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  • Your search results: "Shi, Tianlai"
Showing 1 - 20 results of 22 for search '"Shi, Tianlai"', query time: 1.15s Narrow search
  • 1
    Cover Image Journal Article
    Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7
    by Mattarocci, Stefano   Shyian, Maksym   Lemmens, Laure   Damay, Pascal   Altintas, Dogus Murat   Shi, Tianlai   Bartholomew, Clinton R   Thomä, Nicolas H   Hardy, Christopher F J   Shore, David Published in Cell reports (Cambridge) (10.04.2014)
    “...The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been implicated in DNA replication control from yeast to metazoans...”
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  • 2
    Cover Image Journal Article
    Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends
    by Mattarocci, Stefano   Reinert, Julia K   Bunker, Richard D   Fontana, Gabriele A   Shi, Tianlai   Klein, Dominique   Cavadini, Simone   Faty, Mahamadou   Shyian, Maksym   Hafner, Lukas   Shore, David   Thomä, Nicolas H   Rass, Ulrich Published in Nature structural & molecular biology (01.07.2017)
    “...In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chromosome ends. In mammalian cells, Rif1 is not telomeric,...”
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  • 3
    Cover Image Journal Article
    Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo
    by Javanbakht, Hassan   Mueller, Henrik   Walther, Johanna   Zhou, Xue   Lopez, Anaïs   Pattupara, Thushara   Blaising, Julie   Pedersen, Lykke   Albæk, Nanna   Jackerott, Malene   Shi, Tianlai   Ploix, Corinne   Driessen, Wouter   Persson, Robert   Ravn, Jacob   Young, John A.T   Ottosen, Søren Published in Molecular therapy. Nucleic acids (01.06.2018)
    “...Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as...”
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  • 4
    Cover Image Journal Article
    Global control of DNA replication timing by the budding yeast telomere protein Rif1
    by Lemmens, Laure   Mattarocci, Stefano   Marcomini, Isabella   Shi, Tianlai   Follonier, Cindy   Lopes, Massimo   Thomä, Nicolas   Shore, David Published in Epigenetics & chromatin (18.03.2013)
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  • 5
    Cover Image Journal Article
    Discrete spatio-temporal regulation of tyrosine phosphorylation directs influenza A virus M1 protein towards its function in virion assembly
    by Mecate-Zambrano, Angeles   Sukumar, Swathi   Seebohm, Guiscard   Ciminski, Kevin   Schreiber, Andre   Anhlan, Darisuren   Greune, Lilo   Wixler, Ludmilla   Grothe, Stephanie   Stein, Nora Caroline   Schmidt, M. Alexander   Langer, Klaus   Schwemmle, Martin   Shi, Tianlai   Ludwig, Stephan   Boergeling, Yvonne
    edited by Fontoura, Beatriz M
    Published in PLoS pathogens (31.08.2020)
    “...Small RNA viruses only have a very limited coding capacity, thus most viral proteins have evolved to fulfill multiple functions. The highly conserved matrix...”
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  • 6
    Cover Image Journal Article
    A novel mechanism-based pharmacokinetic–pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria
    by Kristoffersson, Anders N   Bissantz, Caterina   Okujava, Rusudan   Haldimann, Andreas   Walter, Isabelle   Shi, Tianlai   Zampaloni, Claudia   Nielsen, Elisabet I Published in Journal of antimicrobial chemotherapy (01.02.2020)
    “...Abstract Background Diazabicyclooctanes (DBOs) are an increasingly important group of non β-lactam β-lactamase inhibitors, employed clinically in combinations...”
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  • 7
    Cover Image Journal Article
    Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions
    by Shi, Tianlai   Bunker, Richard D   Mattarocci, Stefano   Ribeyre, Cyril   Faty, Mahamadou   Gut, Heinz   Scrima, Andrea   Rass, Ulrich   Rubin, Seth M   Shore, David   Thomä, Nicolas H Published in Cell (Cambridge) (06.06.2013)
    “...Yeast telomeres comprise irregular TG1-3 DNA repeats bound by the general transcription factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a...”
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  • 8
    Cover Image Patent
    Assay for compounds having activity against influenza
    by SHI, Tianlai
    07.02.2019
    “...The present invention provides a method for identifying a substance capable of inhibiting at least one activity of an RNA-dependent RNA polymerase (RdRp)...”
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  • 9
    Cover Image Patent
    ASSAY FOR COMPOUNDS HAVING ACTIVITY AGAINST INFLUENZA
    by SHI, Tianlai
    12.12.2018
    “...The present invention provides a method for identifying a substance capable of inhibiting at least one activity of an RNA-dependent RNA polymerase (RdRp)...”
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  • 10
    Cover Image Patent
    ASSAY FOR COMPOUNDS HAVING ACTIVITY AGAINST INFLUENZA
    by SHI, Tianlai
    10.08.2017
    “...The present invention provides a method for identifying a substance capable of inhibiting at least one activity of an RNA-dependent RNA polymerase (RdRp)...”
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  • 11
    Cover Image Journal Article
    Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions
    by Shi, Tianlai   Bunker, Richard D   Mattarocci, Stefano   Ribeyre, Cyril   Faty, Mahamadou   Gut, Heinz   Scrima, Andrea   Rass, Ulrich   Rubin, Seth M   Shore, David   Thomä, Nicolas H Published in Cell (Cambridge)
    “...Yeast telomeres comprise irregular TG₁₋₃ DNA repeats bound by the general transcription factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a...”
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  • 12
    Cover Image Publication
    A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria
    by Kristoffersson, Anders N   Bissantz, Caterina   Okujava, Rusudan   Haldimann, Andreas   Walter, Isabelle   Shi, Tianlai   Zampaloni, Claudia   Nielsen, Elisabet I Published in Journal of Antimicrobial Chemotherapy (2020)
    “...BACKGROUND: Diazabicyclooctanes (DBOs) are an increasingly important group of non β-lactam β-lactamase inhibitors, employed clinically in combinations such as...”
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  • 13
    Cover Image Patent
    5, 7-DIAZAINDOLE AND 5, 7-DIAZAINDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
    by WU, Jun   SHEN, Hong   WANG, Lisha   TAN, Xuefei   LIU, Yongfu   SHI, Tianlai
    10.08.2017
    “...The present invention relates to a specific compound having the formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,...”
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  • 14
    Cover Image Patent
    6,7-DIAZAINDAZOLE AND 6,7-DIAZAINDOLE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF
    by WU, Jun   SHEN, Hong   CUMMING, John Graham   WANG, Lisha   TAN, Xuefei   LIU, Yongfu   SHI, Tianlai
    10.08.2017
    “...Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal,...”
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  • 15
    Cover Image Patent
    BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
    by WU, Jun   SHEN, Hong   ZBINDEN, Katrin Groebke   WANG, Lisha   TAN, Xuefei   KUHN, Bernd   LIU, Yongfu   SHI, Tianlai
    10.08.2017
    “...The present invention relates to a compound having the formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug,...”
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  • 16
    Cover Image Patent
    PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
    by WU, Jun   SHEN, Hong   LI, Dongbo   CUMMING, John Graham   WANG, Lisha   TAN, Xuefei   LIU, Yongfu   SHI, Tianlai
    10.08.2017
    “...Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal,...”
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  • 17
    Cover Image Patent
    4, 7-DIAZAINDOLE AND 4, 7-DIAZAINDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
    by WU, Jun   SHEN, Hong   ZBINDEN, Katrin Groebke   NEIDHART, Werner   WANG, Lisha   TAN, Xuefei   LIU, Yongfu   KUHN, Bernd   SHI, Tianlai
    10.08.2017
    “...The present invention relates to a compound having the formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug,...”
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  • 18
    Cover Image Patent
    PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
    by WU, Jun   SHEN, Hong   ZBINDEN, Katrin Groebke   TANG, Guozhi   QIU, Zongxing   WANG, Lisha   TAN, Xuefei   LIU, Yongfu   KUHN, Bernd   WU, Guolong   SHI, Tianlai
    10.08.2017
    “...Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal,...”
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  • 19
    Cover Image Patent
    PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF
    by WU, Jun   SHEN, Hong   LI, Dongbo   NEIDHART, Werner   WANG, Lisha   TAN, Xuefei   LIU, Yongfu   SHI, Tianlai   WU, Guolong
    10.08.2017
    “...Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal,...”
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  • 20
    Cover Image Publication
    Structural basis for Rap1-Rif1-Rif2 assembly : insights into budding yeast telomere architecture and functions
    by Lingner, Joachim   Thomä, Nicolas   Gasser, Susan M   Tianlai, Shi
    01.01.2012
    “...Telomeres form the ends of eukaryotic linear chromosomes and are composed of specialized nucleoprotein complexes. They have been the subject of intense...”
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