Search Results - "Koch, Philipp"

Journal Article

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

by Ladewig, Julia Koch, Philipp Brüstle, Oliver Published in Nature reviews. Molecular cell biology (01.04.2013)

“...For decades, Waddington's concept of the 'epigenetic landscape' has served as an educative hierarchical model to illustrate the progressive restriction of cell...”

Journal Article

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

by Leibing, Thomas Géraud, Cyrill Augustin, Iris Boutros, Michael Augustin, Hellmut G Okun, Jürgen G Langhans, Claus‐Dieter Zierow, Johanna Wohlfeil, Sebastian A Olsavszky, Victor Schledzewski, Kai Goerdt, Sergij Koch, Philipp‐Sebastian Published in Hepatology (Baltimore, Md.) (01.08.2018)

“...Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes...”

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Toward precision medicine: tailoring interventional strategies based on noninvasive brain stimulation for motor recovery after stroke

by Koch, Philipp J Hummel, Friedhelm C Published in Current opinion in neurology (01.08.2017)

“...To support the recovery of disability and the reduced functional capacity influencing the independence of daily life after focal brain lesions like stroke, the...”

Journal Article

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

by Iefremova, Vira Manikakis, George Krefft, Olivia Jabali, Ammar Weynans, Kevin Wilkens, Ruven Marsoner, Fabio Brändl, Björn Müller, Franz-Josef Koch, Philipp Ladewig, Julia Published in Cell reports (Cambridge) (04.04.2017)

“...Miller-Dieker syndrome (MDS) is caused by a heterozygous deletion of chromosome 17p13.3 involving the genes LIS1 and YWHAE (coding for 14.3.3ε) and leads to...”

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Journal Article

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

by Koch, Philipp-Sebastian Olsavszky, Victor Ulbrich, Friederike Sticht, Carsten Demory, Alexandra Leibing, Thomas Henzler, Thomas Meyer, Mathias Zierow, Johanna Schneider, Sven Breitkopf-Heinlein, Katja Gaitantzi, Haristi Spencer-Dene, Bradley Arnold, Bernd Klapproth, Kay Schledzewski, Kai Goerdt, Sergij Géraud, Cyrill Published in Blood (26.01.2017)

“...Microvascular endothelial cells (ECs) display a high degree of phenotypic and functional heterogeneity among different organs. Organ-specific ECs control their...”

Journal Article

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration

by Ladewig, Julia Koch, Philipp Brüstle, Oliver Published in Nature neuroscience (01.01.2014)

“...Limited neuronal migration into host brain tissue is a key challenge in neural transplantation. We found that one important mechanism underlying this...”

Journal Article

Small molecules enable highly efficient neuronal conversion of human fibroblasts

by Ladewig, Julia Mertens, Jerome Kesavan, Jaideep Doerr, Jonas Poppe, Daniel Glaue, Finnja Herms, Stefan Wernet, Peter Kögler, Gesine Müller, Franz-Josef Koch, Philipp Brüstle, Oliver Published in Nature methods (01.06.2012)

“...Forced expression of proneural transcription factors has been shown to direct neuronal conversion of fibroblasts. Because neurons are postmitotic, conversion...”

Journal Article

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis

by Géraud, Cyrill Koch, Philipp-Sebastian Zierow, Johanna Klapproth, Kay Busch, Katrin Olsavszky, Victor Leibing, Thomas Demory, Alexandra Ulbrich, Friederike Diett, Miriam Singh, Sandhya Sticht, Carsten Breitkopf-Heinlein, Katja Richter, Karsten Karppinen, Sanna-Maria Pihlajaniemi, Taina Arnold, Bernd Rodewald, Hans-Reimer Augustin, Hellmut G Schledzewski, Kai Goerdt, Sergij Published in The Journal of clinical investigation (01.03.2017)

“...Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment. Microvascular ECs instruct...”

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Journal Article

Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues

by Boville, Christina E Scheele, Remkes A Koch, Philipp Brinkmann‐Chen, Sabine Buller, Andrew R Arnold, Frances H Published in Angewandte Chemie (International ed.) (05.11.2018)

“...Noncanonical amino acids (ncAAs) with dual stereocenters at the α and β positions are valuable precursors to natural products and therapeutics. Despite the...”

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Journal Article

Structural connectivity analyses in motor recovery research after stroke

by Koch, Philipp Schulz, Robert Hummel, Friedhelm C Published in Annals of clinical and translational neurology (01.03.2016)

“...Structural connectivity analyses by means of diffusion‐weighted imaging have substantially advanced the understanding of stroke‐related network alterations and...”

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Journal Article

GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro

by Schmid, Christian David Schledzewski, Kai Mogler, Carolin Waldburger, Nina Kalna, Viktoria Marx, Alexander Randi, Anna Maria Géraud, Cyrill Goerdt, Sergij Koch, Philipp-Sebastian Published in Biochemical and biophysical research communications (26.02.2018)

“...Endothelial cells (EC) along the vascular tree exhibit organ-specific angiodiversity. Compared to most other ECs, liver sinusoidal endothelial cells (LSEC)...”

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Journal Article

Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling

by Koch, Philipp, MD Kokaia, Zaal, PhD Lindvall, Olle, MD-PhD Brüstle, Oliver, MD Published in Lancet neurology (2009)

“...Summary The increasing availability of human pluripotent stem cells provides new prospects for neural-replacement strategies and disease-related basic...”

Journal Article

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

by Siegel, Gabriele Gerber, Hermeto Koch, Philipp Bruestle, Oliver Fraering, Patrick C Rajendran, Lawrence Published in Cell reports (Cambridge) (06.06.2017)

“...Alzheimer’s disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ40 is the most abundant form, neurotoxicity is mainly mediated...”

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Journal Article

Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling

by Wohlfeil, Sebastian A Häfele, Verena Dietsch, Bianca Schledzewski, Kai Winkler, Manuel Zierow, Johanna Leibing, Thomas Malek Mohammadi, Mona Heineke, Joerg Sticht, Carsten Olsavszky, Victor Koch, Philipp-Sebastian Géraud, Cyrill Goerdt, Sergij Published in Cancer research (Chicago, Ill.) (10.12.2018)

“...The interaction of tumor cells with organ-specific endothelial cells (EC) is an important step during metastatic progression. Notch signaling in organ-specific...”

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Journal Article

Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain

by Steinbeck, Julius A Steinbeck, Julius A Koch, Philipp Koch, Philipp Derouiche, Amin Derouiche, Amin Brüstle, Oliver Brüstle, Oliver Published in Cellular and molecular life sciences : CMLS (01.02.2012)

“...While the availability of pluripotent stem cells has opened new prospects for generating neural donor cells for nervous system repair, their capability to...”

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Journal Article

Correction to: A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri

by Baumgart, Mario Barth, Emanuel Savino, Aurora Groth, Marco Koch, Philipp Petzold, Andreas Arisi, Ivan Platzer, Matthias Marz, Manja Cellerino, Alessandro Published in BMC genomics (27.11.2019)

“...Following the publication of this article [1], the authors reported that the images of Figs. 1, 2 and 3 were published in the incorrect order, whereby they...”

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Journal Article

Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration

by Zhang, Xue-jun Olsavszky, Victor Yin, Yuhan Wang, Baocai Engleitner, Thomas Öllinger, Rupert Schledzewski, Kai Koch, Philipp-Sebastian Rad, Roland Schmid, Roland M Friess, Helmut Goerdt, Sergij Hüser, Norbert Géraud, Cyrill von Figura, Guido Hartmann, Daniel Published in The American journal of pathology (01.02.2020)

“...Liver sinusoidal endothelial cells (LSECs) control organ functions, metabolism, and development through the secretion of angiokines. LSECs express hepatocyte...”

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Journal Article

Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues

by Boville, Christina E Scheele, Remkes A Koch, Philipp Brinkmann‐Chen, Sabine Buller, Andrew R Arnold, Frances H Published in Angewandte Chemie (05.11.2018)

“...Noncanonical amino acids (ncAAs) with dual stereocenters at the α and β positions are valuable precursors to natural products and therapeutics. Despite the...”

Journal Article

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

by Ben Halima, Saoussen Mishra, Sabyashachi Raja, K. Muruga Poopathi Willem, Michael Baici, Antonio Simons, Kai Brüstle, Oliver Koch, Philipp Haass, Christian Caflisch, Amedeo Rajendran, Lawrence Published in Cell reports (Cambridge) (08.03.2016)

“...Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides...”

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Journal Article

Whole-brain 3D mapping of human neural transplant innervation

by Doerr, Jonas Schwarz, Martin Karl Wiedermann, Dirk Leinhaas, Anke Jakobs, Alina Schloen, Florian Schwarz, Inna Diedenhofen, Michael Braun, Nils Christian Koch, Philipp Peterson, Daniel A Kubitscheck, Ulrich Hoehn, Mathias Brüstle, Oliver Published in Nature communications (19.01.2017)

“...While transplantation represents a key tool for assessing in vivo functionality of neural stem cells and their suitability for neural repair, little is known...”

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