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  • Your search results: "Mismatch"
Showing 1 - 20 results of 30,937 for search '"Mismatch"', query time: 1.88s Narrow search
  • 1
    Cover Image Journal Article
    Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal
    by Guarné, Alba   Charbonnier, Jean-Baptiste Published in Progress in biophysics and molecular biology (01.03.2015)
    “...DNA mismatch repair (MMR) is a conserved pathway that safeguards genome integrity by correcting replication errors. The coordinated actions of two proteins...”
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  • 2
    Cover Image Journal Article
    β Clamp Directs Localization of Mismatch Repair in Bacillus subtilis
    by Simmons, Lyle A   Davies, Bryan W   Grossman, Alan D   Walker, Graham C Published in Molecular cell (2008)
    “...MutS homologs function in several cellular pathways including mismatch repair (MMR), the process by which mismatches introduced during DNA replication are...”
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  • 3
    Cover Image Journal Article
    Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling
    by Qiu, Ruoyi   DeRocco, Vanessa C   Harris, Credle   Sharma, Anushi   Hingorani, Manju M   Erie, Dorothy A   Weninger, Keith R Published in The EMBO journal (30.05.2012)
    “...MutS protein recognizes mispaired bases in DNA and targets them for mismatch repair. Little is known about the transient conformations of MutS as it signals...”
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  • 4
    Cover Image Journal Article
    Importance of base-pair opening for mismatch recognition
    by Bouchal, Tomáš   Durník, Ivo   Illík, Viktor   Réblová, Kamila   Kulhánek, Petr Published in Nucleic acids research (18.11.2020)
    “...Mismatch repair is a highly conserved cellular pathway responsible for repairing mismatched dsDNA. Errors are detected by the MutS enzyme, which most likely...”
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  • 5
    Cover Image Journal Article
    Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
    by Chalabi, Myriam   Fanchi, Lorenzo F   Dijkstra, Krijn K   van den Berg, Jose G   Aalbers, Arend G   Sikorska, Karolina   Lopez-Yurda, Marta   Grootscholten, Cecile   Beets, Geerard L   Snaebjornsson, Petur   Maas, Monique   Mertz, Marjolijn   Veninga, Vivien   Bounova, Gergana   Broeks, Annegien   Beets-Tan, Regina G   de Wijkerslooth, Thomas R   van Lent, Anja U   Marsman, Henik A   Nuijten, Elvira   Kok, Niels F   Kuiper, Maria   Verbeek, Wieke H   Kok, Marleen   Van Leerdam, Monique E   Schumacher, Ton N   Voest, Emile E   Haanen, John B Published in Nature medicine (01.04.2020)
    “...PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR)...”
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  • 6
    Cover Image Journal Article
    Balancing repair and tolerance of DNA damage caused by alkylating agents
    by Fu, Dragony   Calvo, Jennifer A   Samson, Leona D Published in Nature reviews. Cancer (12.01.2012)
    “...Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to...”
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  • 7
    Cover Image Journal Article
    Conservation, mismatch and the research-implementation gap
    by Jarvis, R. M   Borrelle, S. B   Breen, B. Bollard   Towns, D. R Published in Pacific conservation biology (2015-00-00)
    “...Despite calls to better link research and practice, the gap between knowing and doing continues to limit conservation success. Here we report on the outcomes...”
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  • 8
    Cover Image Journal Article
    Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
    by st, Jarno   van Boxtel, Ruben   Blokzijl, Francis   Mizutani, Tomohiro   Sasaki, Nobuo   Sasselli, Valentina   de Ligt, Joep   Behjati, Sam   Grolleman, Judith E   van Wezel, Tom   Nik-Zainal, Serena   Kuiper, Roland P   Cuppen, Edwin   Clevers, Hans Published in Science (American Association for the Advancement of Science) (13.10.2017)
    “...Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold...”
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  • 9
    Cover Image Journal Article
    ATP Alters the Diffusion Mechanics of MutS on Mismatched DNA
    by Cho, Won-Ki   Jeong, Cherlhyun   Kim, Daehyung   Chang, Minhyeok   Song, Kyung-Mi   Hanne, Jeungphill   Ban, Changill   Fishel, Richard   Lee, Jong-Bong Published in Structure (London) (03.07.2012)
    “...The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps on DNA: a transient mismatch searching clamp (∼1 s) and an...”
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  • 10
    Cover Image Journal Article
    Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops
    by Gupta, Shikha   Gellert, Martin   Yang, Wei Published in Nature structural & molecular biology (18.12.2011)
    “...DNA mismatch repair corrects replication errors, thus reducing mutation rates and microsatellite instability. Genetic defects in this pathway cause Lynch...”
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  • 11
    Cover Image Journal Article
    Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy
    by Hodges, Tiffany R   Ott, Martina   Xiu, Joanne   Gatalica, Zoran   Swensen, Jeff   Zhou, Shouhao   Huse, Jason T   de Groot, John   Li, Shulin   Overwijk, Willem W   Spetzler, David   Heimberger, Amy B Published in Neuro-oncology (Charlottesville, Va.) (01.08.2017)
    “...Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of potential predictive biomarkers is unknown in...”
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  • 12
    Cover Image Journal Article
    Mechanism for verification of mismatched and homoduplex DNAs by nucleotides‐bound MutS analyzed by molecular dynamics simulations
    by Ishida, Hisashi   Matsumoto, Atsushi Published in Proteins, structure, function, and bioinformatics (01.09.2016)
    “...ABSTRACT In order to understand how MutS recognizes mismatched DNA and induces the reaction of DNA repair using ATP, the dynamics of the complexes of MutS...”
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  • 13
    Cover Image Journal Article
    Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA
    by Cristovao, Michele   Sisamakis, Evangelos   Hingorani, Manju   Marx, Aneas   Jung, Caroline   Rothwell, Paul   Seidel, Claus A   Friedhoff, Peter Published in Nucleic acids research (01.07.2012)
    “...textabstractMismatch repair (MMR) corrects replication errors such as mismatched bases and loops in DNA. The evolutionarily conserved dimeric MMR protein MutS...”
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  • 14
    Cover Image Journal Article
    Mismatch unemployment
    by Sahin, Aysegül   Song, Joseph   Topa, Giorgio   Violante, Giovanni L Published in The American economic review (2014)
    “...We develop a framework where mismatch between vacancies and job seekers across sectors translates into higher unemployment by lowering the aggregate...”
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  • 15
    Cover Image Journal Article
    Mechanism of formation of a toroid around DNA by the mismatch sensor protein
    by Nirwal, Shivlee   Kulkarni, Dhananjaya S   Sharma, Amit   Rao, Desirazu N   Nair, Deepak T Published in Nucleic acids research (09.01.2018)
    “...Abstract The DNA mismatch repair (MMR) pathway removes errors that appear during genome replication. MutS is the primary mismatch sensor and forms an...”
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  • 16
    Cover Image Journal Article
    Clinico‐pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service
    by Walsh, Michael D   Jayasekara, Harindra   Huang, Alvin   Winship, Ingrid M   Buchanan, Daniel D Published in Australasian journal of dermatology (01.05.2019)
    “...Background/Objectives Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch...”
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  • 17
    Cover Image Journal Article
    Design of frequency-interleaved ADC with mismatch compensation
    by Qiu, L   Zheng, Y.J   Siek, L Published in Electronics letters (24.04.2014)
    “...A frequency-interleaving-based multichannel analogue-to-digitial converter (ADC) with mismatch compensation is presented, which is immune from the time skew...”
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  • 18
    Cover Image Journal Article
    Postreplicative mismatch repair
    by Jiricny, Josef Published in Cold Spring Harbor perspectives in biology (01.04.2013)
    “...The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by...”
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  • 19
    Cover Image Journal Article
    The Relationship Between Mismatch Repair Deficiency and PD-L1 Expression in Breast Carcinoma
    by Mills, Anne M   Dill, Erik A   Moskaluk, Christopher A   Dziegielewski, Jaroslaw   Bullock, Tim N   Dillon, Patrick M Published in The American journal of surgical pathology (01.02.2018)
    “...Mismatch repair (MMR) deficiency in solid tumors has recently been linked to susceptibility to immunotherapies targeting the programmed cell death-1...”
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  • 20
    Cover Image Journal Article
    Musical prediction error responses similarly reduced by predictive uncertainty in musicians and non-musicians
    by Quiroga-Martinez, DR   Hansen, NC   Hojlund, A   Pearce, M   Brattico, E   Vuust, P
    23.12.2019
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