Search Results - "Nevado-Holgado, Alejo J"

Journal Article

Conditions for the Generation of Beta Oscillations in the Subthalamic Nucleus-Globus Pallidus Network

by Holgado, Alejo J Nevado Terry, John R Bogacz, Rafal Published in The Journal of neuroscience (15.09.2010)

“...The advance of Parkinson's disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13-30...”

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Journal Article

Effective connectivity of the subthalamic nucleus–globus pallidus network during Parkinsonian oscillations

by Nevado‐Holgado, Alejo J Mallet, Nicolas Magill, Peter J Bogacz, Rafal Published in The Journal of physiology (01.04.2014)

“...Key points The firing of subthalamic nucleus (STN) neurons and two types of external globus pallidus (GP) neuron becomes excessively and rhythmically...”

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Journal Article

Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease

by Winchester, Laura M Powell, John Lovestone, Simon Nevado-Holgado, Alejo J Published in Genome medicine (28.06.2018)

“...Studies have shown that low haemoglobin and anaemia are associated with poor cognition, and anaemia is known to be associated with Alzheimer's disease (AD),...”

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Journal Article

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

by Westwood, Sarah Liu, Benjamine Baird, Alison L Anand, Sneha Nevado-Holgado, Alejo J Newby, Danielle Pikkarainen, Maria Hallikainen, Merja Kuusisto, Johanna Streffer, Johannes R Novak, Gerald Blennow, Kaj Andreasson, Ulf Zetterberg, Henrik Smith, Ulf Laakso, Markku Soininen, Hilkka Lovestone, Simon Published in Alzheimer's research & therapy (26.04.2017)

“...Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer's disease (AD), although the relationship between IR and...”

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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

by Rojo, Ana I Pajares, Marta Rada, Patricia Nuñez, Angel Nevado-Holgado, Alejo J Killik, Richard Van Leuven, Fred Ribe, Elena Lovestone, Simon Yamamoto, Masayuki Cuadrado, Antonio Published in Redox biology (01.10.2017)

“...Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy...”

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Journal Article

Characterising the dynamics of EEG waveforms as the path through parameter space of a neural mass model: Application to epilepsy seizure evolution

by Nevado-Holgado, Alejo J Marten, Frank Richardson, Mark P Terry, John R Published in NeuroImage (Orlando, Fla.) (01.02.2012)

“...In this paper we propose that the dynamic evolution of EEG activity during epileptic seizures may be characterised as a path through parameter space of a...”

Journal Article

EXPLORING THE RELATIONSHIP BETWEEN ANAEMIA AND ALZHEIMER’S DISEASE

by Winchester, Laura Nevado-Holgado, Alejo J Lovestone, Simon Published in Alzheimer's & dementia (01.07.2017)

Journal Article

Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank

by Cullen, Breda Newby, Danielle Lee, Duncan Lyall, Donald M Nevado-Holgado, Alejo J Evans, Jonathan J Pell, Jill P Lovestone, Simon Cavanagh, Jonathan Published in Scientific reports (14.08.2018)

“...Observational studies have shown consistently increased likelihood of dementia or mild cognitive impairment diagnoses in people with higher air pollution...”

Journal Article

A PARKINSON’S DISEASE PROTEIN BIOMARKER PANEL USING THE SOMAMER ASSAY AND MACHINE LEARNING

by Barber, Imelda S Nevado-Holgado, Alejo J Lovestone, Simon Published in Alzheimer's & dementia (01.07.2017)

Journal Article

Commonly prescribed drugs associate with cognitive function: a cross-sectional study in UK Biobank

by Nevado-Holgado, Alejo J Kim, Chi-Hun Winchester, Laura Gallacher, John Lovestone, Simon Published in BMJ open (01.11.2016)

“...ObjectiveTo investigate medications associated with cognitive function.DesignPopulation-based cross-sectional cohort study.SettingUK Biobank.ParticipantsUK...”

Journal Article

Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach

by Nevado-Holgado, Alejo J Lovestone, Simon Published in Computational and structural biotechnology journal (2017)

“...Alzheimer's disease (AD) represents a substantial unmet need, due to increasing prevalence in an ageing society and the absence of a disease modifying therapy...”

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Journal Article

NOMINATION OF JAK-STAT SIGNALLING AS A TARGET FOR AD THERAPY THROUGH CLINICAL AND MOLECULAR INFORMATICS

by Nevado-Holgado, Alejo J Ribe, Elena M Kim, Chi-Hun Furlong, Laura Mayer, Miguel-Angel Lovestone, Simon Published in Alzheimer's & dementia (01.07.2017)

Journal Article

LEVELS OF BLOOD PRESSURE, BODY MASS INDEX AND TOTAL SERUM CHOLESTEROL AT DIFFERENT TIME POINTS PRIOR TO DEMENTIA DIAGNOSIS: A CASE CONTROL STUDY OF OVER 28 MILLION ELECTRONIC HEALT...

by Perera, Gayan Gungabissoon, Usha Alexander, Myriam Ansel, David Avillach, Paul Salles, Talita Duarte Gordon, Mark Forrest Nevado-Holgado, Alejo J Novak, Gerald P Pasqua, Alessandro Pedersen, Lars Ponjoan, Anna Rijnbeek, Peter Van Der Lei, Johan Stewart, Robert Published in Alzheimer's & dementia (01.07.2017)

Journal Article

A MASS SPECTROMETRY-BASED DISCOVERY AND REPLICATION OF A MULTI-ANALYTE CLASSIFIER FOR NEOCORTICAL AMYLOID PATHOLOGY

by Ashton, Nicholas J Nevado-Holgado, Alejo J Lynham, Steven Ward, Malcolm Gupta, Veer Bala Chatterjee, Pratishtha Gooze, Kathryn Hone, Eugene Pedrini, Steve Bush, Ashley I Rowe, Christopher C Villemagne, Victor L.L Ames, David Masters, Colin L Aarsland, Dag Lovestone, Simon Martins, Ralph N Hye, Abdul Published in Alzheimer's & dementia (01.07.2017)

Journal Article

Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study

by Newby, Danielle Prieto-Alhambra, Daniel Duarte-Salles, Talita Ansell, David Pedersen, Lars van der Lei, Johan Mosseveld, Mees Rijnbeek, Peter James, Glen Alexander, Myriam Egger, Peter Podhorna, Jana Stewart, Robert Perera, Gayan Avillach, Paul Grosdidier, Solène Lovestone, Simon Nevado-Holgado, Alejo J Published in Alzheimer's research & therapy (06.04.2020)

“...Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and...”

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Journal Article

Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result

by Westwood, Sarah Baird, Alison L Hye, Abdul Ashton, Nicholas J Nevado-Holgado, Alejo J Anand, Sneha N Liu, Benjamine Newby, Danielle Bazenet, Chantal Kiddle, Steven J Ward, Malcolm Newton, Ben Desai, Keyur Tan Hehir, Cristina Zanette, Michelle Galimberti, Daniela Parnetti, Lucilla Lleó, Alberto Baker, Susan Narayan, Vaibhav A van der Flier, Wiesje M Scheltens, Philip Teunissen, Charlotte E Visser, Pieter Jelle Lovestone, Simon Published in Frontiers in aging neuroscience (2018)

“...Background: Blood biomarkers may aid in recruitment to clinical trials of Alzheimer's disease (AD) modifying therapeutics by triaging potential trials...”

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Journal Article

Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer's Disease Therapeutic Development

by Nevado-Holgado, Alejo J Ribe, Elena Thei, Laura Furlong, Laura Mayer, Miguel-Angel Quan, Jie Richardson, Jill C Cavanagh, Jonathan Consortium, Nima Lovestone, Simon Published in Cells (Basel, Switzerland) (08.05.2019)

“...As genome-wide association studies (GWAS) have grown in size, the number of genetic variants that have been associated per disease has correspondingly...”

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Mental disorders and intimate partner violence perpetrated by men towards women: A Swedish population-based longitudinal study

by Yu, Rongqin Nevado-Holgado, Alejo J Molero, Yasmina D'Onofrio, Brian M Larsson, Henrik Howard, Louise M Fazel, Seena Moyer, Caitlin
edited by Hay, Phillipa J
Published in PLoS medicine (17.12.2019)

“...Using Swedish nationwide registries, we identified men from 9 diagnostic groups over 1998-2013, with sample sizes ranging from 9,529 with autism to 88,182 with...”

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Oscillatory Activity in the Medial Prefrontal Cortex and Nucleus Accumbens Correlates with Impulsivity and Reward Outcome

by Donnelly, Nicholas A Holtzman, Tahl Rich, P Dylan Nevado-Holgado, Alejo J Fernando, Anushka B P Van Dijck, Gert Holzhammer, Tobias Paul, Oliver Ruther, Patrick Paulsen, Ole Robbins, Trevor W Dalley, Jeffrey W
edited by Tort, Adriano B. L
Published in PloS one (2014-00-00)

“...Actions expressed prematurely without regard for their consequences are considered impulsive. Such behaviour is governed by a network of brain regions...”

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Journal Article

Comparing multiple clustering approaches to understand proteomic datasets for improved biomarker detection

by Winchester, Laura Shi, Liu Kormilitzin, Andrey Nevado‐Holgado, Alejo J Published in Alzheimer's & dementia (01.12.2020)

“...Background Development of reproducible blood‐based protein biomarker for Alzheimer’s Disease would allow clinicians and researchers to diagnose and potentially...”

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