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1by Gélinas, Roselle Mailleux, Florence Dontaine, Justine Bultot, Laurent Demeulder, Bénédicte Ginion, Audrey Daskalopoulos, Evangelos P Esfahani, Hrag Dubois-Deruy, Emilie Lauzier, Benjamin Gauthier, Chantal Olson, Aaron K Bouchard, Bertrand Des Rosiers, Christine Viollet, Benoit Sakamoto, Kei Balligand, Jean-Luc Vanoverschelde, Jean-Louis Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in Nature communications (25.01.2018)“...AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte...”
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2by Mailleux, Florence Gélinas, Roselle Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in Biochimica et biophysica acta. Molecular basis of disease (01.12.2016)“...O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine...”
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3by Gélinas, Roselle Leach, Emma Horvath, Gabriella Laksman, Zachary Published in Canadian journal of cardiology (01.09.2019)“...We report a case of sudden unexplained death in a young asymptomatic woman in whom postmortem genetic testing after a negative autopsy identified a homozygous...”
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4by Gélinas, Roselle Dontaine, Justine Horman, Sandrine Beauloye, Christophe Bultot, Laurent Bertrand, Luc Published in Frontiers in endocrinology (Lausanne) (2018-00-00)“...The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. Its activation under energetic stress is known to activate energy-producing...”
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5by Devalla, Harsha D Gélinas, Roselle Aburawi, Elhadi H Beqqali, Abdelaziz Goyette, Philippe Freund, Christian Chaix, Marie-A Taos, Rafik Jiang, Hui Le Béchec, Antony Monshouwer-Kloots, Jantine J Zwetsloot, Tom Kosmidis, Georgios Latour, Frédéric Alikashani, Azadeh Hoekstra, Maaike Schlaepfer, Jurg Mummery, Christine L Stevenson, Brian Kutalik, Zoltan de Vries, Antoine Af Rivard, Léna Wilde, Arthur Am Talajic, Mario Verkerk, Arie O Al-Gazali, Lihadh Rioux, John D Bhuiyan, Zahurul A Passier, Robert Published in EMBO molecular medicine (2016)“...Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole-exome sequencing (WES) was carried out on patients from three...”
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6by Ruiz, Matthieu Gélinas, Roselle Vaillant, Fanny Lauzier, Benjamin Des Rosiers, Christine Published in Methods in enzymology (2015-00-00)“...There has been a resurgence of interest for the field of cardiac metabolism catalyzed by evidence demonstrating a role of metabolic dysregulation in the...”
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7by Roselle Gélinas Julie Thompson-Legault Bertrand Bouchard Caroline Daneault Asmaa Mansour Marc-Antoine Gillis Guy Charron Victor Gavino François Labarthe Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.09.2011)“...Patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency frequently present cardiomyopathy and heartbeat disorders. However, the underlying...”
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8by Renguet, Edith Ginion, Audrey Gélinas, Roselle Bultot, Laurent Auquier, Julien Robillard Frayne, Isabelle Daneault, Caroline Vanoverschelde, Jean-Louis Des Rosiers, Christine Hue, Louis Horman, Sandrine Beauloye, Christophe Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (01.08.2017)“...High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose...”
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9by Timmermans, Aurélie D Balteau, Magali Gélinas, Roselle Renguet, Edith Ginion, Audrey de Meester, Carole Sakamoto, Kei Balligand, Jean-Luc Bontemps, Françoise Vanoverschelde, Jean-Louis Horman, Sandrine Beauloye, Christophe Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (15.06.2014)“...AMP-activated protein kinase (AMPK), a key cellular sensor of energy, regulates metabolic homeostasis and plays a protective role in the ischemic or diabetic...”
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10by Lauzier, Benjamin Vaillant, Fanny Merlen, Clemence Gélinas, Roselle Bouchard, Bertrand Rivard, Marie-Eve Labarthe, Francois Dolinsky, Vern W Dyck, Jason R.B Allen, Bruce G Chatham, John C Des Rosiers, Christine Published in Journal of molecular and cellular cardiology (2012)“...Abstract Glutamine, the most abundant amino acid in plasma, has attracted considerable interest for its cardioprotective properties. The primary effect of...”
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11by Mathieu, Sophie, PhD El Khoury, Nabil, MSc Rivard, Katy, PhD Gélinas, Roselle, PhD Goyette, Philippe, PhD Paradis, Pierre, PhD Nemer, Mona, PhD Fiset, Céline, PhD Published in Heart rhythm (2016)“...Background Ventricular arrhythmias and sudden cardiac deaths are among the leading causes of mortality in patients with heart failure, and the underlying...”
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12by Fanny Vaillant Benjamin Lauzier Isabelle Poirier Roselle Gélinas Marie-Eve Rivard Isabelle Robillard Frayne Eric Thorin Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2014)“...In mice, genetic background is known to influence various parameters, including cardiac function. Its impact on cardiac energy substrate metabolism-a factor...”
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13by Benjamin Lauzier Fanny Vaillant Roselle Gélinas Bertrand Bouchard Roger Brownsey Eric Thorin Jean-Claude Tardif Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.03.2011)“...Heart rate reduction (HRR) is an important target in the management of patients with chronic stable angina. Most available drugs for HRR, such as β-blockers,...”
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14by Labarthe, François Gélinas, Roselle Des Rosiers, Christine Published in Cardiovascular drugs and therapy (01.04.2008)“...Medium-chain fatty acids (MCFAs) have physical and metabolic properties that are distinct from those of long-chain fatty acids, which make them a readily...”
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15by Khairallah, Ramzi J Khairallah, Maya Gélinas, Roselle Bouchard, Bertrand Young, Martin E Allen, Bruce G Lopaschuk, Gary D Deschepper, Christian F Des Rosiers, Christine Published in Journal of molecular and cellular cardiology (2008)“...Abstract While the balance between carbohydrates and fatty acids for energy production appears to be crucial for cardiac homeostasis, much remains to be...”
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16by Roselle Gélinas François Labarthe Bertrand Bouchard Janie Mc Duff Guy Charron Martin E. Young Christine Des Rosiers Published in American Journal of Physiology - Heart and Circulatory Physiology (01.04.2008)“...Although a shift from fatty acids (FAs) to carbohydrates (CHOs) is considered beneficial for the diseased heart, it is unclear why subjects with FA β-oxidation...”
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17by Sébastien L. Ménard Etienne Croteau Otman Sarrhini Roselle Gélinas Pascal Brassard René Ouellet M'hamed Bentourkia Johannes E. van Lier Christine Des Rosiers Roger Lecomte André C. Carpentier Published in American Journal of Physiology - Endocrinology and Metabolism (01.05.2010)“...The purpose of this study was to determine in vivo myocardial energy metabolism and function in a nutritional model of type 2 diabetes. Wistar rats rendered...”
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18by Gelinas, Roselle Labarthe, Francois Bouchard, Bertrand Mc Duff, Janie Charron, Guy Young, Martin E Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.04.2008)“...1 Department of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Quebec, Canada; 2 Centre Hospitalier Régional et Universitaire de...”
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19by Dubois‐Deruy, Emilie Gelinas, Roselle Beauloye, Christophe Esfahani, Hrag Michel, Lauriane Y.M Dessy, Chantal Bertrand, Luc Balligand, Jean‐Luc Published in ESC Heart Failure (01.06.2020)“...Aims The abundance of beta 3‐adrenergic receptors (β3‐ARs) is upregulated in diseased human myocardium. We previously showed that cardiac‐specific expression...”
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20by Mailleux, Florence Gélinas, Roselle Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in BBA - Molecular Basis of Disease (2016)“...O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine...”