Search Results - "Shore, David"

Journal Article

Divergence and Convergence of Royalty Determinations between Compulsory Licensing under the TRIPS Agreement and Ongoing Royalties as an Equitable Remedy

by Shore, David Published in American journal of law & medicine (01.03.2020)

“...Patent rights are recognized as a property asset with an attendant right to exclude. However, recent policy developments highlight that the right to exclude is...”

Journal Article

Exclusive Drug Labeling Rights as a New Incentive for Contribution to a Communal Biomarker Resource

by Shore, David Published in American journal of law & medicine (01.11.2018)

“...Biomarkers are an important tool in modern drug development. The FDA has posited that increased use of biomarkers in clinical trials can accelerate...”

Journal Article

Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase

by Shore, David Bianchi, Alessandro Published in The EMBO journal (19.08.2009)

“...The conventional DNA polymerase machinery is unable to fully replicate the ends of linear chromosomes. To surmount this problem, nearly all eukaryotes use the...”

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Journal Article

Anticheckpoint pathways at telomeres in yeast

by Ribeyre, Cyril Shore, David Published in Nature structural & molecular biology (12.02.2012)

“...Telomeres hide (or 'cap') chromosome ends from DNA-damage surveillance mechanisms that arrest the cell cycle and promote repair, but the checkpoint status of...”

Journal Article

ChECing out Rif1 action in freely cycling cells

by Hafner, Lukas Hafner, Lukas Shore, David Shore, David Mattarocci, Stefano Mattarocci, Stefano Published in Current genetics (05.04.2019)

“...In buddying yeast, like all eukaryotes examined so far, DNA replication is under temporal control, such that some origins fire early and some late during S...”

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Establishing nucleosome architecture and stability at promoters: Roles of pioneer transcription factors and the RSC chromatin remodeler

by Kubik, Slawomir Bruzzone, Maria Jessica Shore, David Published in BioEssays (01.05.2017)

“...Improvements in deep sequencing, together with methods to rapidly deplete essential transcription factors (TFs) and chromatin remodelers, have recently led to...”

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Journal Article

TFIID or not TFIID, a continuing transcriptional SAGA

by Kubik, Slawomir Bruzzone, Maria Jessica Shore, David Published in The EMBO journal (01.02.2017)

“...Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant...”

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Journal Article

Regulation of telomere addition at DNA double-strand breaks

by Ribeyre, Cyril Shore, David Published in Chromosoma (01.06.2013)

“...Telomeres constitute the ends of linear eukaryotic chromosomes. Due to the conventional mode of DNA replication, telomeric DNA erodes at each cell division. To...”

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Journal Article

Opposing chromatin remodelers control transcription initiation frequency and start site selection

by Kubik, Slawomir Bruzzone, Maria Jessica Challal, Drice Dreos, René Mattarocci, Stefano Bucher, Philipp Libri, Domenico Shore, David Published in Nature structural & molecular biology (01.08.2019)

“...Precise nucleosome organization at eukaryotic promoters is thought to be generated by multiple chromatin remodeler (CR) enzymes and to affect transcription...”

Journal Article

A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

by Wu, Ying Cho, MyungSam Shore, David Song, Manki Choi, JungAh Jiang, Tao Deng, Yong-Qiang Bourgeois, Melissa Almli, Lynn Yang, Hua Chen, Li-Mei Shi, Yi Qi, Jianxu Li, An Yi, Kye Sook Chang, MinSeok Bae, Jin Soo Lee, HyunJoo Shin, JiYoung Stevens, James Hong, SeoungSuh Qin, Cheng-Feng Gao, George F Chang, Shin Jae Donis, Ruben O Published in Nature communications (21.07.2015)

“...Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs)...”

Journal Article

Females Scan More Than Males: A Potential Mechanism for Sex Differences in Recognition Memory

by Jennifer J. Heisz Molly M. Pottruff David I. Shore Published in Psychological science (01.07.2013)

“...Recognition-memory tests reveal individual differences in episodic memory; however, by themselves, these tests provide little information regarding the stage...”

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Journal Article

Today's Leadership Lesson: Mind the Wildlife and Prepare for Tomorrow's Disruption

by Shore, David A Published in Journal of health communication (02.04.2020)

“...As the world reacts with unprecedented efforts to contain the COVID-19 pandemic, the role of organizational leaders is to embark on a parallel track to keep...”

Journal Article

Exploring the Role of the Amplitude Envelope in Duration Estimation

by Vallet, Guillaume T Shore, David I Schutz, Michael Published in Perception (London) (01.07.2014)

“...A sound's duration provides important information about the event producing it. Although many of the sounds we hear every day are ‘percussive’ in nature (ie...”

Journal Article

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition

by Damay, Pascal Bianchi, Alessandro Lemmens, Laure Puglisi, Andrea Shore, David Published in The EMBO journal (03.09.2008)

“...The budding yeast Cdc13, Stn1 and Ten1 (CST) proteins are proposed to function as an RPA‐like complex at telomeres that protects (‘caps’) chromosome ends and...”

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Journal Article

Robotic assisted laparoscopic excision of a renal schwannoma from a community hospital: A case report

by Madueke, Ikenna Shore, David Published in Urology case reports (01.07.2019)

“...Renal schwannomas are an extremely rare renal tumor with possibility for malignant conversion. Although reports are scant, most reports have been presented...”

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Journal Article

DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1

by Ribeyre, Cyril Ribaud, Virginie Shore, David Damay, Pascal Published in The EMBO journal (04.01.2012)

“...Telomere repeats in budding yeast are maintained at a constant average length and protected (‘capped’), in part, by mechanisms involving the TG1−3...”

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Journal Article

Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

by Mattarocci, Stefano Shyian, Maksym Lemmens, Laure Damay, Pascal Altintas, Dogus Murat Shi, Tianlai Bartholomew, Clinton R Thomä, Nicolas H Hardy, Christopher F J Shore, David Published in Cell reports (Cambridge) (10.04.2014)

“...The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been implicated in DNA replication control from yeast to metazoans...”

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Journal Article

Mortality and cancer incidence among underground uranium miners in the Czech Republic 1977–1992

by Kelly-Reif, Kaitlin Sandler, Dale P Shore, David Schubauer-Berigan, Mary Troester, Melissa A Nylander-French, Leena Richardson, David B Published in Occupational and environmental medicine (London, England) (01.08.2019)

“...ObjectivesUranium miners in Příbram, Czech Republic were exposed to low and moderate levels of radon gas and other hazards. It is unknown whether these hazards...”

Journal Article

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

by Fontana, Gabriele A Hess, Daniel Reinert, Julia K Mattarocci, Stefano Falquet, Benoît Klein, Dominique Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature communications (10.06.2019)

“...Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular...”

Journal Article

Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

by Mattarocci, Stefano Reinert, Julia K Bunker, Richard D Fontana, Gabriele A Shi, Tianlai Klein, Dominique Cavadini, Simone Faty, Mahamadou Shyian, Maksym Hafner, Lukas Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature structural & molecular biology (01.07.2017)

“...In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chromosome ends. In mammalian cells, Rif1 is not telomeric,...”

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