Search Results - "Roselle Gélinas"

Journal Article

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

by Gélinas, Roselle Mailleux, Florence Dontaine, Justine Bultot, Laurent Demeulder, Bénédicte Ginion, Audrey Daskalopoulos, Evangelos P Esfahani, Hrag Dubois-Deruy, Emilie Lauzier, Benjamin Gauthier, Chantal Olson, Aaron K Bouchard, Bertrand Des Rosiers, Christine Viollet, Benoit Sakamoto, Kei Balligand, Jean-Luc Vanoverschelde, Jean-Louis Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in Nature communications (25.01.2018)

“...AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte...”

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Journal Article

O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?

by Mailleux, Florence Gélinas, Roselle Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in Biochimica et biophysica acta. Molecular basis of disease (01.12.2016)

“...O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine...”

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Journal Article

Molecular Autopsy Implicates Primary Carnitine Deficiency in Sudden Unexplained Death and Reversible Short QT Syndrome

by Gélinas, Roselle Leach, Emma Horvath, Gabriella Laksman, Zachary Published in Canadian journal of cardiology (01.09.2019)

“...We report a case of sudden unexplained death in a young asymptomatic woman in whom postmortem genetic testing after a negative autopsy identified a homozygous...”

Journal Article

AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes

by Gélinas, Roselle Dontaine, Justine Horman, Sandrine Beauloye, Christophe Bultot, Laurent Bertrand, Luc Published in Frontiers in endocrinology (Lausanne) (2018-00-00)

“...The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. Its activation under energetic stress is known to activate energy-producing...”

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Journal Article

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

by Devalla, Harsha D Gélinas, Roselle Aburawi, Elhadi H Beqqali, Abdelaziz Goyette, Philippe Freund, Christian Chaix, Marie-A Taos, Rafik Jiang, Hui Le Béchec, Antony Monshouwer-Kloots, Jantine J Zwetsloot, Tom Kosmidis, Georgios Latour, Frédéric Alikashani, Azadeh Hoekstra, Maaike Schlaepfer, Jurg Mummery, Christine L Stevenson, Brian Kutalik, Zoltan de Vries, Antoine Af Rivard, Léna Wilde, Arthur Am Talajic, Mario Verkerk, Arie O Al-Gazali, Lihadh Rioux, John D Bhuiyan, Zahurul A Passier, Robert Published in EMBO molecular medicine (2016)

“...Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole-exome sequencing (WES) was carried out on patients from three...”

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Journal Article

Metabolic Tracing Using Stable Isotope-Labeled Substrates and Mass Spectrometry in the Perfused Mouse Heart

by Ruiz, Matthieu Gélinas, Roselle Vaillant, Fanny Lauzier, Benjamin Des Rosiers, Christine Published in Methods in enzymology (2015-00-00)

“...There has been a resurgence of interest for the field of cardiac metabolism catalyzed by evidence demonstrating a role of metabolic dysregulation in the...”

Journal Article

Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts

by Gélinas, Roselle Thompson-Legault, Julie Bouchard, Bertrand Daneault, Caroline Mansour, Asmaa Gillis, Marc-Antoine Charron, Guy Gavino, Victor Labarthe, François Des Rosiers, Christine Published in American Journal of Physiology - Heart and Circulatory Physiology (01.09.2011)

“...Patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency frequently present cardiomyopathy and heartbeat disorders. However, the underlying...”

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Journal Article

Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake

by Renguet, Edith Ginion, Audrey Gélinas, Roselle Bultot, Laurent Auquier, Julien Robillard Frayne, Isabelle Daneault, Caroline Vanoverschelde, Jean-Louis Des Rosiers, Christine Hue, Louis Horman, Sandrine Beauloye, Christophe Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (01.08.2017)

“...High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose...”

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Journal Article

A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

by Timmermans, Aurélie D Balteau, Magali Gélinas, Roselle Renguet, Edith Ginion, Audrey de Meester, Carole Sakamoto, Kei Balligand, Jean-Luc Bontemps, Françoise Vanoverschelde, Jean-Louis Horman, Sandrine Beauloye, Christophe Bertrand, Luc Published in American journal of physiology. Heart and circulatory physiology (15.06.2014)

“...AMP-activated protein kinase (AMPK), a key cellular sensor of energy, regulates metabolic homeostasis and plays a protective role in the ischemic or diabetic...”

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Journal Article

Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats

by Ménard, Sébastien L Croteau, Etienne Sarrhini, Otman Gélinas, Roselle Brassard, Pascal Ouellet, René Bentourkia, M'hamed van Lier, Johannes E Des Rosiers, Christine Lecomte, Roger Carpentier, André C Published in American Journal of Physiology - Endocrinology and Metabolism (01.05.2010)

“...The purpose of this study was to determine in vivo myocardial energy metabolism and function in a nutritional model of type 2 diabetes. Wistar rats rendered...”

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Journal Article

Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway

by Lauzier, Benjamin Vaillant, Fanny Merlen, Clemence Gélinas, Roselle Bouchard, Bertrand Rivard, Marie-Eve Labarthe, Francois Dolinsky, Vern W Dyck, Jason R.B Allen, Bruce G Chatham, John C Des Rosiers, Christine Published in Journal of molecular and cellular cardiology (2012)

“...Abstract Glutamine, the most abundant amino acid in plasma, has attracted considerable interest for its cardioprotective properties. The primary effect of...”

Journal Article

Reduction in Na+ current by angiotensin II is mediated by PKCα in mouse and human-induced pluripotent stem cell–derived cardiomyocytes

by Mathieu, Sophie, PhD El Khoury, Nabil, MSc Rivard, Katy, PhD Gélinas, Roselle, PhD Goyette, Philippe, PhD Paradis, Pierre, PhD Nemer, Mona, PhD Fiset, Céline, PhD Published in Heart rhythm (2016)

“...Background Ventricular arrhythmias and sudden cardiac deaths are among the leading causes of mortality in patients with heart failure, and the underlying...”

Journal Article

Mouse strain differences in metabolic fluxes and function of ex vivo working hearts

by Vaillant, Fanny Lauzier, Benjamin Poirier, Isabelle Gélinas, Roselle Rivard, Marie-Eve Robillard Frayne, Isabelle Thorin, Eric Des Rosiers, Christine Published in American Journal of Physiology - Heart and Circulatory Physiology (01.01.2014)

“...In mice, genetic background is known to influence various parameters, including cardiac function. Its impact on cardiac energy substrate metabolism-a factor...”

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Journal Article

Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts

by Des Rosiers, Christine Gelinas, Roselle Lauzier, Benjamin Bouchard, Bertrand Brownsey, Roger Thorin, Eric Tardif, Jean-Claude Vaillant, Fanny Published in American Journal of Physiology - Heart and Circulatory Physiology (01.03.2011)

“...Heart rate reduction (HRR) is an important target in the management of patients with chronic stable angina. Most available drugs for HRR, such as β-blockers,...”

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Journal Article

Medium-chain Fatty Acids as Metabolic Therapy in Cardiac Disease

by Labarthe, François Gélinas, Roselle Des Rosiers, Christine Published in Cardiovascular drugs and therapy (01.04.2008)

“...Medium-chain fatty acids (MCFAs) have physical and metabolic properties that are distinct from those of long-chain fatty acids, which make them a readily...”

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Journal Article

Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation

by Khairallah, Ramzi J Khairallah, Maya Gélinas, Roselle Bouchard, Bertrand Young, Martin E Allen, Bruce G Lopaschuk, Gary D Deschepper, Christian F Des Rosiers, Christine Published in Journal of molecular and cellular cardiology (2008)

“...Abstract While the balance between carbohydrates and fatty acids for energy production appears to be crucial for cardiac homeostasis, much remains to be...”

Journal Article

Alterations in carbohydrate metabolism and its regulation in PPARα null mouse hearts

by Gélinas, Roselle Labarthe, François Bouchard, Bertrand Mc Duff, Janie Charron, Guy Young, Martin E Des Rosiers, Christine Published in American Journal of Physiology - Heart and Circulatory Physiology (01.04.2008)

“...Although a shift from fatty acids (FAs) to carbohydrates (CHOs) is considered beneficial for the diseased heart, it is unclear why subjects with FA β-oxidation...”

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Journal Article

Alterations in carbohydrate metabolism and its regulation in PPAR{alpha} null mouse hearts

by Gelinas, Roselle Labarthe, Francois Bouchard, Bertrand Mc Duff, Janie Charron, Guy Young, Martin E Des Rosiers, Christine Published in American journal of physiology. Heart and circulatory physiology (01.04.2008)

“...1 Department of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Quebec, Canada; 2 Centre Hospitalier Régional et Universitaire de...”

Journal Article

Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy

by Dubois‐Deruy, Emilie Gelinas, Roselle Beauloye, Christophe Esfahani, Hrag Michel, Lauriane Y.M Dessy, Chantal Bertrand, Luc Balligand, Jean‐Luc Published in ESC Heart Failure (01.06.2020)

“...Aims The abundance of beta 3‐adrenergic receptors (β3‐ARs) is upregulated in diseased human myocardium. We previously showed that cardiac‐specific expression...”

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Journal Article

O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?

by Mailleux, Florence Gélinas, Roselle Beauloye, Christophe Horman, Sandrine Bertrand, Luc Published in BBA - Molecular Basis of Disease (2016)

“...O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine...”

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