Search Results - "Martins, Ralph N"

Journal Article

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a lon...

by Burnham, Samantha C, PhD Bourgeat, Pierrick, PhD Doré, Vincent, PhD Savage, Greg, Prof Brown, Belinda, PhD Laws, Simon, PhD Maruff, Paul, Prof Salvado, Olivier, PhD Ames, David, Prof Martins, Ralph N, Prof Masters, Colin L, Prof Rowe, Christopher C, Prof Villemagne, Victor L, Dr Published in Lancet neurology (2016)

“...Summary Background Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50–60% of cognitively healthy elderly individuals (aged...”

Journal Article

The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men

by Eka J. Wahjoepramono Prita R. Asih Vilia Aniwiyanti Kevin Taddei Satvinder S. Dhaliwal Stephanie J. Fuller Jonathan Foster Malcolm Carruthers Giuseppe Verdile Hamid R Sohrabi Ralph N. Martins Published in CNS & neurological disorders drug targets (01.04.2016)

“...Reduction in testosterone levels in men during aging is associated with cognitive decline and risk of dementia. Animal studies have shown benefits for...”

Journal Article

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies

by Verdile, Giuseppe Asih, Prita R Barron, Anna M Wahjoepramono, Eka.J Ittner, Lars M Martins, Ralph N Published in Hormones and behavior (01.11.2015)

“...This article is part of a Special Issue “SBN 2014”. Hormonal changes associated with ageing have been implicated in the pathogenesis of Alzheimer's disease...”

Journal Article

Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease

by Müller, Stephan Preische, Oliver Sohrabi, Hamid R Gräber, Susanne Jucker, Mathias Dietzsch, Janko Ringman, John M Martins, Ralph N McDade, Eric Schofield, Peter R Ghetti, Bernardino Rossor, Martin Graff-Radford, Neill R Levin, Johannes Galasko, Douglas Quaid, Kimberly A Salloway, Stephen Xiong, Chengjie Benzinger, Tammie Buckles, Virginia Masters, Colin L Sperling, Reisa Bateman, Randall J Morris, John C Laske, Christoph Published in Scientific reports (27.04.2017)

“...The relationship between body-mass index (BMI) and Alzheimer´s disease (AD) has been extensively investigated. However, BMI alterations in preclinical...”

Fulltext

eBook

Neurodegeneration and Alzheimer's Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle

by Martins, Ralph N Brennan, Charles S Fernando, Binosha Brennan, Margaret A Fuller, Stephanie J
2019

“...Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer's and other neurogenerative diseases Diet is widely...”

Journal Article

Alzheimer's Disease and the Early Signs of Age-Related Macular Degeneration

by Shaun Frost Robyn Guymer Khin Zaw Aung S. Lance Macaulay Hamid R Sohrabi Pierrick Bourgeat Olivier Salvado Christopher C. Rowe David Ames Colin L. Masters Ralph N. Martins Yogesan Kanagasingam the AIBL Research Group Published in Current Alzheimer research (01.11.2016)

“...This study investigated signs of age related macular degeneration (AMD) in Alzheimer's disease (AD). These age-related diseases primarily affect different...”

Journal Article

Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease

by Chatterjee, Pratishtha Pedrini, Steve Stoops, Erik Goozee, Kathryn Villemagne, Victor L Asih, Prita R Verberk, Inge M W Dave, Preeti Taddei, Kevin Sohrabi, Hamid R Zetterberg, Henrik Blennow, Kaj Teunissen, Charlotte E Vanderstichele, Hugo M Martins, Ralph N Published in Translational psychiatry (11.01.2021)

“...Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in blood samples, and has been associated with Alzheimer's disease...”

Fulltext

Journal Article

Modulation of Retinal Arteriolar Central Reflection by APOE Genotype

by Shaun Frost Alauddin Bhuiyan David Offerman James D. Doecke S. Lance Macaulay Hamid R. Sohrabi David Ames Colin Masters Ralph N. Martins Yogesan Kanagasingam AIBL Research Group Published in Current Alzheimer research (01.09.2017)

“...Objective: This study investigated the retinal arteriolar central reflex (CR, the central reflection observed in photographs of retinal vessels), which may...”

Journal Article

Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry

by Frost, Shaun Robinson, Liam Rowe, Christopher C Ames, David Masters, Colin L Taddei, Kevin Rainey-Smith, Stephanie R Martins, Ralph N Kanagasingam, Yogesan
edited by Cerviño, Alejandro
Published in Journal of ophthalmology (15.08.2017)

“...Cortical cholinergic deficiency is prominent in Alzheimer’s disease (AD), and published findings of diminished pupil flash response in AD suggest that this...”

Fulltext

Journal Article

Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complai...

by Cyarto, Elizabeth V Lautenschlager, Nicola T Desmond, Patricia M Ames, David Szoeke, Cassandra Salvado, Olivier Sharman, Matthew J Ellis, Kathryn A Phal, Pramit M Masters, Colin L Rowe, Christopher C Martins, Ralph N Cox, Kay L Published in BMC psychiatry (11.10.2012)

“...Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive...”

Fulltext

Journal Article

Pupil Response Biomarkers Distinguish Amyloid Precursor Protein Mutation Carriers from Non-Carriers

by Shaun M. Frost Yogesan Kanagasingam Hamid R. Sohrabi Kevin Taddei Randall Bateman John Morris Tammie Benzinger Alison Goate Colin L. Masters Ralph N. Martins Published in Current Alzheimer research (01.10.2013)

“...Context: Alzheimer's disease (AD) is usually only diagnosed many years after pathology begins. Earlier detection would allow emerging interventions to have a...”

Journal Article

PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer's Disease Brain

by Bharadwaj, Prashant Martins, Ralph N Published in Journal of Alzheimer's disease (2020-00-00)

“...Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in...”

Journal Article

Understanding the Link between Dementia and Diabetes

by Martins, Ralph N Published in Journal of Alzheimer's disease (2017-00-00)

Journal Article

Lipidomic profiles in diabetes and dementia

by Huynh, Kevin Martins, Ralph N Meikle, Peter J Published in Journal of Alzheimer's disease (2017-00-00)

“...Lipids are a diverse class of hydrophobic and amphiphilic molecules which make up the bulk of most biological systems and are essential for human life. The...”

Journal Article

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

by Giuseppe Verdile Kevin N. Keane Vinicius F. Cruzat Sandra Medic Miheer Sabale Joanne Rowles Nadeeja Wijesekara Ralph N. Martins Paul E. Fraser Philip Newsholme
edited by Macciò, Antonio
Published in Mediators of inflammation (01.12.2015)

“...Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent...”

Fulltext

Journal Article

Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis

by Dhiman, Kunal Blennow, Kaj Zetterberg, Henrik Martins, Ralph N Gupta, Veer Bala Published in Cellular and molecular life sciences : CMLS (01.05.2019)

“...Alzheimer's disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial...”

Journal Article

Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing C...

by Shah, Tejal M Weinborn, Michael Verdile, Giuseppe Sohrabi, Hamid R Martins, Ralph N Published in Neuropsychology review (01.03.2017)

“...Successfully assisting older adults to maintain or improve cognitive function, particularly when they are dealing with neurodegenerative disorders such as...”

Fulltext

Journal Article

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

by Martins, Ian J Berger, Tamar Sharman, Matthew J Verdile, Giuseppe Fuller, Stephanie J Martins, Ralph N Published in Journal of neurochemistry (01.12.2009)

“...Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions of people worldwide. Apart from age, the major risk factor...”

Fulltext

Journal Article

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

by Lee, Seonjoo Viqar, Fawad Zimmerman, Molly E Narkhede, Atul Tosto, Giuseppe Benzinger, Tammie L.S Marcus, Daniel S Fagan, Anne M Goate, Alison Fox, Nick C Cairns, Nigel J Holtzman, David M Buckles, Virginia Ghetti, Bernardino McDade, Eric Martins, Ralph N Saykin, Andrew J Masters, Colin L Ringman, John M Ryan, Natalie S Förster, Stefan Laske, Christoph Schofield, Peter R Sperling, Reisa A Salloway, Stephen Correia, Stephen Jack, Clifford Weiner, Michael Bateman, Randall J Morris, John C Mayeux, Richard Brickman, Adam M Published in Annals of neurology (01.06.2016)

“...Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐weighted magnetic resonance imaging (MRI) scans that most commonly reflect...”

Fulltext

Journal Article

Prostate cancer: Increased dementia risk following androgen deprivation therapy?

by Martins, Ralph N Gandy, Sam Published in Nature reviews. Urology (01.04.2016)

1
2
3
4
5
6
7
8
9
10
11
Next »
[37]

Narrow search