: The Iron Age

by Fischer, Peter M
01.01.2014

“...Tell city of Abu al-Kharaz is situated in the central Transjordanian Jordan Valley and excavated by the author from 1989 to 2012. The town flourished in the...”

Journal Article

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases

by Mazanetz, Michael P Fischer, Peter M Published in Nature reviews. Drug discovery (01.06.2007)

“...Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological lesions of Alzheimer's disease and other neurodegenerative disorders...”

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Journal Article

Cap in hand: Targeting eIF4E

by Fischer, Peter M Published in Cell cycle (Georgetown, Tex.) (15.08.2009)

“...Recognition of the mRNA cap structure by the translation initiation factor eIF4E is central to pro-tein synthesis in general and eIF4E activity is especially...”

Journal Article

Hala Sultan Tekke, Cyprus: A Late Bronze Age Trade Metropolis

by Fischer, Peter M Published in Near Eastern archaeology (01.12.2019)

“...The ancient city of Hala Sultan Tekke, which flourished in the Late Bronze Age, that is, from approximately 1650 to 1150 BCE, is situated on the southeastern...”

Journal Article

Tell Abu al-Kharaz: A Bead in the Jordan Valley

by Peter M. Fischer Published in Near Eastern archaeology (01.12.2008)

“...After two decades of excavation work at Tell Abu al'Kharaz ("Teil of the Father of Beads ") in the central Jordan Valley, the Swedish Jordan Expedition has...”

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Journal Article

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

by Zyryanova, Alisa F Weis, Félix Faille, Alexandre Alard, Akeel Abo Crespillo-Casado, Ana Sekine, Yusuke Harding, Heather P Allen, Felicity Parts, Leopold Fromont, Christophe Fischer, Peter M Warren, Alan J Ron, David Published in Science (American Association for the Advancement of Science) (30.03.2018)

“...The integrated stress response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory, and immunity. The ISR is mediated...”

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Journal Article

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

by Crespillo-Casado, Ana Chambers, Joseph E Fischer, Peter M Marciniak, Stefan J Ron, David Published in eLife (27.04.2017)

“...Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a...”

Journal Article

Climate Change and Social Unrest: A 6,000‐Year Chronicle From the Eastern Mediterranean

by Kaniewski, David Marriner, Nick Cheddadi, Rachid Fischer, Peter M Otto, Thierry Luce, Frédéric Van Campo, Elise Published in Geophysical research letters (16.04.2020)

“...The history of the Eastern Mediterranean is punctuated by major crises that have influenced many of the region's established socioeconomic models. Recent...”

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Journal Article

CDKI‐71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol

by Liu, Xiangrui Shi, Shenhua Lam, Frankie Pepper, Chris Fischer, Peter M Wang, Shudong Published in International journal of cancer (01.03.2012)

“...Cancer cells appear to depend heavily on antiapoptotic proteins for survival and so targeted inhibition of these proteins has therapeutic potential. One...”

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Journal Article

14C-Dating of the Late Bronze Age City of Hala Sultan Tekke, Cyprus: Status Report

by Wild, Eva M Fischer, Peter M Steier, Peter Bürge, Teresa
edited by Nadeau, Marie-Josée
Published in Radiocarbon (01.10.2019)

“...Hala Sultan Tekke is a large Bronze Age city located on the southeastern littoral of Cyprus. The city flourished from approximately 1650 BC to 1150 BC...”

Journal Article

Turning down tau phosphorylation

by Fischer, Peter M Published in Nature chemical biology (01.08.2008)

“...Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological...”

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Journal Article

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

by Zgair, Atheer Lee, Jong Bong Wong, Jonathan C M Taha, Dhiaa A Aram, Jehan Di Virgilio, Daisy McArthur, Joshua W Cheng, Yu-Kit Hennig, Ivo M Barrett, David A Fischer, Peter M Constantinescu, Cris S Gershkovich, Pavel Published in Scientific reports (06.11.2017)

“...Cannabidiol (CBD) and ∆ -tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans...”

Journal Article

Synthetic lethal targeting of DNA double‐strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

by Sultana, Rebeka McNeill, Daniel R Abbotts, Rachel Mohammed, Mohammed Z Zdzienicka, Malgorzata Z Qutob, Haitham Seedhouse, Claire Laughton, Charles A Fischer, Peter M Patel, Poulam M Wilson, David M Madhusudan, Srinivasan Published in International journal of cancer (15.11.2012)

“...An apurinic/apyrimidinic (AP) site is an obligatory cytotoxic intermediate in DNA Base Excision Repair (BER) that is processed by human AP endonuclease 1...”

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Journal Article

Tombs and Offering Pits at the Late Bronze Age Metropolis of Hala Sultan Tekke, Cyprus

by Peter M. Fischer Teresa Bürge Published in Bulletin of the American Schools of Oriental Research (01.05.2017)

“...Hala Sultan Tekke is a large Bronze Age city close to the famous homonymous mosque near the international airport of Larnaca on the south coast of Cyprus...”

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Book

Applications of technical devices in archaeology: the use of X-rays, microscope, electrical and electro-magnetic devices and subsurface interface radar

by Fischer, Peter M
1980 ;

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