Search Results - "Lyle J. Palmer"

Journal Article

Precision Radiology: Predicting longevity using feature engineering and deep learning methods in a radiomics framework

by Oakden-Rayner, Luke Carneiro, Gustavo Bessen, Taryn Nascimento, Jacinto C Bradley, Andrew P Palmer, Lyle J Published in Scientific reports (10.05.2017)

“...Precision medicine approaches rely on obtaining precise knowledge of the true state of health of an individual patient, which results from a combination of...”

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Journal Article

The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention

by Dummer, Trevor J.B., PhD Awadalla, Philip, PhD Boileau, Catherine, PhD Craig, Camille, MSc Fortier, Isabel, PhD Goel, Vivek, MD Hicks, Jason M.T., MSc Jacquemont, Sébastien, MD Knoppers, Bartha Maria, PhD Zawati, Ma’n, LLM Le, Nhu, PhD McDonald, Treena, MSc McLaughlin, John, PhD Mes-Masson, Anne-Marie, PhD Nuyt, Anne-Monique, MD Palmer, Lyle J., PhD Parker, Louise, PhD Purdue, Mark, PhD Robson, Paula J., PhD Vena, Jennifer, PhD Spinelli, John J., PhD Thompson, David, MSc Published in Canadian Medical Association journal (CMAJ) (2018)

“...ABSTRACT BACKGROUND Understanding the complex interaction of risk factors that increase the likelihood of developing common diseases is challenging. The...”

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Journal Article

Fine Mapping versus Replication in Whole-Genome Association Studies

by Clarke, Geraldine M Carter, Kim W Palmer, Lyle J Morris, Andrew P Cardon, Lon R Published in American journal of human genetics (2007)

“...Association replication studies have a poor track record and, even when successful, often claim association with different markers, alleles, and phenotypes...”

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Journal Article

UK Biobank: bank on it

by Palmer, Lyle J Published in The Lancet (British edition) (2007)

Journal Article

A vision for chronic disease prevention and intervention research: Report from a workshop

by Fredrick D. Ashbury Julian Little John P.A. Ioannidis Nancy Kreiger Lyle J. Palmer Clare Relton Peter Taylor Published in Canadian journal of public health (01.04.2014)

“...The Population Studies Research Network of Cancer Care Ontario hosted a strategic planning workshop to establish an agenda for a prevention intervention...”

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Journal Article

Neighborhood greenspace and health in a large urban center

by Kardan, Omid Gozdyra, Peter Misic, Bratislav Moola, Faisal Palmer, Lyle J Paus, Tomáš Berman, Marc G Published in Scientific reports (09.07.2015)

“...Studies have shown that natural environments can enhance health and here we build upon that work by examining the associations between comprehensive greenspace...”

Journal Article

Population stratification and spurious allelic association

by Cardon, Lon R Palmer, Lyle J Published in The Lancet (British edition) (2003)

“...Great efforts and expense have been expended in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease...”

Journal Article

The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI

by Webster, Rebecca J Warrington, Nicole M Beilby, John P Frayling, Timothy M Palmer, Lyle J Published in BMC medical genetics (08.10.2010)

“...Variation in the effects of genetic variants on physiological traits over time or with age may alter the trajectories of these traits. However, few studies...”

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Journal Article

The genetics of obstructive sleep apnoea

by Mukherjee, Sutapa Saxena, Richa Palmer, Lyle J Published in Respirology (Carlton, Vic.) (01.01.2018)

“...ABSTRACT Obstructive sleep apnoea (OSA) is a common chronic disease and is associated with high social and economic costs. OSA is heritable, and there is...”

Journal Article

Genetic epidemiology 4 Shaking the tree : mapping complex disease genes with linkage disequilibrium

by PALMER, Lyle J CARDON, Lon R Published in The Lancet (British edition) (2005)

“...Much effort and expense are being spent internationally to detect genetic polymorphisms contributing to susceptibility to complex human disease. Concomitantly,...”

Journal Article

Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids

by SCHAEFFER, Linda GOHIKE, Henning MÜLLER, Martina HEID, Iris M PALMER, Lyle J KOMPAUER, Iris DEMMELMAIR, Hans ILLIG, Thomas KOLETZKO, Berthold HEINRICH, Joachim Published in Human molecular genetics (2006)

“...Fatty acid composition in membranes plays an important role in cellular processes and has shown to be associated with the aetiology of several complex diseases...”

Journal Article

Decline in Lung Function in the Busselton Health Study: The Effects of Asthma and Cigarette Smoking

by James, Alan L Palmer, Lyle J Kicic, Elizabeth Maxwell, Peta S Lagan, Sharon E Ryan, Gerard F Musk, A. William Published in American journal of respiratory and critical care medicine (15.01.2005)

“...Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in...”

Journal Article

Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease

by Loffler, Kelly A Heeley, Emma Freed, Ruth Meng, Rosie Bittencourt, Lia R Gonzaga Carvalho, Carolina C Chen, Rui Hlavac, Michael Liu, Zhihong Lorenzi-Filho, Geraldo Luo, Yuanming McArdle, Nigel Mukherjee, Sutapa Yap, Hooi Shan Zhang, Xilong Palmer, Lyle J Anderson, Craig S McEvoy, R Doug Drager, Luciano F Published in Diabetes care (14.04.2020)

“...Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can...”

Journal Article

Association between liver‐specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease

by Adams, Leon A White, Scott W Marsh, Julie A Lye, Stephen J Connor, Kristin L Maganga, Richard Ayonrinde, Oyekoya T Olynyk, John K Mori, Trevor A Beilin, Lawrence J Palmer, Lyle J Hamdorf, Jeffrey M Pennell, Craig E Published in Hepatology (Baltimore, Md.) (01.02.2013)

“...Genetic factors account for a significant proportion of the phenotypic variance of nonalcoholic fatty liver disease (NAFLD); however, very few predisposing...”

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Journal Article

Effect of Obstructive Sleep Apnea Treatment on Renal Function in Patients with Cardiovascular Disease

by Loffler, Kelly A Heeley, Emma Freed, Ruth Anderson, Craig S Brockway, Ben Corbett, Alastair Chang, Catherina L Douglas, James A Ferrier, Katherine Graham, Neil Hamilton, Garun S Hlavac, Michael McArdle, Nigel McLachlan, John Mukherjee, Sutapa Naughton, Matthew T Thien, Francis Young, Alan Grunstein, Ronald R Palmer, Lyle J Woodman, Richard J Hanly, Patrick J McEvoy, R Doug Published in American journal of respiratory and critical care medicine (01.12.2017)

“...Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. To...”

Journal Article

Diminished Lipoxin Biosynthesis in Severe Asthma

by Levy, Bruce D Bonnans, Caroline Silverman, Eric S Palmer, Lyle J Marigowda, Gautham Israel, Elliot Severe Asthma Research Program, National Heart, Lung, and Blood Institute Published in American journal of respiratory and critical care medicine (01.10.2005)

“...Severe asthma is characterized by increased airway inflammation that persists despite therapy with corticosteroids. It is not, however, merely an exaggeration...”

Journal Article

High prevalence of undiagnosed obstructive sleep apnoea in the general population and methods for screening for representative controls

by Simpson, Laila Simpson, Laila Hillman, David R Hillman, David R Cooper, Matthew N Cooper, Matthew N Ward, Kim L Ward, Kim L Hunter, Michael Hunter, Michael Cullen, Stewart Cullen, Stewart James, Alan James, Alan Palmer, Lyle J Palmer, Lyle J Mukherjee, Sutapa Mukherjee, Sutapa Eastwood, Peter Eastwood, Peter Published in Sleep and Breathing (01.09.2013)

“...Undiagnosed obstructive sleep apnoea (OSA) in the community makes comparisons of OSA subjects with control samples from the general population problematic...”

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Toward a roadmap in global biobanking for health

by HARRIS, Jennifer R BURTON, Paul FORTIER, Isabel HAINAUT, Pierre HEWITT, Robert KAYE, Jane LITTON, Jan-Eric METSPALU, Andres OLLIER, Bill PALMER, Lyle J PALOTIE, Aarno PASTERK, Markus KNOPPERS, Bartha Maria PEROLA, Markus RIEGMAN, Peter Hj OMMEN, Gert-Janvan YUILLE, Martin ZATLOUKAL, Kurt LINDPAINTNER, Klaus BLEDSOE, Marianna BROOKES, Anthony J BUDIN-LJØSNE, Isabelle CHISHOLM, Rex COX, David DESCHENES, Mylène Published in European journal of human genetics : EJHG (2012)

“...Biobanks can have a pivotal role in elucidating disease etiology, translation, and advancing public health. However, meeting these challenges hinges on a...”

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C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

by Timpson, Nicholas J Lawlor, Debbie A Harbord, Roger M Gaunt, Tom R Day, Ian NM Palmer, Lyle J Hattersley, Andrew T Ebrahim, Shah Lowe, Gordon DO Rumley, Ann Smith, George Davey Published in The Lancet (British edition) (03.12.2005)

“...Circulating C-reactive protein (CRP) is associated with the metabolic syndrome and might be causally linked to it. Our aim was to generate estimates of the...”

Journal Article

JLIN: a java based linkage disequilibrium plotter

by Carter, Kim W McCaskie, Pamela A Palmer, Lyle J Published in BMC bioinformatics (09.02.2006)

“...A great deal of effort and expense are being expended internationally in attempts to detect genetic polymorphisms contributing to susceptibility to complex...”

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