Search Results - "Wadsworth, Jonathan"

Journal Article

Evidence for human transmission of amyloid-beta pathology and cerebral amyloid angiopathy

by Jaunmuktane, Zane Mead, Simon Ellis, Matthew Wadsworth, Jonathan D F Nicoll, Andrew J Kenny, Joanna Launchbury, Francesca Linehan, Jacqueline Richard-Loendt, Angela Walker, A Sarah Rudge, Peter Collinge, John Brandner, Sebastian Published in Nature (London) (10.09.2015)

“...More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment, typically in childhood, with human cadaveric...”

Journal Article

Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin

by Cronier, Sabrina Gros, Nathalie Tattum, M Howard Jackson, Graham S Clarke, Anthony R Collinge, John Wadsworth, Jonathan D F Published in Biochemical journal (01.12.2008)

“...Disease-related PrP(Sc) [pathogenic PrP (prion protein)] is classically distinguished from its normal cellular precursor, PrP(C)(cellular PrP) by its detergent...”

Journal Article

Variant Creutzfeldt–Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129

by Joiner, Susan Jaunmuktane, Zane Mok, Tzehow Morgan, Catherine Rudge, Peter Wakerley, Benjamin Mead, Simon Campbell, Tracy Jäger, H. Rolf Golestani, Farhad Wadsworth, Jonathan D.F Brandner, Sebastian Collinge, John Published in The New England journal of medicine (19.01.2017)

“...In this case study, variant Creutzfeldt–Jakob disease (CJD) is shown to occur in a young man with heterozygosity, rather than homozygosity, at codon 129 of the...”

Journal Article

Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report

by Wroe, Stephen J Pal, Suvankar Siddique, Durrenajaf Hyare, Harpreet Macfarlane, Rebecca Joiner, Susan Linehan, Jacqueline M Brandner, Sebastian Wadsworth, Jonathan DF Hewitt, Patricia Collinge, John Published in The Lancet (British edition) (2006)

“...Concerns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible by blood transfusion. Two cases of prion infection in a group of...”

Journal Article

Molecular pathology of human prion disease

by Wadsworth, Jonathan D. F Wadsworth, Jonathan D. F Collinge, John Collinge, John Published in Acta neuropathologica (01.01.2011)

“...Human prion diseases are associated with a range of clinical presentations and are classified by both clinicopathological syndrome and aetiology with...”

Fulltext

eBook

Labour markets in the time of coronavirus: measuring excess

by Wadsworth, Jonathan
01.07.2020

“...No matter the cause, recessions are usually accompanied by some combination of job loss, hiring freezes, wage cuts or hours reductions. In a rapidly evolving...”

Fulltext

Journal Article

A naturally occurring variant of the human prion protein completely prevents prion disease

by Asante, Emmanuel A Smidak, Michelle Grimshaw, Andrew Houghton, Richard Tomlinson, Andrew Jeelani, Asif Jakubcova, Tatiana Hamdan, Shyma Richard-Londt, Angela Linehan, Jacqueline M Brandner, Sebastian Alpers, Michael Whitfield, Jerome Mead, Simon Wadsworth, Jonathan D F Collinge, John Published in Nature (London) (25.06.2015)

“...Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded cellular prion protein (PrP). A novel...”

Journal Article

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

by Terry, Cassandra Harniman, Robert L Sells, Jessica Wenborn, Adam Joiner, Susan Saibil, Helen R Miles, Mervyn J Collinge, John Wadsworth, Jonathan D F Published in Scientific reports (23.01.2019)

“...Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative...”

Fulltext

Journal Article

Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years

by Rudge, Peter Jaunmuktane, Zane Adlard, Peter Bjurstrom, Nina Caine, Diana Lowe, Jessica Norsworthy, Penny Hummerich, Holger Druyeh, Ron Wadsworth, Jonathan D F Brandner, Sebastian Hyare, Harpreet Mead, Simon Collinge, John Published in Brain (London, England : 1878) (01.11.2015)

“...Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced growth hormone during childhood are still being seen in the UK 30...”

Journal Article

Unemployment and Domestic Violence: Theory and Evidence

by Anderberg, Dan Rainer, Helmut Wadsworth, Jonathan Wilson, Tanya Published in The Economic journal (London) (01.11.2016)

“...Does rising unemployment really increase domestic violence as many commentators expect? The contribution of this article is to examine how changes in...”

Fulltext

Journal Article

Mustn't Grumble: Immigration, Health and Health Service Use in the UK and Germany

by Jonathan Wadsworth Published in Fiscal studies (01.03.2013)

“...A rise in population caused by increased immigration is sometimes accompanied by concerns that the increase in population puts additional or differential...”

Journal Article

Recent Advances in Understanding Mammalian Prion Structure: A Mini Review

by Terry, Cassandra Wadsworth, Jonathan D F Published in Frontiers in molecular neuroscience (2019-00-00)

“...Prions are lethal pathogens, which cause fatal neurodegenerative diseases in mammals. They are unique infectious agents and are composed of self-propagating...”

Fulltext

Journal Article

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

by Sandberg, Malin K Al-Doujaily, Huda Sharps, Bernadette De Oliveira, Michael Wiggins Schmidt, Christian Richard-Londt, Angela Lyall, Sarah Linehan, Jacqueline M Brandner, Sebastian Wadsworth, Jonathan D F Clarke, Anthony R Collinge, John Published in Nature communications (09.07.2014)

“...Prions are lethal infectious agents thought to consist of multi-chain forms (PrP(Sc)) of misfolded cellular prion protein (PrP(C)). Prion propagation proceeds...”

Journal Article

The Impact of Acquiring Unrestricted Work Authorization on Romanian and Bulgarian Migrants in the United Kingdom

by Ruhs, Martin Wadsworth, Jonathan Published in Industrial & labor relations review (01.08.2018)

“...When Romania and Bulgaria (the so-called A2 countries) joined the European Union in 2007, the United Kingdom imposed temporary restrictions on the employment...”

Journal Article

Off EU Go? Brexit, the UK Labour Market and Immigration

by Wadsworth, Jonathan Published in Fiscal studies (01.12.2018)

“...Immigration remains a highly antagonistic issue and its purported effects in the labour market are still contestable. Against this background, the UK looks set...”

Journal Article

A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy

by Mead, Simon Gandhi, Sonia Beck, Jon Caine, Diana Gallujipali, Dillip Carswell, Christopher Hyare, Harpreet Joiner, Susan Ayling, Hilary Lashley, Tammaryn Linehan, Jacqueline M Al-Doujaily, Huda Sharps, Bernadette Revesz, Tamas Sandberg, Malin K Reilly, Mary M Koltzenburg, Martin Forbes, Alastair Rudge, Peter Brandner, Sebastian Warren, Jason D Wadsworth, Jonathan D.F Wood, Nicholas W Holton, Janice L Collinge, John Published in The New England journal of medicine (14.11.2013)

“...Prions cause a variety of CNS illnesses, such as Creutzfeldt–Jakob disease. In this British kindred, a prion-associated process was associated with chronic...”

Journal Article

Amyloid-beta nanotubes are associated with prion protein-dependent synaptotoxicity

by Nicoll, Andrew J Panico, Silvia Freir, Darragh B Wright, Daniel Terry, Cassandra Risse, Emmanuel Herron, Caroline E O'Malley, Tiernan Wadsworth, Jonathan D F Farrow, Mark A Walsh, Dominic M Saibil, Helen R Collinge, John Published in Nature communications (2013-00-00)

“...Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer's disease with toxicities mimicked by...”

Journal Article

Human Prion Protein with Valine 129 Prevents Expression of Variant CJD Phenotype

by Wadsworth, Jonathan D. F Asante, Emmanuel A Desbruslais, Melanie Linehan, Jacqueline M Joiner, Susan Gowland, Ian Welch, Julie Stone, Lisa Lloyd, Sarah E Hill, Andrew F Brandner, Sebastian Collinge, John Published in Science (03.12.2004)

“...Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly distinctive clinicopathological and molecular phenotype of human prion disease associated with...”

Fulltext

Journal Article

Update on human prion disease

by Wadsworth, Jonathan D.F Collinge, John Published in Biochimica et biophysica acta. Molecular basis of disease (2007)

“...The recognition that variant Creutzfeldt–Jakob disease (vCJD) is caused by the same prion strain as bovine spongiform encephalopathy in cattle has dramatically...”

Fulltext

Journal Article

by Mark Kristiansen Marcus J. Messenger Peter-Christian KlÃ¶hn Sebastian Brandner Jonathan D. F. Wadsworth John Collinge Sarah J. Tabrizi Published in The Journal of biological chemistry (18.11.2005)

“...The molecular basis for neuronal death in prion disease is not established, but putative pathogenic roles for both disease-related prion protein (PrP Sc ) and...”

1
2
3
4
5
6
7
8
9
10
11
Next »
[30]

Narrow search