Search Results - "Timothy Hinks"

Journal Article

Mucosal‐associated invariant T cells in autoimmunity, immune‐mediated diseases and airways disease

by Hinks, Timothy S. C Published in Immunology (01.05.2016)

“...Summary Mucosal‐associated invariant T (MAIT) cells are a novel class of innate‐like T cells, expressing a semi‐invariant T‐cell receptor (TCR) and able to...”

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Journal Article

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

by Hinks, Timothy S.C., MD Brown, Tom, MD Lau, Laurie C.K., PhD Rupani, Hitasha, MD Barber, Clair, BSc Elliott, Scott, BSc Ward, Jon A., BSc Ono, Junya, BSc Ohta, Shoichiro, MD Izuhara, Kenji, MD Djukanović, Ratko, MD Kurukulaaratchy, Ramesh J., MD Chauhan, Anoop, MD Howarth, Peter H., MD Published in Journal of allergy and clinical immunology (2015)

“...Background Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood. Objective We aimed to...”

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Journal Article

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

by Hinks, Timothy S.C., MD Zhou, Xiaoying, PhD Staples, Karl J., PhD Dimitrov, Borislav D., MD Manta, Alexander, PhD Petrossian, Tanya, PhD Lum, Pek Y., PhD Smith, Caroline G., RN Ward, Jon A., BSc Howarth, Peter H., MD Walls, Andrew F., PhD Gadola, Stephan D., MD Djukanović, Ratko, MD Published in Journal of allergy and clinical immunology (2015)

“...Background Asthma is a chronic inflammatory disease involving diverse cells and mediators whose interconnectivity and relationships to asthma severity are...”

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Journal Article

Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17

by Staples, Karl J., PhD Hinks, Timothy S.C., MB BS Ward, Jon A., BSc (Hons) Gunn, Victoria, BM Smith, Caroline, BA (Hons) Djukanović, Ratko, MD Published in Journal of allergy and clinical immunology (2012)

“...Background Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic...”

Journal Article

Metabolomics analysis identifies different metabotypes of asthma severity

by Reinke, Stacey N Gallart-Ayala, Héctor Gómez, Cristina Checa, Antonio Fauland, Alexander Naz, Shama Kamleh, Muhammad Anas Djukanović, Ratko Hinks, Timothy S C Wheelock, Craig E Published in The European respiratory journal (01.03.2017)

“...In this study, we sought to determine whether asthma has a metabolic profile and whether this profile is related to disease severity.We characterised the serum...”

Journal Article

Biological functions of MAIT cells in tissues

by Klenerman, Paul Hinks, Timothy S.C Ussher, James E Published in Molecular immunology (01.02.2021)

“...•MAIT cells recognise vitamin-B2 metabolites via their semi-invariant TCR.•TCR-independent cytokine-mediated activation extends roles to anti-viral...”

Journal Article

Boosting MAIT cells as immunotherapy: context is everything

by Hinks, Timothy S C Published in Mucosal immunology (01.01.2021)

Journal Article

MAIT cells protect against pulmonary Legionella longbeachae infection

by Wang, Huimeng D'Souza, Criselle Lim, Xin Yi Kostenko, Lyudmila Pediongco, Troi J Eckle, Sidonia B G Meehan, Bronwyn S Shi, Mai Wang, Nancy Li, Shihan Liu, Ligong Mak, Jeffrey Y W Fairlie, David P Iwakura, Yoichiro Gunnersen, Jennifer M Stent, Andrew W Godfrey, Dale I Rossjohn, Jamie Westall, Glen P Kjer-Nielsen, Lars Strugnell, Richard A McCluskey, James Corbett, Alexandra J Hinks, Timothy S C Chen, Zhenjun Published in Nature communications (22.08.2018)

“...Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and...”

Journal Article

Steroid‐induced deficiency of mucosal‐associated invariant T cells in the chronic obstructive pulmonary disease lung. Implications for nontypeable haemophilus influenzae infection...

by Hinks, Timothy S C Wallington, Joshua C Williams, Anthony P Djukanović, Ratko Staples, Karl J Wilkinson, Tom M A Published in American journal of respiratory and critical care medicine (15.11.2016)

“...Mucosal-associated invariant T (MAIT) cells are a recently described abundant, proinflammatory T-cell subset with unknown roles in pulmonary immunity...”

Journal Article

Is there a role for type 2 CD8+ T cells in patients with steroid-resistant asthma?

by Gelfand, Erwin W Hinks, Timothy S.C Published in Journal of allergy and clinical immunology (01.09.2019)

Journal Article

Coal mine dust lung disease in the modern era

by Perret, Jennifer L Plush, Brian Lachapelle, Philippe Hinks, Timothy S.C Walter, Clare Clarke, Philip Irving, Louis Brady, Pat Dharmage, Shyamali C Stewart, Alastair Published in Respirology (Carlton, Vic.) (01.05.2017)

“...ABSTRACT Coal workers’ pneumoconiosis (CWP), as part of the spectrum of coal mine dust lung disease (CMDLD), is a preventable but incurable lung disease that...”

Journal Article

Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load

by Millington, Kerry A Innes, John A Hackforth, Sarah Hinks, Timothy S C Deeks, Jonathan J Dosanjh, Davinder P S Guyot-Revol, Valerie Gunatheesan, Rubamalaar Klenerman, Paul Lalvani, Ajit Published in The Journal of immunology (1950) (15.04.2007)

“...Distinct IFN-gamma and IL-2 profiles of Ag-specific CD4(+) T cells have recently been associated with different clinical disease states and Ag loads in viral...”

Journal Article

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

by Hinks, Timothy S.C Marchi, Emanuele Jabeen, Maisha Olshansky, Moshe Kurioka, Ayako Pediongco, Troi J Meehan, Bronwyn S Kostenko, Lyudmila Turner, Stephen J Corbett, Alexandra J Chen, Zhenjun Klenerman, Paul McCluskey, James Published in Cell reports (Cambridge) (17.09.2019)

“...Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing...”

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Journal Article

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma

by Reinke, Stacey N Galindo-Prieto, Beatriz Skotare, Tomas Broadhurst, David I Singhania, Akul Horowitz, Daniel Djukanović, Ratko Hinks, Timothy S.C Geladi, Paul Trygg, Johan Wheelock, Craig E Published in Analytical chemistry (Washington) (20.11.2018)

“...Integration of multiomics data remains a key challenge in fulfilling the potential of comprehensive systems biology. Multiple-block orthogonal projections to...”

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Journal Article

Multitissue transcriptomics delineates the diversity of airway t cell functions in asthma

by Singhania, Akul Wallington, Joshua C Smith, Caroline G Horowitz, Daniel Staples, Karl J Howarth, Peter H Gadola, Stephan D Djukanović, Ratko Woelk, Christopher H Hinks, Timothy S C Published in American journal of respiratory cell and molecular biology (01.02.2018)

“...Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues. We sought to undertake a comprehensive transcriptomic...”

Journal Article

CD8 + Tc2 cells: underappreciated contributors to severe asthma

by Hinks, Timothy S C Hoyle, Ryan D Gelfand, Erwin W Published in European respiratory review (31.12.2019)

“...The complexity of asthma is underscored by the number of cell types and mediators implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4...”

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Journal Article

Treatment options in type-2 low asthma

by Hinks, Timothy S C Levine, Stewart J Brusselle, Guy G Published in The European respiratory journal (01.01.2021)

“...Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13 are proving highly effective in reducing exacerbations and...”

Journal Article

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

by Leng, Tianqi Akther, Hossain Delowar Hackstein, Carl-Philipp Powell, Kate King, Thomas Friedrich, Matthias Christoforidou, Zoe McCuaig, Sarah Neyazi, Mastura Arancibia-Cárcamo, Carolina V Hagel, Joachim Powrie, Fiona Peres, Raphael Sanches Millar, Val Ebner, Daniel Lamichhane, Rajesh Ussher, James Hinks, Timothy S.C Marchi, Emanuele Willberg, Chris Klenerman, Paul Published in Cell reports (Cambridge) (17.09.2019)

“...MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the...”

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Journal Article

Mycobacterium tuberculosis—Specific Cellular Immune Profiles Suggest Bacillary Persistence Decades after Spontaneous Cure in Untreated Tuberculosis

by Kerry A. Millington Sarah Gooding Timothy S. C. Hinks D. John M. Reynolds Ajit Lalvani Published in The Journal of infectious diseases (01.12.2010)

“...Individuals with self-healed tuberculosis from the preantibiotic era offer a unique insight into the natural history of and protective immunity to...”

Journal Article

MAIT cells contribute to protection against lethal influenza infection in vivo

by van Wilgenburg, Bonnie Loh, Liyen Chen, Zhenjun Pediongco, Troi J Wang, Huimeng Shi, Mai Zhao, Zhe Koutsakos, Marios Nüssing, Simone Sant, Sneha Wang, Zhongfang D'Souza, Criselle Jia, Xiaoxiao Almeida, Catarina F Kostenko, Lyudmila Eckle, Sidonia B G Meehan, Bronwyn S Kallies, Axel Godfrey, Dale I Reading, Patrick C Corbett, Alexandra J McCluskey, James Klenerman, Paul Kedzierska, Katherine Hinks, Timothy S C Published in Nature communications (09.11.2018)

“...Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to...”

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