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  • Your search results: "Fowler, Philip"
Showing 1 - 20 results of 227 for search '"Fowler, Philip"', query time: 1.72s Narrow search
  • 1
    Cover Image Journal Article
    Nothing to Sneeze At: A Dynamic and Integrative Computational Model of an Influenza A Virion
    by Reddy, Tyler   Shorthouse, David   Parton, Daniel L   Jefferys, Elizabeth   Fowler, Philip W   Chavent, Matthieu   Baaden, Marc   Sansom, Mark S.P Published in Structure (London) (03.03.2015)
    “...The influenza virus is surrounded by an envelope composed of a lipid bilayer and integral membrane proteins. Understanding the structural dynamics of the...”
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  • 2
    Cover Image Journal Article
    Gating Topology of the Proton-Coupled Oligopeptide Symporters
    by Fowler, Philip W   Orwick-Rydmark, Marcella   Radestock, Sebastian   Solcan, Nicolae   Dijkman, Patricia M   Lyons, Joseph A   Kwok, Jane   Caffrey, Martin   Watts, Anthony   Forrest, Lucy R   Newstead, Simon Published in Structure (London) (03.02.2015)
    “...Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS...”
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  • 3
    Cover Image Journal Article
    Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes
    by Duncan, Anna L   Reddy, Tyler   Koldsø, Heidi   Hélie, Jean   Fowler, Philip W   Chavent, Matthieu   Sansom, Mark S P Published in Scientific reports (30.11.2017)
    “...Cell membranes are crowded and complex environments. To investigate the effect of protein-lipid interactions on dynamic organization in mammalian cell...”
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  • 4
    Cover Image Journal Article
    Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter
    by Samsudin, Firdaus   Parker, Joanne L   Sansom, Mark S.P   Newstead, Simon   Fowler, Philip W Published in Cell chemical biology (18.02.2016)
    “...Membrane transporters are critical modulators of drug pharmacokinetics, efficacy, and safety. One example is the proton-dependent oligopeptide transporter...”
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  • 5
    Cover Image Journal Article
    Proxy variables and nonparametric identification of causal effects
    by de Luna, Xavier   Fowler, Philip   Johansson, Per Published in Economics letters (01.01.2017)
    “...Proxy variables are often used in linear regression models with the aim of removing potential confounding bias. In this paper we formalise proxy variables...”
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  • 6
    Cover Image Journal Article
    Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport
    by Beale, John H   Parker, Joanne L   Samsudin, Firdaus   Barrett, Anne L   Senan, Anish   Bird, Louise E   Scott, David   Owens, Raymond J   Sansom, Mark S.P   Tucker, Stephen J   Meredith, David   Fowler, Philip W   Newstead, Simon Published in Structure (London) (06.10.2015)
    “...Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the...”
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  • 7
    Cover Image Journal Article
    Dissecting the Roles of Membrane Curvature, Lipid Raft Formation and Protein-Lipid Interactions in the Clustering of Ras
    by Fowler, Philip W   Sansom, Mark S.P Published in Biophysical journal (28.01.2014)
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  • 8
    Cover Image Journal Article
    Investigating the Role of Bilayer Size and Composition on Membrane Fluctuations using Large Coarse-Grained Simulations
    by Fowler, Philip W   Koldsø, Heidi   Duncan, Anna   Sansom, Mark S.P Published in Biophysical journal (27.01.2015)
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  • 9
    Cover Image Journal Article
    The Effect of Proteins and Lipids on Membrane Stiffness
    by Fowler, Philip W   Duncan, Anna   Helie, Jean   Chavent, Matthieu   Koldsø, Heidi   Sansom, Mark S.P Published in Biophysical journal (16.02.2016)
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  • 10
    Cover Image Journal Article
    GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes
    by Wilson, Daniel J
    edited by Rosenberg, Michael
    Published in Molecular biology and evolution (13.03.2020)
    “...The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino...”
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  • 11
    Cover Image Journal Article
    Nothing to Sneeze at: A Full-Scale Computational Model of the Human Influenza Virion
    by Reddy, Tyler   Shorthouse, David   Parton, Daniel   Jefferys, Elizabeth   Fowler, Philip W   Chavent, Matthieu   Baaden, Marc   Sansom, Mark S.P Published in Biophysical journal (27.01.2015)
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  • 12
    Cover Image Journal Article
    Which Free Energy Methods can Predict Transport by Proton-Dependent Oligopeptide Symporters?
    by Samsudin, M. Firdaus   Solcan, Nicolae   Newstead, Simon   Sansom, Mark S.P   Fowler, Philip W Published in Biophysical journal (27.01.2015)
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  • 13
    Cover Image Journal Article
    Alternating access mechanism in the POT family of oligopeptide transporters
    by Solcan, Nicolae   Kwok, Jane   Fowler, Philip W   Cameron, Alexander D   Drew, David   Iwata, So   Newstead, Simon Published in The EMBO journal (15.08.2012)
    “...Short chain peptides are actively transported across membranes as an efficient route for dietary protein absorption and for maintaining cellular homeostasis...”
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  • 14
    Cover Image Journal Article
    How Do Peptides and Drugs Bind to the Peptide Transporters?
    by Fowler, Philip W   Newstead, Simon   Sansom, Mark S.P Published in Biophysical journal (2011)
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  • 15
    Cover Image Journal Article
    Voltage-Gated Potassium Ion Channels are Frustrated
    by Fowler, Philip W   Sansom, Mark S.P Published in Biophysical journal (2011)
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  • 16
    Cover Image Journal Article
    Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2
    by Iwata, So   Ingram, Jean C   Cameron, Alexander D   Sansom, Mark S P   Baldwin, Stephen A   Drew, David   Xia, Xiaobing   Fowler, Philip W   Carpenter, Elisabeth P   McPherson, Michael J   Postis, Vincent L G   Newstead, Simon Published in The EMBO journal (19.01.2011)
    “...PepT1 and PepT2 are major facilitator superfamily (MFS) transporters that utilize a proton gradient to drive the uptake of di‐ and tri‐peptides in the small...”
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  • 17
    Cover Image Journal Article
    Using DEER, Modelling and Simulations to Investigate the Dynamics of PepTSo, a Major Facilitator Superfamily Transporter of Biomedical Importance
    by Fowler, Philip W   Orwick-Rydmark, Marcella   Solcan, Nicolae   Radestock, Sebastian   Dijkman, Patricia   Kwok, Jane   Samsudin, Firdaus   Watts, Anthony   Forrest, Lucy   Newstead, Simon Published in Biophysical journal (29.01.2013)
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  • 18
    Cover Image Journal Article
    Structural and Thermodynamic Characterization of the Gating Pathway in a K+ Channel
    by Bollepalli, Murali K   Fowler, Philip W   Rapedius, Markus   Shang, Lijun   Sansom, Mark S.P   Tucker, Stephen J   Baukrowitz, Thomas Published in Biophysical journal (28.01.2014)
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  • 19
    Cover Image Journal Article
    State-Dependent Network Connectivity Determines Gating in a K+ Channel
    by Bollepalli, Murali K   Fowler, Philip W   Rapedius, Markus   Shang, Lijun   Sansom, Mark S.P   Tucker, Stephen J   Baukrowitz, Thomas Published in Structure (London) (08.07.2014)
    “...X-ray crystallography has provided tremendous insight into the different structural states of membrane proteins and, in particular, of ion channels. However,...”
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  • 20
    Cover Image Journal Article
    The pore of voltage-gated potassium ion channels is strained when closed
    by Fowler, Philip W   Sansom, Mark S P Published in Nature communications (2013-00-00)
    “...Voltage-gated potassium channels form potassium-selective pores in cell membranes. They open or close in response to changes in the transmembrane potential and...”
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