Search Results - "Klein, Florian"

Journal Article

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

by Caskey, Marina Klein, Florian Nussenzweig, Michel C Published in Nature medicine (01.04.2019)

“...Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of HIV-1 infection. Taken daily, ART prevents and suppresses the...”

Journal Article

Antibody-mediated prevention and treatment of HIV-1 infection

by Gruell, Henning Klein, Florian Published in Retrovirology (16.11.2018)

“...Novel broadly neutralizing antibodies targeting HIV-1 hold promise for their use in the prevention and treatment of HIV-1 infection. Pre-clinical results have...”

Fulltext

Journal Article

Antibody Teamwork against Ebola Virus Disease

by Zehner, Matthias Klein, Florian Published in Immunity (Cambridge, Mass.) (18.02.2020)

“...Antibodies are key components to prevent and treat Ebola virus disease (EVD). In this issue of Immunity, Gilchuk et al. decipher the underlying mechanism of...”

Journal Article

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

by Caskey, Marina Klein, Florian Nussenzweig, Michel C Published in The New England journal of medicine (24.11.2016)

“...High serum titers of neutralizing antibodies develop in a small fraction of people who become infected with HIV-1. Isolation of such broadly neutralizing...”

Journal Article

Antibodies in HIV-1 Vaccine Development and Therapy

by Florian Klein Hugo Mouquet Pia Dosenovic Johannes F. Scheid Louise Scharf Michel C. Nussenzweig Published in Science (American Association for the Advancement of Science) (13.09.2013)

“...Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of...”

Fulltext

Journal Article

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

by Gautam, Rajeev Nishimura, Yoshiaki Pegu, Amarendra Nason, Martha C Klein, Florian Gazumyan, Anna Golijanin, Jovana Buckler-White, Alicia Sadjadpour, Reza Wang, Keyun Mankoff, Zachary Schmidt, Stephen D Lifson, Jeffrey D Mascola, John R Nussenzweig, Michel C Martin, Malcolm A Published in Nature (London) (05.05.2016)

“...Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency virus type 1 (HIV-1) infection, little progress has been made in...”

Journal Article

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

by Shingai, Masashi Nishimura, Yoshiaki Klein, Florian Mouquet, Hugo Donau, Olivia K Plishka, Ronald Buckler-White, Alicia Seaman, Michael Piatak, Jr, Michael Lifson, Jeffrey D Dimitrov, Dimiter S Nussenzweig, Michel C Martin, Malcolm A Published in Nature (London) (14.11.2013)

“...Neutralizing antibodies can confer immunity to primate lentiviruses by blocking infection in macaque models of AIDS. However, earlier studies of anti-human...”

Journal Article

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

by Caskey, Marina Klein, Florian Lorenzi, Julio C C Seaman, Michael S West, Jr, Anthony P Buckley, Noreen Kremer, Gisela Nogueira, Lilian Braunschweig, Malte Scheid, Johannes F Horwitz, Joshua A Shimeliovich, Irina Ben-Avraham, Sivan Witmer-Pack, Maggi Platten, Martin Lehmann, Clara Burke, Leah A Hawthorne, Thomas Gorelick, Robert J Walker, Bruce D Keler, Tibor Gulick, Roy M Fätkenheuer, Gerd Schlesinger, Sarah J Nussenzweig, Michel C Published in Nature (London) (25.06.2015)

“...HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was...”

Journal Article

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

by Mendoza, Pilar Gruell, Henning Nogueira, Lilian Pai, Joy A Butler, Allison L Millard, Katrina Lehmann, Clara Suárez, Isabelle Oliveira, Thiago Y Lorenzi, Julio C C Cohen, Yehuda Z Wyen, Christoph Kümmerle, Tim Karagounis, Theodora Lu, Ching-Lan Handl, Lisa Unson-O'Brien, Cecilia Patel, Roshni Ruping, Carola Schlotz, Maike Witmer-Pack, Maggi Shimeliovich, Irina Kremer, Gisela Thomas, Eleonore Seaton, Kelly E Horowitz, Jill West, Jr, Anthony P Bjorkman, Pamela J Tomaras, Georgia D Gulick, Roy M Pfeifer, Nico Fätkenheuer, Gerd Seaman, Michael S Klein, Florian Caskey, Marina Nussenzweig, Michel C Published in Nature (London) (01.09.2018)

“...Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a...”

Journal Article

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

by Barouch, Dan H Whitney, James B Moldt, Brian Klein, Florian Oliveira, Thiago Y Liu, Jinyan Stephenson, Kathryn E Chang, Hui-Wen Shekhar, Karthik Gupta, Sanjana Nkolola, Joseph P Seaman, Michael S Smith, Kaitlin M Borducchi, Erica N Cabral, Crystal Smith, Jeffrey Y Blackmore, Stephen Sanisetty, Srisowmya Perry, James R Beck, Matthew Lewis, Mark G Rinaldi, William Chakraborty, Arup K Poignard, Pascal Nussenzweig, Michel C Burton, Dennis R Published in Nature (London) (14.11.2013)

“...Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described. In humanized...”

Journal Article

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

by Gristick, Harry B von Boehmer, Lotta West, Jr, Anthony P Schamber, Michael Gazumyan, Anna Golijanin, Jovana Seaman, Michael S Fätkenheuer, Gerd Klein, Florian Nussenzweig, Michel C Bjorkman, Pamela J Published in Nature structural & molecular biology (01.10.2016)

“...HIV-1 vaccine design is informed by structural studies elucidating mechanisms by which broadly neutralizing antibodies (bNAbs) recognize and/or accommodate...”

Journal Article

Early antibody therapy can induce long-lasting immunity to SHIV

by Nishimura, Yoshiaki Gautam, Rajeev Chun, Tae-Wook Sadjadpour, Reza Foulds, Kathryn E Shingai, Masashi Klein, Florian Gazumyan, Anna Golijanin, Jovana Donaldson, Mitzi Donau, Olivia K Plishka, Ronald J Buckler-White, Alicia Seaman, Michael S Lifson, Jeffrey D Koup, Richard A Fauci, Anthony S Nussenzweig, Michel C Martin, Malcolm A Published in Nature (London) (23.03.2017)

“...Highly potent and broadly neutralizing anti-HIV-1 antibodies (bNAbs) have been used to prevent and treat lentivirus infections in humanized mice, macaques, and...”

Journal Article

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

by Scheid, Johannes F Horwitz, Joshua A Bar-On, Yotam Kreider, Edward F Lu, Ching-Lan Lorenzi, Julio C C Feldmann, Anna Braunschweig, Malte Nogueira, Lilian Oliveira, Thiago Shimeliovich, Irina Patel, Roshni Burke, Leah Cohen, Yehuda Z Hadrigan, Sonya Settler, Allison Witmer-Pack, Maggi West, Jr, Anthony P Juelg, Boris Keler, Tibor Hawthorne, Thomas Zingman, Barry Gulick, Roy M Pfeifer, Nico Learn, Gerald H Seaman, Michael S Bjorkman, Pamela J Klein, Florian Schlesinger, Sarah J Walker, Bruce D Hahn, Beatrice H Nussenzweig, Michel C Caskey, Marina Published in Nature (London) (28.07.2016)

“...Interruption of combination antiretroviral therapy in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open...”

Journal Article

The surgeon's role on chemical investigations of the composition of urinary stones

by Laube, Norbert Klein, Florian Fisang, Christian Published in Urolithiasis (20.05.2020)

“...The chemical analysis of an urolith is often interpreted as "stone's composition". However, it must be taken into consideration, that in most cases, only a...”

Journal Article

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

by KLEIN, Florian HALPER-STROMBERG, Ariel ZANG, Trinity DORNER, Marcus BILLERBECK, Eva LABITT, Rachael N GAEBLER, Christian MARCOVECCHIO, Paola M INCESU, Reha-Baris EISENREICH, Thomas R BIENIASZ, Paul D SEAMAN, Michael S HORWITZ, Joshua A BJORKMAN, Pamela J RAVETCH, Jeffrey V PLOSS, Alexander NUSSENZWEIG, Michel C GRUELL, Henning SCHEID, Johannes F BOURNAZOS, Stylianos MOUQUET, Hugo SPATZ, Linda A DISKIN, Ron ABADIR, Alexander Published in Nature (London) (2012)

“...Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range of viral isolates in vitro and protect non-human primates against...”

Journal Article

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

by Ron Diskin Johannes F. Scheid Paola M. Marcovecchio Anthony P. West Florian Klein Han Gao Priyanthi N. P. Gnanapragasam Alexander Abadir Michael S. Seaman Michel C. Nussenzweig Pamela J. Bjorkman Published in Science (American Association for the Advancement of Science) (02.12.2011)

“...Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of...”

Fulltext

Journal Article

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

by Bar-On, Yotam Gruell, Henning Schoofs, Till Pai, Joy A Nogueira, Lilian Butler, Allison L Millard, Katrina Lehmann, Clara Suárez, Isabelle Oliveira, Thiago Y Karagounis, Theodora Cohen, Yehuda Z Wyen, Christoph Scholten, Stefan Handl, Lisa Belblidia, Shiraz Dizon, Juan P Vehreschild, Jörg J Witmer-Pack, Maggi Shimeliovich, Irina Jain, Kanika Fiddike, Kerstin Seaton, Kelly E Yates, Nicole L Horowitz, Jill Gulick, Roy M Pfeifer, Nico Tomaras, Georgia D Seaman, Michael S Fätkenheuer, Gerd Caskey, Marina Klein, Florian Nussenzweig, Michel C Published in Nature medicine (01.11.2018)

“...Monotherapy of HIV-1 infection with single antiretroviral agents is ineffective because error-prone HIV-1 replication leads to the production of drug-resistant...”

Journal Article

Optimal pooling strategies under heterogeneous risk classes

by Klein, Florian Schmeiser, Hato Published in The journal of risk finance (30.06.2020)

“...Purpose The purpose of this paper is to determine optimal pooling strategies from the perspective of an insurer's shareholders underlying a default probability...”

Journal Article

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

by Johannes F. Scheid Hugo Mouquet Beatrix Ueberheide Ron Diskin Florian Klein Thiago Y. K. Oliveira John Pietzsch David Fenyo Alexander Abadir Klara Velinzon Arlene Hurley Sunnie Myung Farid Boulad Pascal Poignard Dennis R. Burton Florencia Pereyra David D. Ho Bruce D. Walker Michael S. Seaman Pamela J. Bjorkman Brian T. Chait Michel C. Nussenzweig Published in Science (American Association for the Advancement of Science) (16.09.2011)

“...Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective...”

Fulltext

Journal Article

COVID‐19 associated pulmonary aspergillosis

by Koehler, Philipp Cornely, Oliver A Böttiger, Bernd W Dusse, Fabian Eichenauer, Dennis A Fuchs, Frieder Hallek, Michael Jung, Norma Klein, Florian Persigehl, Thorsten Rybniker, Jan Kochanek, Matthias Böll, Boris Shimabukuro‐Vornhagen, Alexander Published in Mycoses (01.06.2020)

“...Summary Objectives Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive...”

Fulltext

1
2
3
4
5
6
7
8
9
10
11
Next »
[20]

Narrow search