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1by Reddy, Tyler Shorthouse, David Parton, Daniel L Jefferys, Elizabeth Fowler, Philip W Chavent, Matthieu Baaden, Marc Sansom, Mark S.P Published in Structure (London) (03.03.2015)“...The influenza virus is surrounded by an envelope composed of a lipid bilayer and integral membrane proteins. Understanding the structural dynamics of the...”
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2by Fowler, Philip W Orwick-Rydmark, Marcella Radestock, Sebastian Solcan, Nicolae Dijkman, Patricia M Lyons, Joseph A Kwok, Jane Caffrey, Martin Watts, Anthony Forrest, Lucy R Newstead, Simon Published in Structure (London) (03.02.2015)“...Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS...”
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3by Duncan, Anna L Reddy, Tyler Koldsø, Heidi Hélie, Jean Fowler, Philip W Chavent, Matthieu Sansom, Mark S P Published in Scientific reports (30.11.2017)“...Cell membranes are crowded and complex environments. To investigate the effect of protein-lipid interactions on dynamic organization in mammalian cell...”
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4by Samsudin, Firdaus Parker, Joanne L Sansom, Mark S.P Newstead, Simon Fowler, Philip W Published in Cell chemical biology (18.02.2016)“...Membrane transporters are critical modulators of drug pharmacokinetics, efficacy, and safety. One example is the proton-dependent oligopeptide transporter...”
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5“...Proxy variables are often used in linear regression models with the aim of removing potential confounding bias. In this paper we formalise proxy variables...”
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6by Beale, John H Parker, Joanne L Samsudin, Firdaus Barrett, Anne L Senan, Anish Bird, Louise E Scott, David Owens, Raymond J Sansom, Mark S.P Tucker, Stephen J Meredith, David Fowler, Philip W Newstead, Simon Published in Structure (London) (06.10.2015)“...Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the...”
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10by Wilson, Daniel J“...The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino...”
edited by Rosenberg, Michael
Published in Molecular biology and evolution (13.03.2020)
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13by Solcan, Nicolae Kwok, Jane Fowler, Philip W Cameron, Alexander D Drew, David Iwata, So Newstead, Simon Published in The EMBO journal (15.08.2012)“...Short chain peptides are actively transported across membranes as an efficient route for dietary protein absorption and for maintaining cellular homeostasis...”
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16by Iwata, So Ingram, Jean C Cameron, Alexander D Sansom, Mark S P Baldwin, Stephen A Drew, David Xia, Xiaobing Fowler, Philip W Carpenter, Elisabeth P McPherson, Michael J Postis, Vincent L G Newstead, Simon Published in The EMBO journal (19.01.2011)“...PepT1 and PepT2 are major facilitator superfamily (MFS) transporters that utilize a proton gradient to drive the uptake of di‐ and tri‐peptides in the small...”
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19by Bollepalli, Murali K Fowler, Philip W Rapedius, Markus Shang, Lijun Sansom, Mark S.P Tucker, Stephen J Baukrowitz, Thomas Published in Structure (London) (08.07.2014)“...X-ray crystallography has provided tremendous insight into the different structural states of membrane proteins and, in particular, of ion channels. However,...”
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20“...Voltage-gated potassium channels form potassium-selective pores in cell membranes. They open or close in response to changes in the transmembrane potential and...”