Search Results - "Thomä, Nicolas H"

Journal Article

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

by Sievers, Quinlan L Petzold, Georg Bunker, Richard D Renneville, Aline Słabicki, Mikołaj Liddicoat, Brian J Abdulrahman, Wassim Mikkelsen, Tarjei Ebert, Benjamin L Thomä, Nicolas H Published in Science (American Association for the Advancement of Science) (02.11.2018)

“...The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros...”

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Journal Article

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

by Cavadini, Simone Fischer, Eric S Bunker, Richard D Potenza, Alessandro Lingaraju, Gondichatnahalli M Goldie, Kenneth N Mohamed, Weaam I Faty, Mahamadou Petzold, Georg Beckwith, Rohan E J Tichkule, Ritesh B Hassiepen, Ulrich Abdulrahman, Wassim Pantelic, Radosav S Matsumoto, Syota Sugasawa, Kaoru Stahlberg, Henning Thomä, Nicolas H Published in Nature (London) (31.03.2016)

“...The cullin-RING ubiquitin E3 ligase (CRL) family comprises over 200 members in humans. The COP9 signalosome complex (CSN) regulates CRLs by removing their...”

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Structural insights into Fe–S protein biogenesis by the CIA targeting complex

by Kassube, Susanne A Thoma, Nicolas H Published in Nature structural & molecular biology (01.08.2020)

Journal Article

Determinants and dynamics of genome accessibility

by Bell, Oliver Tiwari, Vijay K Schübeler, Dirk Thomä, Nicolas H Published in Nature reviews. Genetics (01.08.2011)

“...In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome packaging inherently restricts DNA accessibility for regulatory...”

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Journal Article

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

by Fischer, Eric S Böhm, Kerstin Lydeard, John R Yang, Haidi Stadler, Michael B Cavadini, Simone Nagel, Jane Serluca, Fabrizio Acker, Vincent Lingaraju, Gondichatnahalli M Tichkule, Ritesh B Schebesta, Michael Forrester, William C Schirle, Markus Hassiepen, Ulrich Ottl, Johannes Hild, Marc Beckwith, Rohan E J Harper, J Wade Jenkins, Jeremy L Thomä, Nicolas H Published in Nature (London) (07.08.2014)

“...In the 1950s, the drug thalidomide, administered as a sedative to pregnant women, led to the birth of thousands of children with multiple defects. Despite the...”

Journal Article

FANally…A Structure Emerges of the Fanconi Anemia Core Complex

by Aguirre, Jacob D Thomä, Nicolas H Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2020)

“...The Fanconi anemia (FA) core complex is the ~0.9-mDa ubiquitin ligase most frequently mutated in patients with FA. New cryo-electron microscopy (cryo-EM) data...”

Journal Article

DNA damage detection in nucleosomes involves DNA register shifting

by Matsumoto, Syota Cavadini, Simone Bunker, Richard D Grand, Ralph S Potenza, Alessandro Rabl, Julius Yamamoto, Junpei Schenk, Andreas D Schübeler, Dirk Iwai, Shigenori Sugasawa, Kaoru Kurumizaka, Hitoshi Thomä, Nicolas H Published in Nature (London) (01.07.2019)

“...Access to DNA packaged in nucleosomes is critical for gene regulation, DNA replication and DNA repair. In humans, the UV-damaged DNA-binding protein (UV-DDB)...”

Journal Article

Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE

by Schenk, Andreas D Cavadini, Simone Thomä, Nicolas H Genoud, Christel Published in Journal of chemical information and modeling (26.05.2020)

“...Efficient, reproducible and accountable single-particle cryo-electron microscopy structure determination is tedious and often impeded by the lack of a...”

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Journal Article

Crystal structure of the human COP9 signalosome

by Lingaraju, Gondichatnahalli M Bunker, Richard D Cavadini, Simone Hess, Daniel Hassiepen, Ulrich Renatus, Martin Fischer, Eric S Thomä, Nicolas H Published in Nature (London) (14.08.2014)

“...Ubiquitination is a crucial cellular signalling process, and is controlled on multiple levels. Cullin-RING E3 ubiquitin ligases (CRLs) are regulated by the...”

Journal Article

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

by Fontana, Gabriele A Hess, Daniel Reinert, Julia K Mattarocci, Stefano Falquet, Benoît Klein, Dominique Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature communications (10.06.2019)

“...Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular...”

Journal Article

Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

by Mattarocci, Stefano Reinert, Julia K Bunker, Richard D Fontana, Gabriele A Shi, Tianlai Klein, Dominique Cavadini, Simone Faty, Mahamadou Shyian, Maksym Hafner, Lukas Shore, David Thomä, Nicolas H Rass, Ulrich Published in Nature structural & molecular biology (01.07.2017)

“...In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chromosome ends. In mammalian cells, Rif1 is not telomeric,...”

Journal Article

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

by Ostapcuk, Veronika Mohn, Fabio Carl, Sarah H Basters, Anja Hess, Daniel Iesmantavicius, Vytautas Lampersberger, Lisa Flemr, Matyas Pandey, Aparna Thomä, Nicolas H Betschinger, Joerg Bühler, Marc Published in Nature (London) (01.05.2018)

“...De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein (ADNP), have recently been found to underlie Helsmoortel-Van der Aa...”

Journal Article

Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions

by Shi, Tianlai Bunker, Richard D Mattarocci, Stefano Ribeyre, Cyril Faty, Mahamadou Gut, Heinz Scrima, Andrea Rass, Ulrich Rubin, Seth M Shore, David Thomä, Nicolas H Published in Cell (Cambridge) (06.06.2013)

“...Yeast telomeres comprise irregular TG1-3 DNA repeats bound by the general transcription factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a...”

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Journal Article

Regulatory control of DNA end resection by Sae2 phosphorylation

by Cannavo, Elda Johnson, Dominic Andres, Sara N Kissling, Vera M Reinert, Julia K Garcia, Valerie Erie, Dorothy A Hess, Daniel Thomä, Nicolas H Enchev, Radoslav I Peter, Matthias Williams, R Scott Neale, Matt J Cejka, Petr Published in Nature communications (01.10.2018)

“...DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and...”

Journal Article

Structural mechanism of cGAS inhibition by the nucleosome

by Pathare, Ganesh R Decout, Alexiane Glück, Selene Cavadini, Simone Makasheva, Kristina Hovius, Ruud Kempf, Georg Weiss, Joscha Kozicka, Zuzanna Guey, Baptiste Melenec, Pauline Fierz, Beat Thomä, Nicolas H Ablasser, Andrea Published in Nature (London) (01.11.2020)

“...The DNA sensor cyclic GMP-AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer . Upon activation by...”

Journal Article

Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

by Mattarocci, Stefano Shyian, Maksym Lemmens, Laure Damay, Pascal Altintas, Dogus Murat Shi, Tianlai Bartholomew, Clinton R Thomä, Nicolas H Hardy, Christopher F J Shore, David Published in Cell reports (Cambridge) (10.04.2014)

“...The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been implicated in DNA replication control from yeast to metazoans...”

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Journal Article

Rational discovery of molecular glue degraders via scalable chemical profiling

by Mayor-Ruiz, Cristina Bauer, Sophie Brand, Matthias Kozicka, Zuzanna Siklos, Marton Imrichova, Hana Kaltheuner, Ines H Hahn, Elisa Seiler, Kristina Koren, Anna Petzold, Georg Fellner, Michaela Bock, Christoph Müller, André C Zuber, Johannes Geyer, Matthias Thomä, Nicolas H Kubicek, Stefan Winter, Georg E Published in Nature chemical biology (01.11.2020)

“...Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of...”

Journal Article

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

by Slabicki, Mikolaj Kozicka, Zuzanna Petzold, Georg Li, Yen-Der Manojkumar, Manisha Bunker, Richard D Donovan, Katherine A Published in Nature (London) (10.09.2020)

“...Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. 1 Unlike traditional...”

Journal Article

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

by Rabl, Julius Bunker, Richard D Schenk, Andreas D Cavadini, Simone Gill, Mark E Abdulrahman, Wassim Andrés-Pons, Amparo Luijsterburg, Martijn S Ibrahim, Adel F.M Branigan, Emma Aguirre, Jacob D Marceau, Aimee H Guérillon, Claire Bouwmeester, Tewis Hassiepen, Ulrich Peters, Antoine H.F.M Renatus, Martin Gelman, Laurent Rubin, Seth M Mailand, Niels van Attikum, Haico Hay, Ronald T Thomä, Nicolas H Published in Molecular cell (08.08.2019)

“...In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with...”

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An N‐terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

by Hegnauer, Anna Maria Hustedt, Nicole Shimada, Kenji Pike, Brietta L Vogel, Markus Amsler, Philipp Rubin, Seth M van Leeuwen, Fred Guénolé, Aude van Attikum, Haico Thomä, Nicolas H Gasser, Susan M Published in The EMBO journal (12.09.2012)

“...DNA replication fork stalling poses a major threat to genome stability. This is counteracted in part by the intra‐S phase checkpoint, which stabilizes arrested...”

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