Search Results - "Rass, Ulrich"

Journal Article

by Rass, Ulrich Published in Nature chemical biology (01.03.2019)

“...Holliday junction resolvases lock dynamic DNA four-way junctions into specific structural conformations for symmetric DNA cleavage. Single-molecule studies now...”

Journal Article

Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes

by Rass, Ulrich Published in Chromosoma (01.12.2013)

“...Genome duplication requires that replication forks track the entire length of every chromosome. When complications occur, homologous recombination-mediated...”

Fulltext

Journal Article

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue

by Appanah, Rowin Jones, David Falquet, Benoît Rass, Ulrich Published in Current genetics (09.09.2020)

“...Abstract The disease-associated nuclease–helicase DNA2 has been implicated in DNA end-resection during DNA double-strand break repair, Okazaki fragment...”

Journal Article

Identification of Holliday junction resolvases from humans and yeast

by IP, Stephen C. Y RASS, Ulrich BLANCO, Miguel G FLYNN, Helen R SKEHEL, J. Mark WEST, Stephen C Published in Nature (London) (2008)

“...Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for...”

Journal Article

Structure-Specific Endonucleases and the Resolution of Chromosome Underreplication

by Falquet, Benoît Rass, Ulrich Published in Genes (19.03.2019)

“...Complete genome duplication in every cell cycle is fundamental for genome stability and cell survival. However, chromosome replication is frequently challenged...”

Fulltext

Journal Article

Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

by Ölmezer, Gizem Levikova, Maryna Klein, Dominique Falquet, Benoît Fontana, Gabriele Alessandro Cejka, Petr Rass, Ulrich Published in Nature communications (25.10.2016)

“...Cells have evolved mechanisms to protect, restart and repair perturbed replication forks, allowing full genome duplication, even under replication stress...”

Journal Article

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

by Caldecott, Keith W El-Khamisy, Sherif F Katyal, Sachin McKinnon, Peter J Clements, Paula M Rass, Ulrich West, Stephen C Ahel, Ivan Published in Nature (12.10.2006)

“...Ataxia oculomotor apraxia-1 (AOA1) is a neurological disorder caused by mutations in the gene (APTX) encoding aprataxin. Aprataxin is a member of the histidine...”

Fulltext

Journal Article

Actions of Aprataxin in Multiple DNA Repair Pathways

by Rass, Ulrich Ahel, Ivan West, Stephen C Published in The Journal of biological chemistry (30.03.2007)

“...Mutations in the Aptx gene lead to a neurological disorder known as ataxia oculomotor apraxia-1. The product of Aptx is Aprataxin (Aptx), a DNA-binding protein...”

Fulltext

Journal Article

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

by Fontana, Gabriele A Hess, Daniel Reinert, Julia K Mattarocci, Stefano Falquet, Benoît Klein, Dominique Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature communications (10.06.2019)

“...Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular...”

Journal Article

Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

by Mattarocci, Stefano Reinert, Julia K Bunker, Richard D Fontana, Gabriele A Shi, Tianlai Klein, Dominique Cavadini, Simone Faty, Mahamadou Shyian, Maksym Hafner, Lukas Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature structural & molecular biology (01.07.2017)

“...In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chromosome ends. In mammalian cells, Rif1 is not telomeric,...”

Journal Article

Molecular Mechanism of DNA Deadenylation by the Neurological Disease Protein Aprataxin

by Ulrich Rass Ivan Ahel Stephen C. West Published in The Journal of biological chemistry (05.12.2008)

“...The human neurological disease known as ataxia with oculomotor apraxia 1 is caused by mutations in the APTX gene that encodes Aprataxin (APTX) protein. APTX is...”

Fulltext

Journal Article

A new role for Holliday junction resolvase Yen1 in processing DNA replication intermediates exposes Dna2 as an accessory replicative helicase

by Falquet, Benoît Rass, Ulrich Published in Microbial cell (02.01.2017)

“...DNA replication is mediated by a multi-protein complex known as the replisome. With the hexameric MCM (minichromosome maintenance) replicative helicase at its...”

Fulltext

Journal Article

Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks

by Fontana, Gabriele A Reinert, Julia K Thomä, Nicolas H Rass, Ulrich Published in Microbial cell (17.05.2018)

“...Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs)...”

Fulltext

eBook

Die Sozialauswahl bei betriebsbedingter Kündigung: Ein Versuch der Entwicklung datenverarbeitungsgeeigneter Kriterien im Spannungsfeld zwischen Datenschutz, Rechtssicherheit und so...

by Rass, Ulrich P
2020

Dissertation

Die Sozialauswahl bei betriebsbedingter Kündigung: e. Versuch d. Entwicklung datenverarbeitungsgeeigneter Kriterien im Spannungsfeld zwischen Datenschutz, Rechtssicherheit u. sozia...

by Rass, Ulrich Ph
1986

Holdings Uni Bonn

Journal Article

Defective DNA Repair and Neurodegenerative Disease

by Rass, Ulrich Ahel, Ivan West, Stephen C Published in Cell (Cambridge) (2007)

“...Defects in cellular DNA repair processes have been linked to genome instability, heritable cancers, and premature aging syndromes. Yet defects in some repair...”

Fulltext

Book

Die Sozialauswahl bei betriebsbedingter Kündigung: e. Versuch d. Entwicklung datenverarbeitungsgeeigneter Kriterien im Spannungsfeld zwischen Datenschutz, Rechtssicherheit u. sozia...

by Rass, Ulrich P
1986

Journal Article

Disease-associated DNA2 nuclease–helicase protects cells from lethal chromosome under-replication

by Falquet, Benoît Ölmezer, Gizem Enkner, Franz Klein, Dominique Challa, Kiran Appanah, Rowin Gasser, Susan M Rass, Ulrich Published in Nucleic acids research (27.07.2020)

“...Abstract DNA2 is an essential nuclease–helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalled DNA replication forks...”

Fulltext

Journal Article

DNA repair defects ascribed to pby1 are caused by disruption of Holliday junction resolvase Mus81-Mms4

by Ölmezer, Gizem Klein, Dominique Rass, Ulrich Published in DNA repair (01.09.2015)

“...PBY1 continues to be linked with DNA repair through functional genomics studies in yeast. Using the yeast knockout (YKO) strain collection, high-throughput...”

Journal Article

Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

by Ölmezer, Gizem Levikova, Maryna Klein, Dominique Falquet, Benoît Fontana, Gabriele Alessandro Cejka, Petr Rass, Ulrich
25.10.2016

“...Cells have evolved mechanisms to protect, restart and repair perturbed replication forks, allowing full genome duplication, even under replication stress...”

Fulltext

Narrow search