Search Results - "MISMATCH"

Journal Article

Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal

by Guarné, Alba Charbonnier, Jean-Baptiste Published in Progress in biophysics and molecular biology (01.03.2015)

“...DNA mismatch repair (MMR) is a conserved pathway that safeguards genome integrity by correcting replication errors. The coordinated actions of two proteins...”

Journal Article

β Clamp Directs Localization of Mismatch Repair in Bacillus subtilis

by Simmons, Lyle A Davies, Bryan W Grossman, Alan D Walker, Graham C Published in Molecular cell (2008)

“...MutS homologs function in several cellular pathways including mismatch repair (MMR), the process by which mismatches introduced during DNA replication are...”

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Journal Article

Importance of base-pair opening for mismatch recognition

by Bouchal, Tomáš Durník, Ivo Illík, Viktor Réblová, Kamila Kulhánek, Petr Published in Nucleic acids research (18.11.2020)

“...Mismatch repair is a highly conserved cellular pathway responsible for repairing mismatched dsDNA. Errors are detected by the MutS enzyme, which most likely...”

Journal Article

Balancing repair and tolerance of DNA damage caused by alkylating agents

by Fu, Dragony Calvo, Jennifer A Samson, Leona D Published in Nature reviews. Cancer (12.01.2012)

“...Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to...”

Journal Article

Conservation, mismatch and the research-implementation gap

by Jarvis, R. M Borrelle, S. B Breen, B. Bollard Towns, D. R Published in Pacific conservation biology (2015-00-00)

“...Despite calls to better link research and practice, the gap between knowing and doing continues to limit conservation success. Here we report on the outcomes...”

Journal Article

LDH‐A negatively regulates dMMR in colorectal cancer

by Zhang, Yongjie Li, Juan Wang, Bo Chen, Ting Chen, Yun Ma, Wen Published in Cancer science (01.08.2021)

“...Although immune checkpoint inhibitors (ICIs) have achieved unprecedented success in dMMR tumors, pMMR tumors accounting for 85% of colorectal cancer (CRC)...”

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Journal Article

ATP Alters the Diffusion Mechanics of MutS on Mismatched DNA

by Cho, Won-Ki Jeong, Cherlhyun Kim, Daehyung Chang, Minhyeok Song, Kyung-Mi Hanne, Jeungphill Ban, Changill Fishel, Richard Lee, Jong-Bong Published in Structure (London) (03.07.2012)

“...The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps on DNA: a transient mismatch searching clamp (∼1 s) and an...”

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Journal Article

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops

by Gupta, Shikha Gellert, Martin Yang, Wei Published in Nature structural & molecular biology (18.12.2011)

“...DNA mismatch repair corrects replication errors, thus reducing mutation rates and microsatellite instability. Genetic defects in this pathway cause Lynch...”

Journal Article

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

by Meier, Bettina Volkova, Nadezda V Hong, Ye Schofield, Pieta Campbell, Peter J Gerstung, Moritz Gartner, Anton Published in Genome research (01.05.2018)

“...Throughout their lifetime, cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome. DNA...”

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Journal Article

Spatial coupling between DNA replication and mismatch repair in Caulobacter crescentus

by Chai, Tiancong Terrettaz, Céline Collier, Justine Published in Nucleic acids research (06.04.2021)

“...Abstract The DNA mismatch repair (MMR) process detects and corrects replication errors in organisms ranging from bacteria to humans. In most bacteria, it is...”

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Journal Article

Mismatch unemployment

by Sahin, Aysegül Song, Joseph Topa, Giorgio Violante, Giovanni L Published in The American economic review (2014)

“...We develop a framework where mismatch between vacancies and job seekers across sectors translates into higher unemployment by lowering the aggregate...”

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Journal Article

Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas

by Vanoli, Alessandro Grillo, Federica Guerini, Camilla Neri, Giuseppe Arpa, Giovanni Klersy, Catherine Nesi, Gabriella Giuffrida, Paolo Sampietro, Gianluca Ardizzone, Sandro Fociani, Paolo Fiocca, Roberto Latella, Giovanni Sessa, Fausto D'Errico, Antonietta Malvi, Deborah Mescoli, Claudia Rugge, Massimo Ferrero, Stefano Poggioli, Gilberto Rizzello, Fernando Macciomei, Maria C Santini, Donatella Volta, Umberto De Giorgio, Roberto Caio, Giacomo Calabrò, Antonio Ciacci, Carolina D'Armiento, Maria Rizzo, Aroldo Solina, Gaspare Martino, Michele Tonelli, Francesco Villanacci, Vincenzo Cannizzaro, Renato Canzonieri, Vincenzo Florena, Ada Maria Biancone, Livia Monteleone, Giovanni Caronna, Roberto Ciardi, Antonio Elli, Luca Caprioli, Flavio Vecchi, Maurizio D'Incà, Renata Zingone, Fabiana D'Odorico, Anna Lenti, Marco Vincenzo Oreggia, Barbara Reggiani Bonetti, Luca Giannone, Antonino Giulio Orlandi, Augusto Barresi, Valeria Ciccocioppo, Rachele Amodeo, Giuseppe Biletta, Elena Luinetti, Ombretta Pedrazzoli, Paolo Pietrabissa, Andrea Corazza, Gino Roberto Solcia, Enrico Paulli, Marco Di Sabatino, Antonio Published in Annals of surgical oncology (01.02.2021)

“...Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in...”

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