Search Results - "Fowler, Philip"

Journal Article

Nothing to Sneeze At: A Dynamic and Integrative Computational Model of an Influenza A Virion

by Reddy, Tyler Shorthouse, David Parton, Daniel L Jefferys, Elizabeth Fowler, Philip W Chavent, Matthieu Baaden, Marc Sansom, Mark S.P Published in Structure (London) (03.03.2015)

“...The influenza virus is surrounded by an envelope composed of a lipid bilayer and integral membrane proteins. Understanding the structural dynamics of the...”

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Journal Article

Gating Topology of the Proton-Coupled Oligopeptide Symporters

by Fowler, Philip W Orwick-Rydmark, Marcella Radestock, Sebastian Solcan, Nicolae Dijkman, Patricia M Lyons, Joseph A Kwok, Jane Caffrey, Martin Watts, Anthony Forrest, Lucy R Newstead, Simon Published in Structure (London) (03.02.2015)

“...Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS...”

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Journal Article

Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter

by Samsudin, Firdaus Parker, Joanne L Sansom, Mark S.P Newstead, Simon Fowler, Philip W Published in Cell chemical biology (18.02.2016)

“...Membrane transporters are critical modulators of drug pharmacokinetics, efficacy, and safety. One example is the proton-dependent oligopeptide transporter...”

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Journal Article

Proxy variables and nonparametric identification of causal effects

by de Luna, Xavier Fowler, Philip Johansson, Per Published in Economics letters (01.01.2017)

“...Proxy variables are often used in linear regression models with the aim of removing potential confounding bias. In this paper we formalise proxy variables...”

Journal Article

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport

by Beale, John H Parker, Joanne L Samsudin, Firdaus Barrett, Anne L Senan, Anish Bird, Louise E Scott, David Owens, Raymond J Sansom, Mark S.P Tucker, Stephen J Meredith, David Fowler, Philip W Newstead, Simon Published in Structure (London) (06.10.2015)

“...Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the...”

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Journal Article

Dissecting the Roles of Membrane Curvature, Lipid Raft Formation and Protein-Lipid Interactions in the Clustering of Ras

by Fowler, Philip W Sansom, Mark S.P Published in Biophysical journal (28.01.2014)

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Journal Article

Investigating the Role of Bilayer Size and Composition on Membrane Fluctuations using Large Coarse-Grained Simulations

by Fowler, Philip W Koldsø, Heidi Duncan, Anna Sansom, Mark S.P Published in Biophysical journal (27.01.2015)

“...Byline: Philip W. Fowler, Heidi Koldso, Anna Duncan, Mark S.P. Sansom Author Affiliation: Biochemistry, University of Oxford, Oxford, United Kingdom Article...”

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Journal Article

The Effect of Proteins and Lipids on Membrane Stiffness

by Fowler, Philip W Duncan, Anna Helie, Jean Chavent, Matthieu Koldsø, Heidi Sansom, Mark S.P Published in Biophysical journal (16.02.2016)

“...Byline: Philip W. Fowler, Anna Duncan, Jean Helie, Matthieu Chavent, Heidi Koldso, Mark S.P. Sansom Author Affiliation: Biochemistry, University of Oxford,...”

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Publication

Validating a 14-drug microtitre plate containing bedaquiline and delamanid for large-scale research susceptibility testing of Mycobacterium tuberculosis

by Rancoita, Paola Mv Cugnata, Federica Cruz, Ana Luíza Gibertoni Borroni, Emanuele Hoosdally, Sarah J Walker, Timothy M Grazian, Clara Davies, Timothy J Peto, Timothy Ea Crook, Derrick W Fowler, Philip W Cirillo, Daniela M
08.01.2018

“...ABSTRACT UKMYC5 is a 96-well microtitre plate designed by the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) to...”

Journal Article

Alternating access mechanism in the POT family of oligopeptide transporters

by Solcan, Nicolae Kwok, Jane Fowler, Philip W Cameron, Alexander D Drew, David Iwata, So Newstead, Simon Published in The EMBO journal (15.08.2012)

“...Short chain peptides are actively transported across membranes as an efficient route for dietary protein absorption and for maintaining cellular homeostasis...”

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Journal Article

Which Free Energy Methods can Predict Transport by Proton-Dependent Oligopeptide Symporters?

by Samsudin, M. Firdaus Solcan, Nicolae Newstead, Simon Sansom, Mark S.P Fowler, Philip W Published in Biophysical journal (27.01.2015)

“...Byline: M. Firdaus Samsudin, Nicolae Solcan, Simon Newstead, Mark S.P. Sansom, Philip W. Fowler Author Affiliation: Department of Biochemistry, University of...”

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Journal Article

Nothing to Sneeze at: A Full-Scale Computational Model of the Human Influenza Virion

by Reddy, Tyler Shorthouse, David Parton, Daniel Jefferys, Elizabeth Fowler, Philip W Chavent, Matthieu Baaden, Marc Sansom, Mark S.P Published in Biophysical journal (27.01.2015)

“...Byline: Tyler Reddy, David Shorthouse, Daniel Parton, Elizabeth Jefferys, Philip W. Fowler, Matthieu Chavent, Marc Baaden, Mark S.P. Sansom Author Affiliation:...”

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Publication

Automated detection of bacterial growth on 96-well plates for high-throughput drug susceptibility testing of Mycobacterium tuberculosis

by Fowler, Philip W Gibertoni Cruz, Ana Luíza Hoosdally, Sarah J Jarrett, Lisa Borroni, Emanuele Chiacchiaretta, Matteo Rathod, Priti Walker, Timothy M Robinson, Esther Peto, Timothy E. A Maria Cirillo, Daniela Smith, E. Grace Crook, Derrick W
05.12.2017

“...Abstract M. tuberculosis grows slowly and is challenging to work with experimentally compared with many other bacteria. Although microtitre plates have the...”

Journal Article

Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

by Newstead, Simon Drew, David Cameron, Alexander D Postis, Vincent L G Xia, Xiaobing Fowler, Philip W Ingram, Jean C Carpenter, Elisabeth P Sansom, Mark S P McPherson, Michael J Baldwin, Stephen A Iwata, So Published in The EMBO journal (19.01.2011)

“...PepT1 and PepT2 are major facilitator superfamily (MFS) transporters that utilize a proton gradient to drive the uptake of di‐ and tri‐peptides in the small...”

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Journal Article

How Do Peptides and Drugs Bind to the Peptide Transporters?

by Fowler, Philip W Newstead, Simon Sansom, Mark S.P Published in Biophysical journal (2011)

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Journal Article

Voltage-Gated Potassium Ion Channels are Frustrated

by Fowler, Philip W Sansom, Mark S.P Published in Biophysical journal (2011)

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Journal Article

Using DEER, Modelling and Simulations to Investigate the Dynamics of PepTSo, a Major Facilitator Superfamily Transporter of Biomedical Importance

by Fowler, Philip W Orwick-Rydmark, Marcella Solcan, Nicolae Radestock, Sebastian Dijkman, Patricia Kwok, Jane Samsudin, Firdaus Watts, Anthony Forrest, Lucy Newstead, Simon Published in Biophysical journal (29.01.2013)

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Journal Article

Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes

by Duncan, Anna L Reddy, Tyler Koldsø, Heidi Hélie, Jean Fowler, Philip W Chavent, Matthieu Sansom, Mark S P Published in Scientific reports (30.11.2017)

“...Cell membranes are crowded and complex environments. To investigate the effect of protein-lipid interactions on dynamic organization in mammalian cell...”

Journal Article

Structural and Thermodynamic Characterization of the Gating Pathway in a K+ Channel

by Bollepalli, Murali K Fowler, Philip W Rapedius, Markus Shang, Lijun Sansom, Mark S.P Tucker, Stephen J Baukrowitz, Thomas Published in Biophysical journal (28.01.2014)

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Journal Article

The pore of voltage-gated potassium ion channels is strained when closed

by Fowler, Philip W Sansom, Mark S P Published in Nature communications (2013-00-00)

“...Voltage-gated potassium channels form potassium-selective pores in cell membranes. They open or close in response to changes in the transmembrane potential and...”

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