Search Results - "KLEINJUNG, FRANK"

Journal Article

Riociguat improves health-related quality of life for patients with pulmonary arterial hypertension: results from the phase 4 MOTION study

by Sood, Namita Aranda, Alvaro Platt, David LaRose, Anneliese Kleinjung, Frank O’Brien, Gerald Published in Pulmonary circulation (01.02.2019)

“...Pulmonary arterial hypertension (PAH) is characterized by progressive dyspnea and exercise limitation and is associated with reduced health-related quality of...”

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Journal Article

Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study

by Simonneau, Gérald Ghofrani, Hossein-Ardeschir Corris, Paul A Rosenkranz, Stephan Grünig, Ekkehard White, Jim McLaughlin, Vallerie V Langleben, David Meier, Christian Busse, Dennis Kleinjung, Frank Benza, Raymond L Published in Pulmonary circulation (01.12.2020)

“...The goal of treatment in patients with pulmonary arterial hypertension is to achieve a low risk status, indicating a favorable long-term outcome. The REPLACE...”

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Journal Article

Switching inhaled iloprost formulations in patients with pulmonary arterial hypertension: the VENTASWITCH Trial

by Richter, Manuel J Stollfuß, Barbara Roitenberg, Alexander Kleinjung, Frank Graeff , Valentin Berghaus, Sabine Müller, Christian Ghofrani, Hossein-Ardeschir Published in Pulmonary circulation (01.09.2018)

“...Inhaled iloprost is an effective therapy for patients with pulmonary arterial hypertension (PAH); however, some patients experience extended inhalation times...”

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Journal Article

PPINGUIN: Peptide Profiling Guided Identification of Proteins improves quantitation of iTRAQ ratios

by Bauer, Chris Kleinjung, Frank Rutishauser, Dorothea Panse, Christian Chadt, Alexandra Dreja, Tanja Al-Hasani, Hadi Reinert, Knut Schlapbach, Ralph Schuchhardt, Johannes Published in BMC bioinformatics (16.02.2012)

“...Recent development of novel technologies paved the way for quantitative proteomics. One of the most important among them is iTRAQ, employing isobaric tags for...”

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Journal Article

A DNA Spiegelmer to staphylococcal enterotoxin B

by Purschke, Werner G Radtke, Falko Kleinjung, Frank Klussmann, Sven Published in Nucleic acids research (15.06.2003)

“...Bacterial staphylococcal enterotoxin B is involved in several severe disease patterns and it was therefore used as a target for the generation of biologically...”

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Journal Article

Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset

by Bauer, Chris Kleinjung, Frank Smith, Celia J Towers, Mark W Tiss, Ali Chadt, Alexandra Dreja, Tanja Beule, Dieter Al-Hasani, Hadi Reinert, Knut Schuchhardt, Johannes Cramer, Rainer Published in BMC bioinformatics (09.05.2011)

“...Diabetes like many diseases and biological processes is not mono-causal. On the one hand multi-factorial studies with complex experimental design are required...”

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Journal Article

A meta-analysis of QTL for diabetes-related traits in rodents

by Christian Schmidt Nina P. Gonzaludo Sarah Strunk Stefan Dahm Johannes Schuchhardt Frank Kleinjung Stefan Wuschke Hans-Georg Joost Hadi Al-Hasani Published in Physiological Genomics (01.06.2008)

“...Crossbreeding studies in rodents have identified numerous quantitative trait loci (QTL) that are linked to diabetes-related component traits. To identify...”

Journal Article

In vivo Properties of an Anti-GnRH Spiegelmer: An Example of an Oligonucleotide-Based Therapeutic Substance Class

by Britta Wlotzka Susanne Leva Bernd Eschgfäller Jens Burmeister Frank Kleinjung Christine Kaduk Peter Muhn Holger Hess-Stumpp Sven Klussmann Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2002)

“...Spiegelmers are high-affinity L-enantiomeric oligonucleotide ligands that display high resistance to enzymatic degradation compared with D-oligonucleotides...”

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Journal Article

A Detailed View on Pacemaker Lead Parameters Remotely Transmitted after Magnetic Resonance

by WOLLMANN, CHRISTIAN G STEINER, ERICH KLEINJUNG, FRANK MAYR, HARALD Published in Pacing and clinical electrophysiology (01.06.2015)

“...Background The purpose of this study was to analyze potential influences of magnetic resonance (MR) on the course of automatically device‐based assessed lead...”

Journal Article

A Detailed View on Pacemaker Lead Parameters Remotely Transmitted after Magnetic Resonance: REMOTELY TRANSMITTED LEAD PARAMETERS AFTER MR

by WOLLMANN, CHRISTIAN G STEINER, ERICH KLEINJUNG, FRANK MAYR, HARALD Published in Pacing and clinical electrophysiology (01.06.2015)

Journal Article

SWITCHING TO RIOCIGUAT IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION NOT AT TREATMENT GOAL WITH PHOSPHODIESTERASE TYPE-5 INHIBITORS: SUBGROUP ANALYSIS RESULTS OF THE REPLACE STU...

by Hoeper, Marius Ghofrani, Hossein Al-Hiti, Hikmet Benza, Raymond Chang, Sung A Corris, Paul Gibbs, J. Simon Grünig, Ekkehard Jansa, Pavel Klinger, James Langleben, David McLaughlin, Vallerie Meyer, Gisela Ota-Arakaki, Jaquelina Peacock, Andrew Pulido, Tomas Rosenkranz, Stephan Vizza, Carmine Dario Noordegraaf, Anton Vonk White, R Chang, Mikyung Kleinjung, Frank Meier, Christian Paraschin, Karen Simonneau, Gerald Published in Chest (01.10.2020)

Journal Article

A probabilistic model for the carry-over of PCDD/Fs from feed to growing pigs

by Adolphs, Julian Kleinjung, Frank Numata, Jorge Mielke, Hans Abraham, Klaus Schafft, Helmut Müller-Graf, Christine Greiner, Matthias Published in Chemosphere (Oxford) (01.09.2013)

“...•A pharmacokinetic model was combined with a probabilistic model to gain a decision tool for risk management.•The German dioxin incident of winter 2010/2011...”

Journal Article

PPINGUIN: Peptide Profiling Guided Identification of Proteins improves quantitation of iTRAQ ratios

“...Recent development of novel technologies paved the way for quantitative proteomics. One of the most important among them is iTRAQ, employing isobaric tags for...”

Journal Article

PPINGUIN: Peptide Profiling Guided Identification of Proteins improves quantitation of iTRAQ ratios

“...Background Recent development of novel technologies paved the way for quantitative proteomics. One of the most important among them is iTRAQ, employing...”

Fulltext

Journal Article

PPINGUIN: Peptide Profiling Guided Identification of Proteins improves quantitation of iTRAQ ratios

by Bauer, Chris Kleinjung, Frank Rutishauser, Dorothea Panse, Christian Chadt, Alexandra Dreja, Tanja Al-Hasani, Hadi Reinert, Knut Schlapbach, Ralph Schuchhardt, Johannes
2012

“...BACKGROUND: Recent development of novel technologies paved the way for quantitative proteomics. One of the most important among them is iTRAQ, employing...”

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Journal Article

Systematic interpretation of cyclic nucleotide binding studies using KinetXBase

by Schweinsberg, Sonja Moll, Daniela Burghardt, Nicole C. G Hahnefeld, Claudia Schwede, Frank Zimmermann, Bastian Drewianka, Stephan Werner, Lars Kleinjung, Frank Genieser, Hans‐Gottfried Schuchhardt, Johannes Herberg, Friedrich W Published in Proteomics (Weinheim) (06.03.2008)

“...Functional proteomics aims to describe cellular protein networks in depth based on the quantification of molecular interactions. In order to study the...”

Journal Article

Feature-size limitations of microarray technology – a critical review

by Bier, Frank F Kleinjung, Frank Published in Fresenius' journal of analytical chemistry (01.09.2001)

“...The appeal of microarray technology is the possibility of large-scale parallel determination of a variety of variables simultaneously. Hence, microarray...”

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Journal Article

Differential binding studies applying functional protein microarrays and surface plasmon resonance

by Seitz, Harald Hutschenreiter, Silke Hultschig, Claus Zeilinger, Carsten Zimmermann, Bastian Kleinjung, Frank Schuchhardt, Johannes Eickhoff, Holger Herberg, Friedrich W Published in Proteomics (Weinheim) (19.10.2006)

“...A variety of different in vivo and in vitro technologies provide comprehensive insights in protein‐protein interaction networks. Here we demonstrate a novel...”

Journal Article

Systematic interpretation of cyclic nucleotide binding studies using KinetXBase: Human Brain Proteomics

by SCHWEINSBERG, Sonja MOLL, Daniela SCHUCHHARDT, Johannes HERBERG, Friedrich W BURGHARDT, Nicole C. G HAHNEFELD, Claudia SCHWEDE, Frank ZIMMERMANN, Bastian DREWIANKA, Stephan WERNER, Lars KLEINJUNG, Frank GENIESER, Hans-Gottfried Published in Proteomics (Weinheim) (2008)

Journal Article

Biostable aptamers with antagonistic properties to the neuropeptide nociceptin/orphanin FQ

by Faulhammer, Dirk Eschgfäller, Bernd Stark, Sandra Burgstaller, Petra Englberger, Werner Erfurth, Jeannette Kleinjung, Frank Rupp, Johanna Dan Vulcu, Sebastian Schröder, Werner Vonhoff, Stefan Nawrath, Hermann Gillen, Clemens Klussmann, Sven Published in RNA (Cambridge) (01.03.2004)

“...The neuropeptide nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor, has been shown to play a prominent role...”

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