Search Results - "Tripathi, Timir"

Journal Article

Yeast and Human Nuclear Pore Complexes: Not So Similar After All

by Shav-Tal, Yaron Tripathi, Timir Published in Trends in cell biology (01.08.2018)

“...Nucleoporin subunits that generate the nuclear pore complex (NPC) are highly conserved in evolution. High-resolution structures of the NPC are available, but...”

Journal Article

Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy

by Verma, Stuti Kumar, Ashwini Tripathi, Timir Kumar, Awanish Published in Journal of pharmacy and pharmacology (01.08.2018)

“...Objectives Alzheimer's disease (AD) has become the primary cause of dementia. It shows a progressive cognitive dysfunction with degenerating neurons...”

Journal Article

Structural insights into natural compounds as inhibitors of Fasciola gigantica thioredoxin glutathione reductase

by Shukla, Rohit Shukla, Harish Kalita, Parismita Tripathi, Timir Published in Journal of cellular biochemistry (01.04.2018)

“...Fascioliasis is caused by the helminth parasites of genus Fasciola. Thioredoxin glutathione reductase (TGR) is an important enzyme in parasitic helminths and...”

eBook

Frontiers in Protein Structure, Function, and Dynamics

by Singh, Dev Bukhsh Tripathi, Timir
2020

“...This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a...”

Journal Article

Structural and energetic understanding of novel natural inhibitors of Mycobacterium tuberculosis malate synthase

by Shukla, Rohit Shukla, Harish Tripathi, Timir Published in Journal of cellular biochemistry (01.02.2019)

“...Persistent infection by Mycobacterium tuberculosis requires the glyoxylate shunt. This is a bypass to the tricarboxylic acid cycle in which isocitrate lyase...”

Journal Article

Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility

by Shukla, Harish Shukla, Rohit Sonkar, Amit Pandey, Tripti Tripathi, Timir Published in Scientific reports (21.04.2017)

“...Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the glyoxylate shunt. In the present investigation, we studied the...”

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Journal Article

Structural basis of urea‐induced unfolding of Fasciola gigantica glutathione S‐transferase

by Kalita, Jupitara Shukla, Rohit Tripathi, Timir Published in Journal of cellular physiology (01.04.2019)

“...Glutathione S‐transferases (GSTs) are enzymes that are involved in the detoxification of harmful electrophilic endogenous and exogenous compounds by...”

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Journal Article

Identification and characterization of cytosolic malate dehydrogenase from the liver fluke Fasciola gigantica

by Chetri, Purna Bahadur Shukla, Rohit Tripathi, Timir Published in Scientific reports (07.08.2020)

“...The liver fluke zoonoses, Fasciola spp. are parasitic helminths infecting humans and animals globally. Recent sequencing of the genome of Fasciola gigantica...”

Journal Article

Activity loss by H46A mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site

by Shukla, Rohit Shukla, Harish Tripathi, Timir Published in Tuberculosis (Edinburgh, Scotland) (01.01.2018)

“...Mycobacterium tuberculosis isocitrate lyase (MtbICL) is a crucial enzyme of the glyoxylate cycle and is a validated anti-tuberculosis drug target. Structurally...”

Journal Article

Autophagy Modulation as a Treatment of Amyloid Diseases

by Mputhia, Zoe Hone, Eugene Tripathi, Timir Sargeant, Tim Martins, Ralph Bharadwaj, Prashant Published in Molecules (Basel, Switzerland) (16.09.2019)

“...Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous...”

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Journal Article

Identification and characterization of glyceraldehyde 3-phosphate dehydrogenase from Fasciola gigantica

by Chetri, Purna B Shukla, Rohit Tripathi, Timir Published in Parasitology research (1987) (31.01.2019)

“...Fasciola gigantica is an important food-borne trematode responsible for the hepatobiliary disease, commonly known as fascioliasis. In F. gigantica, the...”

Journal Article

Targeting Nucleotide Binding Domain of Multidrug Resistance-associated Protein-1 (MRP1) for the Reversal of Multi Drug Resistance in Cancer

by Dhasmana, Divya Singh, Ashutosh Shukla, Rohit Tripathi, Timir Garg, Neha Published in Scientific reports (10.08.2018)

“...Multidrug resistance (MDR) is the major cause, by which cancer cells expel the drugs out, developing a challenge against the current chemotherapeutic drugs...”

Journal Article

Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica

by Kalita, Jupitara Shukla, Rohit Shukla, Harish Gadhave, Kundlik Giri, Rajanish Tripathi, Timir Published in Scientific reports (13.12.2017)

“...Glutathione S‒transferases (GSTs) play an important role in the detoxification of xenobiotics. They catalyze the nucleophilic addition of glutathione (GSH) to...”

Journal Article

Alternate pathway to ascorbate induced inhibition of Mycobacterium tuberculosis

by Shukla, Harish Khan, Shaheb Raj Shukla, Rohit Krishnan, Manju Yasoda Akhtar, Md. Sohail Tripathi, Timir Published in Tuberculosis (Edinburgh, Scotland) (01.07.2018)

“...Ascorbate has been demonstrated to interfere with the growth of Mycobacterium tuberculosis. It scavenges oxygen in the culture medium to induce dormancy of M...”

Journal Article

Intrinsically Disordered Human T Lymphotropic Virus Type 1 p30 Protein: Experimental and Computational Evidence

by Namdev, Priyanka Lyngdoh, Denzelle Lee Dar, Hamid Y Chaurasiya, Shivendra K Srivastava, Rupesh Tripathi, Timir Anupam, Rajaneesh Published in AIDS research and human retroviruses (01.05.2019)

“...Human T lymphotropic virus type 1 (HTLV-1) causes adult T cell leukemia and lymphoma and other neuroinflammatory diseases. The pX region of HTLV-1 genome...”

Journal Article

High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: implications for potential resistance

by Padhi, Aditya K Shukla, Rohit Saudagar, Prakash Tripathi, Timir Published in iScience (22.01.2021)

“...The use of remdesivir to treat COVID-19 will likely continue before clinical trials are completed. Due to the lengthening pandemic and evolving nature of the...”

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Journal Article

An efficient protocol to enhance recombinant protein expression using ethanol in Escherichia coli

by Chhetri, Gaurav Kalita, Parismita Tripathi, Timir Published in MethodsX (2015)

“...Bacterial cells can be engineered to express non-native genes, resulting in the production of, recombinant proteins, which have various biotechnological and...”

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Journal Article

Eucalyptol, sabinene and cinnamaldehyde: potent inhibitors of salmonella target protein l-asparaginase

by Vimal, Archana Pal, Dharm Tripathi, Timir Kumar, Awanish Published in 3 Biotech (01.08.2017)

“...Salmonella typhimurium is a severe threat to human life. The treatment became more difficult with the emergence of multidrug resistance. In the present in...”

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Journal Article

Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase

by Chaluveelaveedu Murleedharan Nisha Ashwini Kumar Prateek Nair Nityasha Gupta Chitrangda Silakari Timir Tripathi Awanish Kumar
edited by Hong, Huixiao
Published in Advances in bioinformatics (01.12.2016)

“...Amyloidogenic pathway in Alzheimer’s disease (AD) involves breakdown of APP by β-secretase followed by γ-secretase and results in formation of amyloid beta...”

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Journal Article

The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II

by Bharati, Akhilendra Pratap Singh, Neha Kumar, Vikash Kashif, Md Singh, Amit Kumar Singh, Priyanka Singh, Sudhir Kumar Siddiqi, Mohammad Imran Tripathi, Timir Akhtar, Md Sohail Published in Scientific reports (09.08.2016)

“...RNA Polymerase II (RNAPII) uniquely possesses an extended carboxy terminal domain (CTD) on its largest subunit, Rpb1, comprising a repetitive Tyr1Ser2Pro3Thr4...”

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