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  • Your search results: "Wadsworth, Jonathan"
Showing 1 - 20 results of 584 for search '"Wadsworth, Jonathan"', query time: 1.67s Narrow search
  • 1
    Cover Image Journal Article
    Evidence for human transmission of amyloid-beta pathology and cerebral amyloid angiopathy
    by Jaunmuktane, Zane   Mead, Simon   Ellis, Matthew   Wadsworth, Jonathan D F   Nicoll, Andrew J   Kenny, Joanna   Launchbury, Francesca   Linehan, Jacqueline   Richard-Loendt, Angela   Walker, A Sarah   Rudge, Peter   Collinge, John   Brandner, Sebastian Published in Nature (London) (10.09.2015)
    “...More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment, typically in childhood, with human cadaveric...”
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  • 2
    Cover Image Journal Article
    Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin
    by Cronier, Sabrina   Gros, Nathalie   Tattum, M Howard   Jackson, Graham S   Clarke, Anthony R   Collinge, John   Wadsworth, Jonathan D F Published in Biochemical journal (01.12.2008)
    “...Disease-related PrP(Sc) [pathogenic PrP (prion protein)] is classically distinguished from its normal cellular precursor, PrP(C)(cellular PrP) by its detergent...”
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  • 3
    Cover Image Journal Article
    Variant Creutzfeldt–Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129
    by Joiner, Susan   Jaunmuktane, Zane   Mok, Tzehow   Morgan, Catherine   Rudge, Peter   Wakerley, Benjamin   Mead, Simon   Campbell, Tracy   Jäger, H. Rolf   Golestani, Farhad   Wadsworth, Jonathan D.F   Brandner, Sebastian   Collinge, John Published in The New England journal of medicine (19.01.2017)
    “...In this case study, variant Creutzfeldt–Jakob disease (CJD) is shown to occur in a young man with heterozygosity, rather than homozygosity, at codon 129 of the...”
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  • 4
    Cover Image Journal Article
    Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report
    by Wroe, Stephen J   Pal, Suvankar   Siddique, Durrenajaf   Hyare, Harpreet   Macfarlane, Rebecca   Joiner, Susan   Linehan, Jacqueline M   Brandner, Sebastian   Wadsworth, Jonathan DF   Hewitt, Patricia   Collinge, John Published in The Lancet (British edition) (2006)
    “...Concerns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible by blood transfusion. Two cases of prion infection in a group of...”
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  • 5
    Cover Image Journal Article
    Molecular pathology of human prion disease
    by Wadsworth, Jonathan D. F   Wadsworth, Jonathan D. F   Collinge, John   Collinge, John Published in Acta neuropathologica (01.01.2011)
    “...Human prion diseases are associated with a range of clinical presentations and are classified by both clinicopathological syndrome and aetiology with...”
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  • 6
    Cover Image eBook
    Labour markets in the time of coronavirus: measuring excess
    by Wadsworth, Jonathan
    01.07.2020
    “...No matter the cause, recessions are usually accompanied by some combination of job loss, hiring freezes, wage cuts or hours reductions. In a rapidly evolving...”
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  • 7
    Cover Image Journal Article
    A naturally occurring variant of the human prion protein completely prevents prion disease
    by Asante, Emmanuel A   Smidak, Michelle   Grimshaw, Andrew   Houghton, Richard   Tomlinson, Andrew   Jeelani, Asif   Jakubcova, Tatiana   Hamdan, Shyma   Richard-Londt, Angela   Linehan, Jacqueline M   Brandner, Sebastian   Alpers, Michael   Whitfield, Jerome   Mead, Simon   Wadsworth, Jonathan D F   Collinge, John Published in Nature (London) (25.06.2015)
    “...Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded cellular prion protein (PrP). A novel...”
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  • 8
    Cover Image Journal Article
    Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro
    by Terry, Cassandra   Harniman, Robert L   Sells, Jessica   Wenborn, Adam   Joiner, Susan   Saibil, Helen R   Miles, Mervyn J   Collinge, John   Wadsworth, Jonathan D F Published in Scientific reports (23.01.2019)
    “...Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative...”
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  • 9
    Cover Image Journal Article
    Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years
    by Rudge, Peter   Jaunmuktane, Zane   Adlard, Peter   Bjurstrom, Nina   Caine, Diana   Lowe, Jessica   Norsworthy, Penny   Hummerich, Holger   Druyeh, Ron   Wadsworth, Jonathan D F   Brandner, Sebastian   Hyare, Harpreet   Mead, Simon   Collinge, John Published in Brain (London, England : 1878) (01.11.2015)
    “...Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced growth hormone during childhood are still being seen in the UK 30...”
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  • 10
    Cover Image Journal Article
    Unemployment and Domestic Violence: Theory and Evidence
    by Anderberg, Dan   Rainer, Helmut   Wadsworth, Jonathan   Wilson, Tanya Published in The Economic journal (London) (01.11.2016)
    “...Does rising unemployment really increase domestic violence as many commentators expect? The contribution of this article is to examine how changes in...”
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  • 11
    Cover Image Journal Article
    Mustn't Grumble: Immigration, Health and Health Service Use in the UK and Germany
    by Jonathan Wadsworth Published in Fiscal studies (01.03.2013)
    “...A rise in population caused by increased immigration is sometimes accompanied by concerns that the increase in population puts additional or differential...”
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  • 12
    Cover Image Journal Article
    Recent Advances in Understanding Mammalian Prion Structure: A Mini Review
    by Terry, Cassandra   Wadsworth, Jonathan D F Published in Frontiers in molecular neuroscience (2019-00-00)
    “...Prions are lethal pathogens, which cause fatal neurodegenerative diseases in mammals. They are unique infectious agents and are composed of self-propagating...”
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  • 13
    Cover Image Journal Article
    Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked
    by Sandberg, Malin K   Al-Doujaily, Huda   Sharps, Bernadette   De Oliveira, Michael Wiggins   Schmidt, Christian   Richard-Londt, Angela   Lyall, Sarah   Linehan, Jacqueline M   Brandner, Sebastian   Wadsworth, Jonathan D F   Clarke, Anthony R   Collinge, John Published in Nature communications (09.07.2014)
    “...Prions are lethal infectious agents thought to consist of multi-chain forms (PrP(Sc)) of misfolded cellular prion protein (PrP(C)). Prion propagation proceeds...”
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  • 14
    Cover Image Journal Article
    The Impact of Acquiring Unrestricted Work Authorization on Romanian and Bulgarian Migrants in the United Kingdom
    by Ruhs, Martin   Wadsworth, Jonathan Published in Industrial & labor relations review (01.08.2018)
    “...When Romania and Bulgaria (the so-called A2 countries) joined the European Union in 2007, the United Kingdom imposed temporary restrictions on the employment...”
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  • 15
    Cover Image Journal Article
    Off EU Go? Brexit, the UK Labour Market and Immigration
    by Wadsworth, Jonathan Published in Fiscal studies (01.12.2018)
    “...Immigration remains a highly antagonistic issue and its purported effects in the labour market are still contestable. Against this background, the UK looks set...”
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  • 16
    Cover Image Journal Article
    A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy
    by Mead, Simon   Gandhi, Sonia   Beck, Jon   Caine, Diana   Gallujipali, Dillip   Carswell, Christopher   Hyare, Harpreet   Joiner, Susan   Ayling, Hilary   Lashley, Tammaryn   Linehan, Jacqueline M   Al-Doujaily, Huda   Sharps, Bernadette   Revesz, Tamas   Sandberg, Malin K   Reilly, Mary M   Koltzenburg, Martin   Forbes, Alastair   Rudge, Peter   Brandner, Sebastian   Warren, Jason D   Wadsworth, Jonathan D.F   Wood, Nicholas W   Holton, Janice L   Collinge, John Published in The New England journal of medicine (14.11.2013)
    “...Prions cause a variety of CNS illnesses, such as Creutzfeldt–Jakob disease. In this British kindred, a prion-associated process was associated with chronic...”
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  • 17
    Cover Image Journal Article
    Amyloid-beta nanotubes are associated with prion protein-dependent synaptotoxicity
    by Nicoll, Andrew J   Panico, Silvia   Freir, Darragh B   Wright, Daniel   Terry, Cassandra   Risse, Emmanuel   Herron, Caroline E   O'Malley, Tiernan   Wadsworth, Jonathan D F   Farrow, Mark A   Walsh, Dominic M   Saibil, Helen R   Collinge, John Published in Nature communications (2013-00-00)
    “...Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer's disease with toxicities mimicked by...”
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  • 18
    Cover Image Journal Article
    Human Prion Protein with Valine 129 Prevents Expression of Variant CJD Phenotype
    by Wadsworth, Jonathan D. F   Asante, Emmanuel A   Desbruslais, Melanie   Linehan, Jacqueline M   Joiner, Susan   Gowland, Ian   Welch, Julie   Stone, Lisa   Lloyd, Sarah E   Hill, Andrew F   Brandner, Sebastian   Collinge, John Published in Science (03.12.2004)
    “...Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly distinctive clinicopathological and molecular phenotype of human prion disease associated with...”
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  • 19
    Cover Image Journal Article
    Update on human prion disease
    by Wadsworth, Jonathan D.F   Collinge, John Published in Biochimica et biophysica acta. Molecular basis of disease (2007)
    “...The recognition that variant Creutzfeldt–Jakob disease (vCJD) is caused by the same prion strain as bovine spongiform encephalopathy in cattle has dramatically...”
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  • 20
    Cover Image Journal Article
    Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis
    by Mark Kristiansen   Marcus J. Messenger   Peter-Christian Klöhn   Sebastian Brandner   Jonathan D. F. Wadsworth   John Collinge   Sarah J. Tabrizi Published in The Journal of biological chemistry (18.11.2005)
    “...The molecular basis for neuronal death in prion disease is not established, but putative pathogenic roles for both disease-related prion protein (PrP Sc ) and...”
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