Search Results - "Shah, Ajay M"

Journal Article

Oxidative stress and redox signalling in cardiac hypertrophy and heart failure

by Seddon, Mike Looi, Yee H Shah, Ajay M Published in Heart (British Cardiac Society) (01.08.2007)

“...Substantial evidence suggests the involvement of oxidative stress in the pathophysiology of congestive heart failure and its antecedent conditions such as...”

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Journal Article

Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

by Ting, David T Wittner, Ben S Ligorio, Matteo Vincent Jordan, Nicole Shah, Ajay M Miyamoto, David T Aceto, Nicola Bersani, Francesca Brannigan, Brian W Xega, Kristina Ciciliano, Jordan C Zhu, Huili MacKenzie, Olivia C Trautwein, Julie Arora, Kshitij S Shahid, Mohammad Ellis, Haley L Qu, Na Bardeesy, Nabeel Rivera, Miguel N Deshpande, Vikram Ferrone, Cristina R Kapur, Ravi Ramaswamy, Sridhar Shioda, Toshi Toner, Mehmet Maheswaran, Shyamala Haber, Daniel A Published in Cell reports (Cambridge) (25.09.2014)

“...Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define...”

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Endothelial NADPH Oxidase-2 Promotes Interstitial Cardiac Fibrosis and Diastolic Dysfunction Through Proinflammatory Effects and Endothelial-Mesenchymal Transition

by Murdoch, Colin E., PhD Chaubey, Sanjay, MBBCh, PhD Zeng, Lingfang, PhD Yu, Bin, PhD Ivetic, Aleksander, PhD Walker, Simon J., BSc Vanhoutte, Davy, PhD Heymans, Stephane, MD, PhD Grieve, David J., PhD Cave, Alison C., PhD Brewer, Alison C., PhD Zhang, Min, MD, PhD Shah, Ajay M., MD, FMedSci Published in Journal of the American College of Cardiology (24.06.2014)

“...Objectives This study sought to investigate the effect of endothelial dysfunction on the development of cardiac hypertrophy and fibrosis. Background...”

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Journal Article

Cardiovascular disease, heart failure and COVID-19

by Faconti, Luca Chowienczyk, Philip J Shah, Ajay M Published in Journal of the renin-angiotensin-aldosterone system (01.05.2020)

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Journal Article

Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling

by De Virgiliis, Francesco Hutson, Thomas H Palmisano, Ilaria Amachree, Sarah Miao, Jian Zhou, Luming Todorova, Rositsa Thompson, Richard Danzi, Matt C Lemmon, Vance P Bixby, John L Wittig, Ilka Shah, Ajay M Di Giovanni, Simone Published in Nature communications (21.12.2020)

“...Overcoming the restricted axonal regenerative ability that limits functional repair following a central nervous system injury remains a challenge. Here we...”

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Journal Article

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

by Edward R. Duncan Paul A. Crossey Simon Walker Narayana Anilkumar Lucilla Poston Gillian Douglas Vivienne A. Ezzat Stephen B. Wheatcroft Ajay M. Shah Mark I. Kearney Published in Diabetes (New York, N.Y.) (01.12.2008)

“...Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo Edward R. Duncan 1 , Paul A. Crossey 1 , Simon Walker 1 , Narayana Anilkumar...”

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Journal Article

IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance

by Stephen B. Wheatcroft Mark T. Kearney Ajay M. Shah Vivienne A. Ezzat John R. Miell Michael Modo Stephen C.R. Williams Will P. Cawthorn Gema Medina-Gomez Antonio Vidal-Puig Jaswinder K. Sethi Paul A. Crossey Published in Diabetes (New York, N.Y.) (01.02.2007)

“...IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance Stephen B. Wheatcroft 1 , Mark T. Kearney 1 , Ajay M. Shah 2 ,...”

Journal Article

MRI-based prediction of adverse cardiac remodeling after murine myocardial infarction

by Andrea Protti Xuebin Dong Alexander Sirker Rene Botnar Ajay M. Shah Published in American Journal of Physiology - Heart and Circulatory Physiology (01.08.2012)

“...Myocardial infarction (MI) results in adverse cardiac remodeling leading to heart failure and increased mortality. Experimental mouse models of MI are...”

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Journal Article

Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease

by Hussain, Shazia T Paul, Matthias Plein, Sven McCann, Gerry P Shah, Ajay M Marber, Michael S Chiribiri, Amedeo Morton, Geraint Redwood, Simon MacCarthy, Philip Schuster, Andreas Ishida, Masaki Westwood, Mark A Perera, Divaka Nagel, Eike Published in Journal of cardiovascular magnetic resonance (19.09.2012)

“...In patients with stable coronary artery disease (CAD), decisions regarding revascularisation are primarily driven by the severity and extent of coronary...”

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Journal Article

Sympathetic activation increases NO release from eNOS but neither eNOS nor nNOS play an essential role in exercise hyperemia in the human forearm

by Husain Shabeeh Michael Seddon Sally Brett Narbeh Melikian Barbara Casadei Ajay M. Shah Phil Chowienczyk Published in American Journal of Physiology - Heart and Circulatory Physiology (01.05.2013)

“...Nitric oxide (NO) release from endothelial NO synthase (eNOS) and/or neuronal NO synthase (nNOS) could be modulated by sympathetic nerve activity and...”

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Journal Article

Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload

by Husain Shabeeh Narbeh Melikian Rafal Dworakowski Barbara Casadei Phil Chowienczyk Ajay M. Shah Published in American Journal of Physiology - Heart and Circulatory Physiology (01.05.2013)

“...Endothelial nitric oxide synthase (eNOS) was assumed to be the only source of nitric oxide (NO) involved in the regulation of human coronary blood flow (CBF)...”

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Journal Article

Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology

by Alkystis Phinikaridou Marcelo E. Andia Ajay M. Shah René M. Botnar Published in American Journal of Physiology - Heart and Circulatory Physiology (15.12.2012)

“...Molecular imaging of the cardiovascular system heavily relies on the development of new imaging probes and technologies to facilitate visualization of...”

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Journal Article

Inducible Nitric Oxide Synthase Has Divergent Effects on Vascular and Metabolic Function in Obesity

by Brian T. Noronha Jian-Mei Li Stephen B. Wheatcroft Ajay M. Shah Mark T. Kearney Published in Diabetes (New York, N.Y.) (01.04.2005)

“...Inducible Nitric Oxide Synthase Has Divergent Effects on Vascular and Metabolic Function in Obesity Brian T. Noronha , Jian-Mei Li , Stephen B. Wheatcroft ,...”

Journal Article

Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species

by Edward R. Duncan Simon J. Walker Vivienne A. Ezzat Stephen B. Wheatcroft Jian-Mei Li Ajay M. Shah Mark T. Kearney Published in American Journal of Physiology - Endocrinology And Metabolism (01.11.2007)

“...Insulin resistance is well established as an independent risk factor for the development of type 2 diabetes and cardiovascular atherosclerosis. Most studies...”

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Journal Article

Genome-wide expression patterns in physiological cardiac hypertrophy

by Drozdov, Ignat Tsoka, Sophia Ouzounis, Christos A Shah, Ajay M Published in BMC genomics (11.10.2010)

“...Genome-wide expression patterns in physiological cardiac hypertrophy. Co-expression patterns in physiological cardiac hypertrophy In this study, the first...”

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Journal Article

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

by Shah, Ajay M, Prof Mann, Douglas L, Prof Published in The Lancet (British edition) (2011)

“...Summary Chronic heart failure continues to impose a substantial health-care burden, despite recent treatment advances. The key pathophysiological process that...”

Journal Article

Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells

by Liu, Huibing Wang, Libo Pan, Yating Wang, Xuehui Ding, Yuan Zhou, Chaoyuan Shah, Ajay M Zhao, Guoan Zhang, Min Published in JACC. Basic to translational science (01.01.2020)

“...[Display omitted] •The reactive oxygen species–generating enzyme Nox2 is up-regulated in the leaflets of both rabbit and human with CAVD.•Nox2 is markedly...”

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Journal Article

Potential Effect of Brexit on Cardiovascular Translational Science

by Shah, Ajay M., MD Mann, Douglas L., MD, FACC Published in JACC. Basic to translational science (2016)

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NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

by Min Zhang Alison C. Brewer Katrin Schröder Celio X. C. Santos David J. Grieve Minshu Wang Narayana Anilkumar Bin Yu Xuebin Dong Simon J. Walker Ralf P. Brandes Ajay M. Shah Salvador Moncada Published in Proceedings of the National Academy of Sciences - PNAS (19.10.2010)

“...Cardiac failure occurs when the heart fails to adapt to chronic stresses. Reactive oxygen species (ROS)-dependent signaling is implicated in cardiac stress...”

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Journal Article

Contractile Function During Angiotensin-II Activation

by Zhang, Min, MD, PhD Prosser, Benjamin L., PhD Bamboye, Moradeke A., PhD Gondim, Antonio N.S., PhD Santos, Celio X., PhD Martin, Daniel, PhD Ghigo, Alessandra, PhD Perino, Alessia, PhD Brewer, Alison C., PhD Ward, Christopher W., PhD Hirsch, Emilio, PhD Lederer, W. Jonathan, MD, PhD Shah, Ajay M., MD Published in Journal of the American College of Cardiology (2015)

“...Abstract Background Renin-angiotensin system activation is a feature of many cardiovascular conditions. Activity of myocardial reduced nicotinamide adenine...”

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