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1
Journal Article
by Fontana, Gabriele A Hess, Daniel Reinert, Julia K Mattarocci, Stefano Falquet, Benoît Klein, Dominique Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature communications (10.06.2019)“...Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular...”
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2
Journal Article
by Mattarocci, Stefano Reinert, Julia K Bunker, Richard D Fontana, Gabriele A Shi, Tianlai Klein, Dominique Cavadini, Simone Faty, Mahamadou Shyian, Maksym Hafner, Lukas Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature structural & molecular biology (01.07.2017)“...In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chromosome ends. In mammalian cells, Rif1 is not telomeric,...”
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3
Journal Article
by Fontana, Gabriele A Reinert, Julia K Thomä, Nicolas H Rass, Ulrich Published in Microbial cell (17.05.2018)“...Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs)...”
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4
Journal Article
“...Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions...”
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5
Journal Article
“...Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions...”
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6
Journal Article
by Fontana, Gabriele A Hess, Daniel Reinert, Julia K Mattarocci, Stefano Falquet, Benoît Klein, Dominique Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature Communications (10.06.2019)“...Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular...”
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7
Journal Article
by Fontana, Gabriele A Rigamonti, Aurora Lenzken, Silvia C Filosa, Giuseppe Alvarez, Reinaldo Calogero, Raffaele Bianchi, Marco E Barabino, Silvia M L Published in Nucleic acids research (25.01.2017)“...Alternative splicing of terminal exons increases transcript and protein diversity. How physiological and pathological stimuli regulate the choice between...”
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8
Journal Article
“...DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross...”
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9
Journal Article
by Fontana, Gabriele A Hess, Daniel Reinert, Julia K Falquet, Benoît Shore, David Thomä, Nicolas H Rass, Ulrich Mattarocci, Stefano Klein, Dominique Published in Nature Communications (01.06.2019)“...International audience; Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to...”
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10
Patent
“...Disclosed is a compound having the formula a) or b); a: R=CH3; b: R=CH2CH3, and its use in the prevention and/or treatment of Alzheimer's disease...”
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11
Patent
“...Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients...”
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12
Patent
“...Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8...”
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13
Patent
“...This invention relates to a "one pot" process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the...”
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14
Patent
“...Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical...”
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15
Patent
“...The invention concerns the use of glucomoringin and of its des-thio- glucoside having the following formulae (I, II): for the preparation of a medicament for...”
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16
Patent
“...5-substituted camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and...”
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17
Patent
“...The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable...”
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18
Patent
“...The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed...”
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19
Patent
“...The invention concerns the use of glucomoringin and of its des-thio- glucoside having the following formulae (I, II): for the preparation of a medicament for...”
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20
Patent
“...The invention discloses novel secotaxane derivatives of general formula 1, having cytotoxic activity, which can be administered through the injective or oral...”
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