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Nature structural & molecular biology

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Nature structural and molecular biology [electronic resource]

by Nature Publishing Group
Published in Nature structural & molecular biology

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Nature structural and molecular biology

Published in Nature structural & molecular biology

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Nature Structural Biology

Journal Article

Nature structural and molecular biology

by Nature Publishing Group
Published in Nature structural & molecular biology

Journal Article

Nature structural and molecular biology [electronic resource]

by EBSCO Publishing (Firm)
Published in Nature structural & molecular biology

Journal Article

Exon-intron circular RNAs regulate transcription in the nucleus

by Li, Zhaoyong Huang, Chuan Bao, Chun Chen, Liang Lin, Mei Wang, Xiaolin Zhong, Guolin Yu, Bin Hu, Wanchen Dai, Limin Zhu, Pengfei Chang, Zhaoxia Wu, Qingfa Zhao, Yi Jia, Ya Xu, Ping Liu, Huijie Shan, Ge Published in Nature structural & molecular biology (01.03.2015)

“...Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of...”

Journal Article

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

by Tuttle, Marcus D Comellas, Gemma Nieuwkoop, Andrew J Covell, Dustin J Berthold, Deborah A Kloepper, Kathryn D Courtney, Joseph M Kim, Jae K Barclay, Alexander M Kendall, Amy Wan, William Stubbs, Gerald Schwieters, Charles D Lee, Virginia M Y George, Julia M Rienstra, Chad M Published in Nature structural & molecular biology (01.05.2016)

“...Misfolded α-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson's disease (PD). We present a...”

Journal Article

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

by Xiao, Yiling Ma, Buyong McElheny, Dan Parthasarathy, Sudhakar Long, Fei Hoshi, Minako Nussinov, Ruth Ishii, Yoshitaka Published in Nature structural & molecular biology (01.06.2015)

“...Increasing evidence has suggested that formation and propagation of misfolded aggregates of 42-residue human amyloid β (Aβ(1-42)), rather than of the more...”

Journal Article

Structural basis for human coronavirus attachment to sialic acid receptors

by Alejana Tortorici, M Walls, Alexana C Lang, Yifei Wang, Chunyan Li, Zeshi Koerhuis, Danielle Boons, Geert-Jan Bosch, Berend-Jan Rey, Félix A de Groot, Raoul J Veesler, David Published in Nature structural & molecular biology (01.06.2019)

“...Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S)...”

Journal Article

Structure and dynamics of GPCR signaling complexes

by Hilger, Daniel Masureel, Matthieu Kobilka, Brian K Published in Nature structural & molecular biology (01.01.2018)

“...G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering intracellular signaling through coupling with G proteins and arrestins...”

Journal Article

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

by Yan, Liying Yang, Mingyu Guo, Hongshan Yang, Lu Wu, Jun Li, Rong Liu, Ping Lian, Ying Zheng, Xiaoying Yan, Jie Huang, Jin Li, Ming Wu, Xinglong Wen, Lu Lao, Kaiqin Li, Ruiqiang Qiao, Jie Tang, Fuchou Published in Nature structural & molecular biology (01.09.2013)

“...Measuring gene expression in individual cells is crucial for understanding the gene regulatory network controlling human embryonic development. Here we apply...”

Journal Article

Mechanistic diversity in ATP-binding cassette (ABC) transporters

by Locher, Kaspar P Published in Nature structural & molecular biology (07.06.2016)

“...ABC transporters catalyze transport reactions, such as the high-affinity uptake of micronutrients into bacteria and the export of cytotoxic compounds from...”

Journal Article

Structure and function of long noncoding RNAs in epigenetic regulation

by Mercer, Tim R Mattick, John S Published in Nature structural & molecular biology (01.03.2013)

“...Genomes of complex organisms encode an abundance and diversity of long noncoding RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide...”

Journal Article

Determinants of nucleosome positioning

by Struhl, Kevin Segal, Eran Published in Nature structural & molecular biology (01.03.2013)

“...Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have...”

Journal Article

RNA polymerase II clustering through carboxy-terminal domain phase separation

by Boehning, Marc Dugast-Darzacq, Claire Rankovic, Marija Hansen, Anders S Yu, Taekyung Marie-Nelly, Herve McSwiggen, David T Kokic, Goran Dailey, Gina M Cramer, Patrick Darzacq, Xavier Zweckstetter, Markus Published in Nature structural & molecular biology (01.09.2018)

“...The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered low-complexity region that is critical for pre-mRNA transcription...”

Journal Article

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

by Jin, Zhenming Zhao, Yao Sun, Yuan Zhang, Bing Wang, Haofeng Wu, Yan Zhu, Yan Zhu, Chen Hu, Tianyu Du, Xiaoyu Duan, Yinkai Yu, Jing Yang, Xiaobao Yang, Xiuna Yang, Kailin Liu, Xiang Guddat, Luke W Xiao, Gengfu Zhang, Leike Yang, Haitao Rao, Zihe Published in Nature structural & molecular biology (01.06.2020)

“...The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (M ). Here, the X-ray crystal structure of M in complex with carmofur reveals...”

Journal Article

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

by Cohen, Samuel I A Arosio, Paolo Presto, Jenny Kurudenkandy, Firoz Roshan Biverstal, Henrik Dolfe, Lisa Dunning, Christopher Yang, Xiaoting Frohm, Birgitta Vendruscolo, Michele Johansson, Jan Dobson, Christopher M Fisahn, André Knowles, Tuomas P J Linse, Sara Published in Nature structural & molecular biology (01.03.2015)

“...Alzheimer's disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide...”

Journal Article

Transcriptional regulation by Polycomb group proteins

by Di Croce, Luciano Helin, Kristian Published in Nature structural & molecular biology (01.10.2013)

“...Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease...”

Journal Article

Discovery and annotation of long noncoding RNAs

by Mattick, John S Rinn, John L Published in Nature structural & molecular biology (01.01.2015)

“...Recent advances in RNA-sequencing technologies have led to the discovery of thousands of previously unannotated noncoding transcripts, including many long...”

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