Search Results - "PLoS genetics"

Journal Article

Cell-type specific features of circular RNA expression

by Salzman, Julia Chen, Raymond E Olsen, Mari N Wang, Peter L Brown, Patrick O
edited by Moran, John V
Published in PLoS genetics (2013-00-00)

“...Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using...”

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Journal Article

Genetic compensation: a phenomenon in search of mechanisms

by El-Brolosy, Mohamed A Stainier, Didier Y R
edited by Moens, Cecilia
Published in PLoS genetics (01.07.2017)

“...Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e.,...”

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Journal Article

A genomic overview of the population structure of Salmonella

by Alikhan, Nabil-Fareed Zhou, Zhemin Sergeant, Martin J Achtman, Mark
edited by Casadesús, Josep
Published in PLoS genetics (01.04.2018)

“...For many decades, Salmonella enterica has been subdivided by serological properties into serovars or further subdivided for epidemiological tracing by a...”

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Journal Article

Power and Predictive Accuracy of Polygenic Risk Scores

by Dudbridge, Frank
edited by Wray, Naomi R
Published in PLoS genetics (01.03.2013)

“...Polygenic scores have recently been used to summarise genetic effects among an ensemble of markers that do not individually achieve significance in a...”

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Journal Article

Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data

by Pickrell, Joseph K Pritchard, Jonathan K
edited by Tang, Hua
Published in PLoS genetics (01.11.2012)

“...PLoS Genet 8(11): e1002967 (2012) Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these...”

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Journal Article

Robust Demographic Inference from Genomic and SNP Data

by Excoffier, Laurent Dupanloup, Isabelle Huerta-Sánchez, Emilia Sousa, Vitor C Foll, Matthieu
edited by Akey, Joshua M
Published in PLoS genetics (01.10.2013)

“...We introduce a flexible and robust simulation-based framework to infer demographic parameters from the site frequency spectrum (SFS) computed on large genomic...”

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Journal Article

Genic intolerance to functional variation and the interpretation of personal genomes

by Petrovski, Slave Wang, Quanli Heinzen, Erin L Allen, Andrew S Goldstein, David B
edited by Williams, Scott M
Published in PLoS genetics (01.08.2013)

“...A central challenge in interpreting personal genomes is determining which mutations most likely influence disease. Although progress has been made in scoring...”

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Journal Article

Detecting Individual Sites Subject to Episodic Diversifying Selection

by Murrell, Ben Wertheim, Joel O Moola, Sasha Weighill, Thomas Scheffler, Konrad Kosakovsky Pond, Sergei L
edited by Malik, Harmit S
Published in PLoS genetics (2012-00-00)

“...The imprint of natural selection on protein coding genes is often difficult to identify because selection is frequently transient or episodic, i.e. it affects...”

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Journal Article

Iterative usage of fixed and random effect models for powerful and efficient genome‐wide association studies

by Liu, Xiaolei Huang, Meng Fan, Bin Buckler, Edward S Zhang, Zhiwu
edited by Listgarten, Jennifer
Published in PLoS genetics (01.02.2016)

“...False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed effect and random effect Mixed Linear Model (MLM) that...”

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Journal Article

Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs

by Hangauer, Matthew J Vaughn, Ian W McManus, Michael T
edited by Rinn, John L
Published in PLoS genetics (01.06.2013)

“...Known protein coding gene exons compose less than 3% of the human genome. The remaining 97% is largely uncharted territory, with only a small fraction...”

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Journal Article

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments

by Leblond, Claire S Nava, Caroline Polge, Anne Gauthier, Julie Huguet, Guillaume Lumbroso, Serge Giuliano, Fabienne Stordeur, Coline Depienne, Christel Mouzat, Kevin Pinto, Dalila Howe, Jennifer Lemière, Nathalie Durand, Christelle M Guibert, Jessica Ey, Elodie Toro, Roberto Peyre, Hugo Mathieu, Alexandre Amsellem, Frédérique Rastam, Maria Gillberg, I Carina Rappold, Gudrun A Holt, Richard Monaco, Anthony P Maestrini, Elena Galan, Pilar Heron, Delphine Jacquette, Aurélia Afenjar, Alexandra Rastetter, Agnès Brice, Alexis Devillard, Françoise Assouline, Brigitte Laffargue, Fanny Lespinasse, James Chiesa, Jean Rivier, François Bonneau, Dominique Regnault, Beatrice Zelenika, Diana Delepine, Marc Lathrop, Mark Sanlaville, Damien Schluth-Bolard, Caroline Edery, Patrick Perrin, Laurence Tabet, Anne Claude Schmeisser, Michael J Boeckers, Tobias M Coleman, Mary Sato, Daisuke Szatmari, Peter Scherer, Stephen W Rouleau, Guy A Betancur, Catalina Leboyer, Marion Gillberg, Christopher Delorme, Richard Bourgeron, Thomas
edited by Barsh, Gregory S
Published in PLoS genetics (01.09.2014)

“...SHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on...”

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