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  • Your search results: "Roselle Gélinas"
Showing 1 - 20 results of 51 for search '"Roselle Gélinas"', query time: 1.83s Narrow search
  • 1
    Cover Image Journal Article
    AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
    by Gélinas, Roselle   Mailleux, Florence   Dontaine, Justine   Bultot, Laurent   Demeulder, Bénédicte   Ginion, Audrey   Daskalopoulos, Evangelos P   Esfahani, Hrag   Dubois-Deruy, Emilie   Lauzier, Benjamin   Gauthier, Chantal   Olson, Aaron K   Bouchard, Bertrand   Des Rosiers, Christine   Viollet, Benoit   Sakamoto, Kei   Balligand, Jean-Luc   Vanoverschelde, Jean-Louis   Beauloye, Christophe   Horman, Sandrine   Bertrand, Luc Published in Nature communications (25.01.2018)
    “...AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte...”
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  • 2
    Cover Image Journal Article
    O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?
    by Mailleux, Florence   Gélinas, Roselle   Beauloye, Christophe   Horman, Sandrine   Bertrand, Luc Published in Biochimica et biophysica acta. Molecular basis of disease (01.12.2016)
    “...O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine...”
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  • 3
    Cover Image Journal Article
    Molecular Autopsy Implicates Primary Carnitine Deficiency in Sudden Unexplained Death and Reversible Short QT Syndrome
    by Gélinas, Roselle   Leach, Emma   Horvath, Gabriella   Laksman, Zachary Published in Canadian journal of cardiology (01.09.2019)
    “...We report a case of sudden unexplained death in a young asymptomatic woman in whom postmortem genetic testing after a negative autopsy identified a homozygous...”
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  • 4
    Cover Image Journal Article
    AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes
    by Gélinas, Roselle   Dontaine, Justine   Horman, Sandrine   Beauloye, Christophe   Bultot, Laurent   Bertrand, Luc Published in Frontiers in endocrinology (Lausanne) (2018-00-00)
    “...The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. Its activation under energetic stress is known to activate energy-producing...”
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  • 5
    Cover Image Journal Article
    TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT
    by Devalla, Harsha D   Gélinas, Roselle   Aburawi, Elhadi H   Beqqali, Abdelaziz   Goyette, Philippe   Freund, Christian   Chaix, Marie-A   Taos, Rafik   Jiang, Hui   Le Béchec, Antony   Monshouwer-Kloots, Jantine J   Zwetsloot, Tom   Kosmidis, Georgios   Latour, Frédéric   Alikashani, Azadeh   Hoekstra, Maaike   Schlaepfer, Jurg   Mummery, Christine L   Stevenson, Brian   Kutalik, Zoltan   de Vries, Antoine Af   Rivard, Léna   Wilde, Arthur Am   Talajic, Mario   Verkerk, Arie O   Al-Gazali, Lihadh   Rioux, John D   Bhuiyan, Zahurul A   Passier, Robert Published in EMBO molecular medicine (2016)
    “...Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole-exome sequencing (WES) was carried out on patients from three...”
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  • 6
    Cover Image Journal Article
    Metabolic Tracing Using Stable Isotope-Labeled Substrates and Mass Spectrometry in the Perfused Mouse Heart
    by Ruiz, Matthieu   Gélinas, Roselle   Vaillant, Fanny   Lauzier, Benjamin   Des Rosiers, Christine Published in Methods in enzymology (2015-00-00)
    “...There has been a resurgence of interest for the field of cardiac metabolism catalyzed by evidence demonstrating a role of metabolic dysregulation in the...”
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  • 7
    Cover Image Journal Article
    Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts
    by Roselle Gélinas   Julie Thompson-Legault   Bertrand Bouchard   Caroline Daneault   Asmaa Mansour   Marc-Antoine Gillis   Guy Charron   Victor Gavino   François Labarthe   Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.09.2011)
    “...Patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency frequently present cardiomyopathy and heartbeat disorders. However, the underlying...”
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  • 8
    Cover Image Journal Article
    Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake
    by Renguet, Edith   Ginion, Audrey   Gélinas, Roselle   Bultot, Laurent   Auquier, Julien   Robillard Frayne, Isabelle   Daneault, Caroline   Vanoverschelde, Jean-Louis   Des Rosiers, Christine   Hue, Louis   Horman, Sandrine   Beauloye, Christophe   Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (01.08.2017)
    “...High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose...”
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  • 9
    Cover Image Journal Article
    A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake
    by Timmermans, Aurélie D   Balteau, Magali   Gélinas, Roselle   Renguet, Edith   Ginion, Audrey   de Meester, Carole   Sakamoto, Kei   Balligand, Jean-Luc   Bontemps, Françoise   Vanoverschelde, Jean-Louis   Horman, Sandrine   Beauloye, Christophe   Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (15.06.2014)
    “...AMP-activated protein kinase (AMPK), a key cellular sensor of energy, regulates metabolic homeostasis and plays a protective role in the ischemic or diabetic...”
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  • 10
    Cover Image Journal Article
    Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway
    by Lauzier, Benjamin   Vaillant, Fanny   Merlen, Clemence   Gélinas, Roselle   Bouchard, Bertrand   Rivard, Marie-Eve   Labarthe, Francois   Dolinsky, Vern W   Dyck, Jason R.B   Allen, Bruce G   Chatham, John C   Des Rosiers, Christine Published in Journal of molecular and cellular cardiology (2012)
    “...Abstract Glutamine, the most abundant amino acid in plasma, has attracted considerable interest for its cardioprotective properties. The primary effect of...”
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  • 11
    Cover Image Journal Article
    Reduction in Na+ current by angiotensin II is mediated by PKCα in mouse and human-induced pluripotent stem cell–derived cardiomyocytes
    by Mathieu, Sophie, PhD   El Khoury, Nabil, MSc   Rivard, Katy, PhD   Gélinas, Roselle, PhD   Goyette, Philippe, PhD   Paradis, Pierre, PhD   Nemer, Mona, PhD   Fiset, Céline, PhD Published in Heart rhythm (2016)
    “...Background Ventricular arrhythmias and sudden cardiac deaths are among the leading causes of mortality in patients with heart failure, and the underlying...”
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  • 12
    Cover Image Journal Article
    Mouse strain differences in metabolic fluxes and function of ex vivo working hearts
    by Fanny Vaillant   Benjamin Lauzier   Isabelle Poirier   Roselle Gélinas   Marie-Eve Rivard   Isabelle Robillard Frayne   Eric Thorin   Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2014)
    “...In mice, genetic background is known to influence various parameters, including cardiac function. Its impact on cardiac energy substrate metabolism-a factor...”
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  • 13
    Cover Image Journal Article
    Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts
    by Benjamin Lauzier   Fanny Vaillant   Roselle Gélinas   Bertrand Bouchard   Roger Brownsey   Eric Thorin   Jean-Claude Tardif   Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.03.2011)
    “...Heart rate reduction (HRR) is an important target in the management of patients with chronic stable angina. Most available drugs for HRR, such as β-blockers,...”
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  • 14
    Cover Image Journal Article
    Medium-chain Fatty Acids as Metabolic Therapy in Cardiac Disease
    by Labarthe, François   Gélinas, Roselle   Des Rosiers, Christine Published in Cardiovascular drugs and therapy (01.04.2008)
    “...Medium-chain fatty acids (MCFAs) have physical and metabolic properties that are distinct from those of long-chain fatty acids, which make them a readily...”
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  • 15
    Cover Image Journal Article
    Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation
    by Khairallah, Ramzi J   Khairallah, Maya   Gélinas, Roselle   Bouchard, Bertrand   Young, Martin E   Allen, Bruce G   Lopaschuk, Gary D   Deschepper, Christian F   Des Rosiers, Christine Published in Journal of molecular and cellular cardiology (2008)
    “...Abstract While the balance between carbohydrates and fatty acids for energy production appears to be crucial for cardiac homeostasis, much remains to be...”
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  • 16
    Cover Image Journal Article
    Alterations in carbohydrate metabolism and its regulation in PPARα null mouse hearts
    by Roselle Gélinas   François Labarthe   Bertrand Bouchard   Janie Mc Duff   Guy Charron   Martin E. Young   Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.04.2008)
    “...Although a shift from fatty acids (FAs) to carbohydrates (CHOs) is considered beneficial for the diseased heart, it is unclear why subjects with FA β-oxidation...”
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  • 17
    Cover Image Journal Article
    Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats
    by Sébastien L. Ménard   Etienne Croteau   Otman Sarrhini   Roselle Gélinas   Pascal Brassard   René Ouellet   M'hamed Bentourkia   Johannes E. van Lier   Christine Des Rosiers   Roger Lecomte   André C. Carpentier Published in American Journal of Physiology - Endocrinology and Metabolism (01.05.2010)
    “...The purpose of this study was to determine in vivo myocardial energy metabolism and function in a nutritional model of type 2 diabetes. Wistar rats rendered...”
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  • 18
    Cover Image Journal Article
    Alterations in carbohydrate metabolism and its regulation in PPAR{alpha} null mouse hearts
    by Gelinas, Roselle   Labarthe, Francois   Bouchard, Bertrand   Mc Duff, Janie   Charron, Guy   Young, Martin E   Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.04.2008)
    “...1 Department of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Quebec, Canada; 2 Centre Hospitalier Régional et Universitaire de...”
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  • 19
    Cover Image Journal Article
    Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy
    by Dubois‐Deruy, Emilie   Gelinas, Roselle   Beauloye, Christophe   Esfahani, Hrag   Michel, Lauriane Y.M   Dessy, Chantal   Bertrand, Luc   Balligand, Jean‐Luc Published in ESC Heart Failure (01.06.2020)
    “...Aims The abundance of beta 3‐adrenergic receptors (β3‐ARs) is upregulated in diseased human myocardium. We previously showed that cardiac‐specific expression...”
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  • 20
    Cover Image Journal Article
    O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?
    by Mailleux, Florence   Gélinas, Roselle   Beauloye, Christophe   Horman, Sandrine   Bertrand, Luc Published in BBA - Molecular Basis of Disease (2016)
    “...O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine...”
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