-
1by Guarné, Alba Charbonnier, Jean-Baptiste Published in Progress in biophysics and molecular biology (01.03.2015)“...DNA mismatch repair (MMR) is a conserved pathway that safeguards genome integrity by correcting replication errors. The coordinated actions of two proteins...”
-
2by Simmons, Lyle A Davies, Bryan W Grossman, Alan D Walker, Graham C Published in Molecular cell (2008)“...MutS homologs function in several cellular pathways including mismatch repair (MMR), the process by which mismatches introduced during DNA replication are...”
-
3Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signallingby Qiu, Ruoyi DeRocco, Vanessa C Harris, Credle Sharma, Anushi Hingorani, Manju M Erie, Dorothy A Weninger, Keith R Published in The EMBO journal (30.05.2012)“...MutS protein recognizes mispaired bases in DNA and targets them for mismatch repair. Little is known about the transient conformations of MutS as it signals...”
-
4by Bouchal, Tomáš Durník, Ivo Illík, Viktor Réblová, Kamila Kulhánek, Petr Published in Nucleic acids research (18.11.2020)“...Mismatch repair is a highly conserved cellular pathway responsible for repairing mismatched dsDNA. Errors are detected by the MutS enzyme, which most likely...”
-
5by Chalabi, Myriam Fanchi, Lorenzo F Dijkstra, Krijn K van den Berg, Jose G Aalbers, Arend G Sikorska, Karolina Lopez-Yurda, Marta Grootscholten, Cecile Beets, Geerard L Snaebjornsson, Petur Maas, Monique Mertz, Marjolijn Veninga, Vivien Bounova, Gergana Broeks, Annegien Beets-Tan, Regina G de Wijkerslooth, Thomas R van Lent, Anja U Marsman, Henik A Nuijten, Elvira Kok, Niels F Kuiper, Maria Verbeek, Wieke H Kok, Marleen Van Leerdam, Monique E Schumacher, Ton N Voest, Emile E Haanen, John B Published in Nature medicine (01.04.2020)“...PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR)...”
-
6“...Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to...”
-
7by Jarvis, R. M Borrelle, S. B Breen, B. Bollard Towns, D. R Published in Pacific conservation biology (2015-00-00)“...Despite calls to better link research and practice, the gap between knowing and doing continues to limit conservation success. Here we report on the outcomes...”
-
8by st, Jarno van Boxtel, Ruben Blokzijl, Francis Mizutani, Tomohiro Sasaki, Nobuo Sasselli, Valentina de Ligt, Joep Behjati, Sam Grolleman, Judith E van Wezel, Tom Nik-Zainal, Serena Kuiper, Roland P Cuppen, Edwin Clevers, Hans Published in Science (American Association for the Advancement of Science) (13.10.2017)“...Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold...”
-
9by Cho, Won-Ki Jeong, Cherlhyun Kim, Daehyung Chang, Minhyeok Song, Kyung-Mi Hanne, Jeungphill Ban, Changill Fishel, Richard Lee, Jong-Bong Published in Structure (London) (03.07.2012)“...The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps on DNA: a transient mismatch searching clamp (∼1 s) and an...”
-
10by Gupta, Shikha Gellert, Martin Yang, Wei Published in Nature structural & molecular biology (18.12.2011)“...DNA mismatch repair corrects replication errors, thus reducing mutation rates and microsatellite instability. Genetic defects in this pathway cause Lynch...”
-
11by Hodges, Tiffany R Ott, Martina Xiu, Joanne Gatalica, Zoran Swensen, Jeff Zhou, Shouhao Huse, Jason T de Groot, John Li, Shulin Overwijk, Willem W Spetzler, David Heimberger, Amy B Published in Neuro-oncology (Charlottesville, Va.) (01.08.2017)“...Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of potential predictive biomarkers is unknown in...”
-
12by Ishida, Hisashi Matsumoto, Atsushi Published in Proteins, structure, function, and bioinformatics (01.09.2016)“...ABSTRACT In order to understand how MutS recognizes mismatched DNA and induces the reaction of DNA repair using ATP, the dynamics of the complexes of MutS...”
-
13by Cristovao, Michele Sisamakis, Evangelos Hingorani, Manju Marx, Aneas Jung, Caroline Rothwell, Paul Seidel, Claus A Friedhoff, Peter Published in Nucleic acids research (01.07.2012)“...textabstractMismatch repair (MMR) corrects replication errors such as mismatched bases and loops in DNA. The evolutionarily conserved dimeric MMR protein MutS...”
-
14by Sahin, Aysegül Song, Joseph Topa, Giorgio Violante, Giovanni L Published in The American economic review (2014)“...We develop a framework where mismatch between vacancies and job seekers across sectors translates into higher unemployment by lowering the aggregate...”
-
15by Nirwal, Shivlee Kulkarni, Dhananjaya S Sharma, Amit Rao, Desirazu N Nair, Deepak T Published in Nucleic acids research (09.01.2018)“...Abstract The DNA mismatch repair (MMR) pathway removes errors that appear during genome replication. MutS is the primary mismatch sensor and forms an...”
-
16by Walsh, Michael D Jayasekara, Harindra Huang, Alvin Winship, Ingrid M Buchanan, Daniel D Published in Australasian journal of dermatology (01.05.2019)“...Background/Objectives Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch...”
-
17“...A frequency-interleaving-based multichannel analogue-to-digitial converter (ADC) with mismatch compensation is presented, which is immune from the time skew...”
-
18by Jiricny, Josef Published in Cold Spring Harbor perspectives in biology (01.04.2013)“...The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by...”
-
19by Mills, Anne M Dill, Erik A Moskaluk, Christopher A Dziegielewski, Jaroslaw Bullock, Tim N Dillon, Patrick M Published in The American journal of surgical pathology (01.02.2018)“...Mismatch repair (MMR) deficiency in solid tumors has recently been linked to susceptibility to immunotherapies targeting the programmed cell death-1...”