Search Results - "Single-Blind Method"

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Randomized Trial of Thymectomy in Myasthenia Gravis

by Wolfe, Gil I Kaminski, Henry J Aban, Inmaculada B Minisman, Greg Kuo, Hui-Chien Marx, Alexander Ströbel, Philipp Mazia, Claudio Oger, Joel Cea, J. Gabriel Heckmann, Jeannine M Evoli, Amelia Nix, Wilfred Ciafaloni, Emma Antonini, Giovanni Witoonpanich, Rawiphan King, John O Beydoun, Said R Chalk, Colin H Barboi, Alexandru C Amato, Anthony A Shaibani, Aziz I Katirji, Bashar Lecky, Bryan R.F Buckley, Camilla Vincent, Angela Dias-Tosta, Elza Yoshikawa, Hiroaki Waddington-Cruz, Márcia Pulley, Michael T Rivner, Michael H Kostera-Pruszczyk, Anna Pascuzzi, Robert M Jackson, Carlayne E Garcia Ramos, Guillermo S Verschuuren, Jan J.G.M Massey, Janice M Kissel, John T Werneck, Lineu C Benatar, Michael Barohn, Richard J Tandan, Rup Mozaffar, Tahseen Conwit, Robin Odenkirchen, Joanne Sonett, Joshua R Jaretzki, Alfred Newsom-Davis, John Cutter, Gary R Published in The New England journal of medicine (11.08.2016)

“...In patients with nonthymomatous myasthenia gravis, thymectomy plus prednisone was associated with better clinical outcomes than prednisone alone. Patients...”

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Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage

by Anderson, Craig S Heeley, Emma Huang, Yining Wang, Jinchao Wang, Jiguang Stapf, Christian Delcourt, Candice Lindley, Richard Robinson, Thompson Lavados, Pablo Neal, Bruce Hata, Jun Arima, Hisatomi Parsons, Mark Li, Qiang Li, Yuechun Heritier, Stephane Woodward, Mark Simes, R. John Davis, Stephen M Chalmers, John Published in The New England journal of medicine (20.06.2013)

“...In this trial involving patients with intracerebral hemorrhage, intensive BP lowering (target systolic BP <140 mm Hg) did not significantly reduce the rate of...”

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A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

by Heyland, Daren Muscedere, John Wischmeyer, Paul E Cook, Deborah Jones, Gwynne Albert, Martin Elke, Gunnar Berger, Mette M Day, Andrew G Published in The New England journal of medicine (18.04.2013)

“...This trial involving critically ill adults with multiorgan failure who were receiving mechanical ventilation showed that early provision of glutamine and...”

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Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study

by Lammer, Johannes Lammer, Johannes Malagari, Katarina Malagari, Katarina Vogl, Thomas Vogl, Thomas Pilleul, Frank Pilleul, Frank Denys, Alban Denys, Alban Watkinson, Anthony Watkinson, Anthony Pitton, Michael Pitton, Michael Sergent, Geraldine Sergent, Geraldine Pfammatter, Thomas Pfammatter, Thomas Terraz, Sylvain Terraz, Sylvain Benhamou, Yves Benhamou, Yves Avajon, Yves Avajon, Yves Gruenberger, Thomas Gruenberger, Thomas Pomoni, Maria Pomoni, Maria Langenberger, Herbert Langenberger, Herbert Schuchmann, Marcus Schuchmann, Marcus Dumortier, Jerome Dumortier, Jerome Mueller, Christian Mueller, Christian Chevallier, Patrick Chevallier, Patrick Lencioni, Riccardo Lencioni, Riccardo Published in Cardiovascular and interventional radiology (01.02.2010)

“...Transcatheter arterial chemoembolization (TACE) offers a survival benefit to patients with intermediate hepatocellular carcinoma (HCC). A widely accepted TACE...”

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Improvement of Intraoperative Antibiotic Prophylaxis in Prolonged Cardiac Surgery by Automated Alerts in the Operating Room

by Giorgio Zanetti Hugh L. Flanagan Lawrence H. Cohn Richard Giardina Richard Platt Published in Infection control and hospital epidemiology (01.01.2003)

“...To assess the impact of an automated intraoperative alert to redose prophylactic antibiotics in prolonged cardiac operations. Randomized, controlled,...”

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Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation

by Kuck, Karl-Heinz Brugada, Josep Fürnkranz, Alexander Metzner, Andreas Ouyang, Feifan Chun, K.R. Julian Elvan, Arif Arentz, Thomas Bestehorn, Kurt Pocock, Stuart J Albenque, Jean-Paul Tondo, Claudio Published in The New England journal of medicine (09.06.2016)

“...Over 700 patients with drug-refractory paroxysmal atrial fibrillation were randomly assigned to cryoballoon or radiofrequency ablation. Cryoballoon ablation...”

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Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

by Albers, Gregory W Marks, Michael P Kemp, Stephanie Christensen, Soren Tsai, Jenny P Ortega-Gutierrez, Santiago McTaggart, Ryan A Torbey, Michel T Kim-Tenser, May Leslie-Mazwi, Thabele Sarraj, Amrou Kasner, Scott E Ansari, Sameer A Yeatts, Sharon D Hamilton, Scott Mlynash, Michael Heit, Jeremy J Zaharchuk, Greg Kim, Sun Carrozzella, Janice Palesch, Yuko Y Demchuk, Andrew M Bammer, Roland Lavori, Philip W Broderick, Joseph P Lansberg, Maarten G Published in The New England journal of medicine (22.02.2018)

“...In this trial in patients with stroke who had a mismatch between sizes of early infarction and a hypoperfused brain region, endovascular thrombectomy at 6 to...”

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How scientists fool themselves - and how they can stop

by Nuzzo, Regina Published in Nature (London) (08.10.2015)

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Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial

by Fretland, Åsmund Avdem Dagenborg, Vegar Johansen Bjørnelv, Gudrun Maria Waaler Kazaryan, Airazat M Kristiansen, Ronny Fagerland, Morten Wang Hausken, John Tønnessen, Tor Inge Abildgaard, Andreas Barkhatov, Leonid Yaqub, Sheraz Røsok, Bård I Bjørnbeth, Bjørn Atle Andersen, Marit Helen Flatmark, Kjersti Aas, Eline Edwin, Bjørn Published in Annals of surgery (01.02.2018)

“...OBJECTIVE:To perform the first randomized controlled trial to compare laparoscopic and open liver resection. SUMMARY BACKGROUND DATA:Laparoscopic liver...”

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The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders Compared With Diagnosis-Specific Protocols for Anxiety Disorders: A Randomized Clinical Trial

by Barlow, David H Farchione, Todd J Bullis, Jacqueline R Gallagher, Matthew W Murray-Latin, Heather Sauer-Zavala, Shannon Bentley, Kate H Thompson-Hollands, Johanna Conklin, Laren R Boswell, James F Ametaj, Amantia Carl, Jenna R Boettcher, Hannah T Cassiello-Robbins, Clair Published in JAMA psychiatry (Chicago, Ill.) (01.09.2017)

“...IMPORTANCE: Transdiagnostic interventions have been developed to address barriers to the dissemination of evidence-based psychological treatments, but only a...”

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Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter Blinded Randomized Noninferiority Study of 1992 Cases (Pivotal Study)

by Mukhopadhyay, Sanjay Feldman, Michael D Abels, Esther Ashfaq, Raheela Beltaifa, Senda Cacciabeve, Nicolas G Cathro, Helen P Cheng, Liang Cooper, Kumarasen Dickey, Glenn E Gill, Ryan M Heaton, Robert P Kerstens, René Lindberg, Guy M Malhotra, Reenu K Mandell, James W Manlucu, Ellen D Mills, Anne M Mills, Stacey E Moskaluk, Christopher A Nelis, Mischa Patil, Deepa T Przybycin, Christopher G Reynolds, Jordan P Rubin, Brian P Saboorian, Mohammad H Salicru, Mauricio Samols, Mark A Sturgis, Charles D Turner, Kevin O Wick, Mark R Yoon, Ji Y Zhao, Po Taylor, Clive R Published in The American journal of surgical pathology (01.01.2018)

“...Most prior studies of primary diagnosis in surgical pathology using whole slide imaging (WSI) versus microscopy have focused on specific organ systems or...”

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Effect of Laparoscopic-Assisted Resection vs Open Resection on Pathological Outcomes in Rectal Cancer: The ALaCaRT Randomized Clinical Trial

by Stevenson, Andrew R. L Solomon, Michael J Lumley, John W Hewett, Peter Clouston, Andrew D Gebski, Val J Davies, Lucy Wilson, Kate Hague, Wendy Simes, John Published in JAMA : the journal of the American Medical Association (06.10.2015)

“...IMPORTANCE: Laparoscopic procedures are generally thought to have better outcomes than open procedures. Because of anatomical constraints, laparoscopic rectal...”

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Haemodynamic consequences of changing bicarbonate and calcium concentrations in haemodialysis fluids

by Gabutti, Luca Bianchi, Giorgia Soldini, Davide Marone, Claudio Burnier, Michel Published in Nephrology, dialysis, transplantation (01.03.2009)

“...Background. In a previous study we demonstrated that mild metabolic alkalosis resulting from standard bicarbonate haemodialysis induces hypotension. In this...”

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A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

by Berkhemer, Olvert A Fransen, Puck S.S Beumer, Debbie van den Berg, Lucie A van den Berg, René van den Berg, Jan S.P Lingsma, Hester F Yoo, Albert J Schonewille, Wouter J Vos, Jan Albert Nederkoorn, Paul J Wermer, Marieke J.H van Walderveen, Marianne A.A Staals, Julie Hofmeijer, Jeannette van Oostayen, Jacques A Lycklama à Nijeholt, Geert J Boiten, Jelis Brouwer, Patrick A Emmer, Bart J de Bruijn, Sebastiaan F van Dijk, Lukas C van Dijk, Ewoud J Kappelle, L. Jaap Lo, Rob H de Vries, Joost de Kort, Paul L.M van Rooij, Willem Jan J van Hasselt, Boudewijn A.A.M Aerden, Leo A.M Dallinga, René J Visser, Marieke C Bot, Joseph C.J Vroomen, Patrick C Eshghi, Omid Schreuder, Tobien H.C.M.L Heijboer, Roel J.J Keizer, Koos Tielbeek, Alexander V den Hertog, Heleen M Gerrits, Dick G van den Berg-Vos, Renske M Karas, Giorgos B Steyerberg, Ewout W Flach, H. Zwenneke Marquering, Henk A Sprengers, Marieke E.S Jenniskens, Sjoerd F.M Beenen, Ludo F.M Koudstaal, Peter J van Zwam, Wim H Roos, Yvo B.W.E.M van der Lugt, Aad van Oostenbrugge, Robert J Majoie, Charles B.L.M Dippel, Diederik W.J Published in The New England journal of medicine (01.01.2015)

“...In patients with acute ischemic stroke due to a proximal intracranial arterial occlusion, intraarterial treatment (with retrievable stents in 82% of patients)...”

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Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

by Rini, Brian I Plimack, Elizabeth R Stus, Viktor Gafanov, Rustem Hawkins, Robert Nosov, Dmitry Pouliot, Frédéric Alekseev, Boris Soulières, Denis Melichar, Bohuslav Vynnychenko, Ihor Kryzhanivska, Anna Bondarenko, Igor Azevedo, Sergio J Borchiellini, Delphine Szczylik, Cezary Markus, Maurice McDermott, Raymond S Bedke, Jens Tartas, Sophie Chang, Yen-Hwa Tamada, Satoshi Shou, Qiong Perini, Rodolfo F Chen, Mei Atkins, Michael B Powles, Thomas Published in The New England journal of medicine (21.03.2019)

“...Among patients with advanced renal-cell carcinoma, overall survival and progression-free survival were longer among patients who received pembrolizumab and...”

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Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

by Motzer, Robert J Penkov, Konstantin Haanen, John Rini, Brian Albiges, Laurence Campbell, Matthew T Venugopal, Balaji Kollmannsberger, Christian Negrier, Sylvie Uemura, Motohide Lee, Jae L Vasiliev, Aleksandr Miller, Wilson H Gurney, Howard Schmidinger, Manuela Larkin, James Atkins, Michael B Bedke, Jens Alekseev, Boris Wang, Jing Mariani, Mariangela Robbins, Paul B Chudnovsky, Aleksander Fowst, Camilla Hariharan, Subramanian Huang, Bo di Pietro, Alessandra Choueiri, Toni K Published in The New England journal of medicine (21.03.2019)

“...Among 886 patients with advanced renal-cell cancer, median progression-free survival was 13.8 months among those assigned to avelumab plus axitinib and 7.2...”

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A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

by Mulangu, Sabue Dodd, Lori E Davey, Richard T Tshiani Mbaya, Olivier Proschan, Michael Mukadi, Daniel Lusakibanza Manzo, Mariano Nzolo, Didier Tshomba Oloma, Antoine Ibanda, Augustin Ali, Rosine Coulibaly, Sinaré Levine, Adam C Grais, Rebecca Diaz, Janet Lane, H. Clifford Muyembe-Tamfum, Jean-Jacques the PALM Writing Group Published in The New England journal of medicine (12.12.2019)

“...Ebola transmission has been ongoing in the Democratic Republic of Congo since August 2018. In this trial of MAb114, REGN-EB3, remdesivir, and ZMapp (as the...”

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Phase I/phase II study of blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia

by von Stackelberg, Arend Locatelli, Franco Zugmaier, Gerhard Handgretinger, Rupert Trippett, Tanya M Rizzari, Carmelo Bader, Peter O'Brien, Maureen M Brethon, Benoît Bhojwani, Deepa Schlegel, Paul Gerhardt Borkhardt, Arndt Rheingold, Susan R Cooper, Todd Michael Zwaan, Christian M Barnette, Phillip Messina, Chiara Michel, Gérard DuBois, Steven G Hu, Kuolung Zhu, Min Whitlock, James A Gore, Lia Published in Journal of clinical oncology (20.12.2016)

“...Purpose Blinatumomab is a bispecific T-cell engager antibody construct targeting CD19 on B-cell lymphoblasts. We evaluated the safety, pharmacokinetics,...”

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Prehabilitation versus Rehabilitation: A Randomized Control Trial in Patients Undergoing Colorectal Resection for Cancer

by Gillis, Chelsia Li, Chao Lee, Lawrence Awasthi, Rashami Augustin, Berson Gamsa, Ann Liberman, A Sender Stein, Barry Charlebois, Patrick Feldman, Liane S Carli, Francesco Published in Anesthesiology (Philadelphia) (01.11.2014)

“...BACKGROUND:The preoperative period (prehabilitation) may represent a more appropriate time than the postoperative period to implement an intervention. The...”

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A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome

by Halmos, Emma P Power, Victoria A Shepherd, Susan J Gibson, Peter R Muir, Jane G Published in Gastroenterology (New York, N.Y. 1943) (2014)

“...Background & Aims A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) often is used to manage functional...”

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