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6by Li, Zhaoyong Huang, Chuan Bao, Chun Chen, Liang Lin, Mei Wang, Xiaolin Zhong, Guolin Yu, Bin Hu, Wanchen Dai, Limin Zhu, Pengfei Chang, Zhaoxia Wu, Qingfa Zhao, Yi Jia, Ya Xu, Ping Liu, Huijie Shan, Ge Published in Nature structural & molecular biology (01.03.2015)“...Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of...”
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7by Tuttle, Marcus D Comellas, Gemma Nieuwkoop, Andrew J Covell, Dustin J Berthold, Deborah A Kloepper, Kathryn D Courtney, Joseph M Kim, Jae K Barclay, Alexander M Kendall, Amy Wan, William Stubbs, Gerald Schwieters, Charles D Lee, Virginia M Y George, Julia M Rienstra, Chad M Published in Nature structural & molecular biology (01.05.2016)“...Misfolded α-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson's disease (PD). We present a...”
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8by Xiao, Yiling Ma, Buyong McElheny, Dan Parthasarathy, Sudhakar Long, Fei Hoshi, Minako Nussinov, Ruth Ishii, Yoshitaka Published in Nature structural & molecular biology (01.06.2015)“...Increasing evidence has suggested that formation and propagation of misfolded aggregates of 42-residue human amyloid β (Aβ(1-42)), rather than of the more...”
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9by Hilger, Daniel Masureel, Matthieu Kobilka, Brian K Published in Nature structural & molecular biology (01.01.2018)“...G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering intracellular signaling through coupling with G proteins and arrestins...”
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10by Yan, Liying Yang, Mingyu Guo, Hongshan Yang, Lu Wu, Jun Li, Rong Liu, Ping Lian, Ying Zheng, Xiaoying Yan, Jie Huang, Jin Li, Ming Wu, Xinglong Wen, Lu Lao, Kaiqin Li, Ruiqiang Qiao, Jie Tang, Fuchou Published in Nature structural & molecular biology (01.09.2013)“...Measuring gene expression in individual cells is crucial for understanding the gene regulatory network controlling human embryonic development. Here we apply...”
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11by Locher, Kaspar P Published in Nature structural & molecular biology (07.06.2016)“...ABC transporters catalyze transport reactions, such as the high-affinity uptake of micronutrients into bacteria and the export of cytotoxic compounds from...”
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12“...Genomes of complex organisms encode an abundance and diversity of long noncoding RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide...”
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13by Di Croce, Luciano Helin, Kristian Published in Nature structural & molecular biology (01.10.2013)“...Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease...”
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14“...Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have...”
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15“...Recent advances in RNA-sequencing technologies have led to the discovery of thousands of previously unannotated noncoding transcripts, including many long...”
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16by Zentner, Gabriel E Henikoff, Steven Published in Nature structural & molecular biology (01.03.2013)“...Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which...”
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17by Edupuganti, Raghu R Geiger, Simon Lindeboom, Rik G H Shi, Hailing Hsu, Phillip J Lu, Zhike Wang, Shuang-Yin Baltissen, Marijke P A Jansen, Pascal W T C Rossa, Martin Müller, Markus Stunnenberg, Hendrik G He, Chuan Carell, Thomas Vermeulen, Michiel Published in Nature structural & molecular biology (01.10.2017)“...RNA modifications are integral to the regulation of RNA metabolism. One abundant mRNA modification is N -methyladenosine (m A), which affects various aspects...”
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18by Chamberlain, Philip P Lopez-Girona, Antonia Miller, Karen Carmel, Gilles Pagarigan, Barbra Chie-Leon, Barbara Rychak, Emily Corral, Laura G Ren, Yan J Wang, Maria Riley, Mariko Delker, Silvia L Ito, Takumi Ando, Hideki Mori, Tomoyuki Hirano, Yoshinori Handa, Hiroshi Hakoshima, Toshio Daniel, Thomas O Cathers, Brian E Published in Nature structural & molecular biology (01.09.2014)“...The Cul4-Rbx1-DDB1-Cereblon E3 ubiquitin ligase complex is the target of thalidomide, lenalidomide and pomalidomide, therapeutically important drugs for...”
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19by Boehning, Marc Dugast-Darzacq, Claire Rankovic, Marija Hansen, Anders S Yu, Taekyung Marie-Nelly, Herve McSwiggen, David T Kokic, Goran Dailey, Gina M Cramer, Patrick Darzacq, Xavier Zweckstetter, Markus Published in Nature structural & molecular biology (01.09.2018)“...The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered low-complexity region that is critical for pre-mRNA transcription...”
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20by Alejana Tortorici, M Walls, Alexana C Lang, Yifei Wang, Chunyan Li, Zeshi Koerhuis, Danielle Boons, Geert-Jan Bosch, Berend-Jan Rey, Félix A de Groot, Raoul J Veesler, David Published in Nature structural & molecular biology (01.06.2019)“...Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S)...”