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“...The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in...”
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by Lathia, Justin D Mack, Stephen C Mulkearns-Hubert, Erin E Valentim, Claudia L L Rich, Jeremy N Published in Genes & development (15.06.2015)“...Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate...”
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“...The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune...”
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“...The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in...”
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“...Macroautophagy (referred to here as autophagy) is induced by starvation to capture and degrade intracellular proteins and organelles in lysosomes, which...”
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“...Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs...”
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“...The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])-Keap1 (Kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated...”
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“...The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but as an important modulator and even a driver of tumorigenicity...”
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“...Recent deep sequencing studies have revealed thousands of circular noncoding RNAs generated from protein-coding genes. These RNAs are produced when the...”
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by Cabili, Moran N Trapnell, Cole Goff, Loyal Koziol, Magdalena Tazon-Vega, Barbara Regev, Aviv Rinn, John L Published in Genes & development (15.09.2011)“...Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse cellular processes. Determining the function of individual lincRNAs...”
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“...N(6)-methyladenosine (m(6)A) is the most prevalent and internal modification that occurs in the messenger RNAs (mRNA) of most eukaryotes, although its...”
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“...Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The...”
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“...The discovery of poly(ADP-ribose) >50 years ago opened a new field, leading the way for the discovery of the poly(ADP-ribose) polymerase (PARP) family of...”
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by Arun, Gayatri Diermeier, Sarah Akerman, Martin Chang, Kung-Chi Wilkinson, J Erby Hearn, Stephen Kim, Youngsoo MacLeod, A Robert Krainer, Adrian R Norton, Larry Brogi, Edi Egeblad, Mikala Spector, David L Published in Genes & development (01.01.2016)“...Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the...”
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by Molofsky, Anna V Krencik, Robert Krenick, Robert Ullian, Erik M Ullian, Erik Tsai, Hui-hsin Deneen, Benjamin Richardson, William D Barres, Ben A Rowitch, David H Published in Genes & development (01.05.2012)“...Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies indicate that astrocytes are morphologically and functionally...”
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