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  • Your search results: "Wijesekara, Nadeeja"
Showing 1 - 20 results of 44 for search '"Wijesekara, Nadeeja"', query time: 1.96s Narrow search
  • 1
    Cover Image Journal Article
    The link between type 2 diabetes and neurodegeneration: Roles for amyloid-beta, amylin, and tau proteins
    by Bharadwaj, Prashant   Wijesekara, Nadeeja   Liyanapathirana, Milindu   Newsholme, Philip   Ittner, Lars   Fraser, Paul   Verdile, Giuseppe Published in Journal of Alzheimer's disease (2017-00-00)
    “...A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and neurodegenerative diseases such as Alzheimer's disease (AD). Although the...”
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  • 2
    Cover Image Journal Article
    Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease
    by Giuseppe Verdile   Kevin N. Keane   Vinicius F. Cruzat   Sandra Medic   Miheer Sabale   Joanne Rowles   Nadeeja Wijesekara   Ralph N. Martins   Paul E. Fraser   Philip Newsholme
    edited by Macciò, Antonio
    Published in Mediators of inflammation (01.12.2015)
    “...Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent...”
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  • 3
    Cover Image Journal Article
    Amyloid‐β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model
    by Wijesekara, Nadeeja   Ahrens, Rosemary   Sabale, Miheer   Wu, Ling   Ha, Kathy   Verdile, Giuseppe   Fraser, Paul E Published in The FASEB journal (01.12.2017)
    “...ABSTRACT Alzheimer’s disease (AD) and type 2 diabetes (T2D) present a significant risk to each other. AD and T2D are characterized by deposition of cerebral...”
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  • 4
    Cover Image Journal Article
    Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1
    by Kaur, Achint   Patankar, Jay V   de Haan, Willeke   Ruddle, Piers   Wijesekara, Nadeeja   Groen, Albert K   Verchere, C. Bruce   Singaraja, Roshni R   Hayden, Michael R Published in Diabetes (New York, N.Y.) (01.04.2015)
    “...Besides their role in facilitating lipid absorption, bile acids are increasingly being recognized as signaling molecules that activate cell-signaling...”
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  • 5
    Cover Image Journal Article
    Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
    by Tamara J. Nicolson   Elisa A. Bellomo   Nadeeja Wijesekara   Merewyn K. Loder   Jocelyn M. Baldwin   Armen V. Gyulkhandanyan   Vasilij Koshkin   Andrei I. Tarasov   Raffaella Carzaniga   Katrin Kronenberger   Tarvinder K. Taneja   Gabriela da Silva Xavier   Sarah Libert   Philippe Froguel   Raphael Scharfmann   Volodymir Stetsyuk   Philippe Ravassard   Helen Parker   Fiona M. Gribble   Frank Reimann   Robert Sladek   Stephen J. Hughes   Paul R.V. Johnson   Myriam Masseboeuf   Remy Burcelin   Stephen A. Baldwin   Ming Liu   Roberto Lara-Lemus   Peter Arvan   Frans C. Schuit   Michael B. Wheeler   Fabrice Chimienti   Guy A. Rutter Published in Diabetes (New York, N.Y.) (01.09.2009)
    “...Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants Tamara J...”
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  • 6
    Cover Image Journal Article
    The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies
    by Gonçalves, Rafaella Araujo   Wijesekara, Nadeeja   Fraser, Paul E   De Felice, Fernanda G Published in Frontiers in cellular neuroscience (2019-00-00)
    “...The microtubule-associated protein tau (MAPT) is mainly identified as a tubulin binding protein essential for microtubule dynamics and assembly and for neurite...”
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  • 7
    Cover Image Journal Article
    ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice
    by Wijesekara, Nadeeja   Kaur, Achint   Westwell-Roper, Clara   Nackiewicz, Dominika   Soukhatcheva, Galina   Hayden, Michael R   Verchere, C Bruce Published in Diabetologia (01.06.2016)
    “...Islet amyloid, a pathological feature of type 2 diabetes, forms from the aggregation of islet amyloid polypeptide (IAPP), a beta cell peptide that is produced...”
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  • 8
    Cover Image Journal Article
    Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK
    by Nadeeja Wijesekara   Amanda Tung   Farah Thong   Amira Klip Published in American Journal of Physiology - Endocrinology And Metabolism (01.06.2006)
    “...Contracting skeletal muscle increases glucose uptake to sustain energy demand. This is achieved through a gain in GLUT4 at the membrane, but the traffic...”
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  • 9
    Cover Image Journal Article
    Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
    by Laws, Simon M   Gaskin, Scott   Woodfield, Amy   Srikanth, Velandai   Bruce, David   Fraser, Paul E   Porter, Tenielle   Newsholme, Philip   Wijesekara, Nadeeja   Burnham, Samantha   Doré, Vincent   Li, Qiao-Xin   Maruff, Paul   Masters, Colin L   Rainey-Smith, Stephanie   Rowe, Christopher C   Salvado, Olivier   Villemagne, Victor L   Martins, Ralph N   Verdile, Giuseppe Published in Scientific reports (29.08.2017)
    “...Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models...”
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  • 10
    Cover Image Journal Article
    Behavioral Abnormalities in Knockout and Humanized Tau Mice
    by Gonçalves, Rafaella Araujo   Wijesekara, Nadeeja   Fraser, Paul E   De Felice, Fernanda G Published in Frontiers in endocrinology (Lausanne) (2020-00-00)
    “...Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance...”
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  • 11
    Cover Image Journal Article
    Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes
    by Nadeeja Wijesekara   Daniel Konrad   Mohamed Eweida   Craig Jefferies   Nicole Liadis   Adria Giacca   Mike Crackower   Akira Suzuki   Tak W. Mak   C. Ronald Kahn   Amira Klip   Minna Woo Published in Molecular and Cellular Biology (01.02.2005)
    “...Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...”
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  • 12
    Cover Image Journal Article
    Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function
    by Kruit, Janine K   Wijesekara, Nadeeja   Westwell-Roper, Clara   Vanmierlo, Tim   de Haan, Willeke   Bhattacharjee, Alpana   Tang, Renmei   Wellington, Cheryl L   LutJohann, Dieter   Johnson, James D   Brunham, Liam R   Verchere, C. Bruce   Hayden, Michael R Published in Diabetes (New York, N.Y.) (01.03.2012)
    “...Cellular cholesterol homeostasis is important for normal [beta]-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding...”
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  • 13
    Cover Image Journal Article
    The Identification of Potential Factors Associated with the Development of Type 2 Diabetes
    by Hongfang Lu   Ying Yang   Emma M. Allister   Nadeeja Wijesekara   Michael B. Wheeler Published in Molecular & cellular proteomics (01.08.2008)
    “...Type 2 diabetes (T2D) arises when pancreatic β-cells fail to compensate for systemic insulin resistance with appropriate insulin secretion. However, the link...”
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  • 14
    Cover Image Journal Article
    Impaired peripheral glucose homeostasis and Alzheimer's disease
    by Wijesekara, Nadeeja   Gonçalves, Rafaella Araujo   De Felice, Fernanda G   Fraser, Paul E Published in Neuropharmacology (01.07.2018)
    “...Alzheimer's disease (AD) is the most common type of dementia. Recent studies suggest that metabolic disturbances, particularly type 2 diabetes (T2D) increase...”
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  • 15
    Cover Image Journal Article
    Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion
    by Wijesekara, Nadeeja   Krishnamurthy, Mansa   Bhattacharjee, Alpana   Suhail, Aamir   Sweeney, Gary   Wheeler, Michael B Published in The Journal of biological chemistry (29.10.2010)
    “...The functional impact of adiponectin on pancreatic beta cells is so far poorly understood. Although adiponectin receptors (AdipoR1/2) were identified, their...”
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  • 16
    Cover Image Journal Article
    The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach
    by Lu, Hongfang   Yang, Ying   Allister, Emma M   Wijesekara, Nadeeja   Wheeler, Michael B Published in Molecular & cellular proteomics (01.08.2008)
    “...Type 2 diabetes (T2D) arises when pancreatic beta-cells fail to compensate for systemic insulin resistance with appropriate insulin secretion. However, the...”
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  • 17
    Cover Image Journal Article
    Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance
    by Wijesekara, Nadeeja   Gonçalves, Rafaella Araujo   Ahrens, Rosemary   De Felice, Fernanda G   Fraser, Paul E Published in The FASEB journal (01.06.2018)
    “...ABSTRACT The microtubule‐associated protein tau is highly expressed in pancreatic islets. Abnormally phosphorylated tau aggregates assemble into...”
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  • 18
    Cover Image Journal Article
    Regulation of ABCA1 Protein Expression and Function in Hepatic and Pancreatic Islet Cells by miR-145
    by Kang, Martin H   Zhang, Lin-Hua   Wijesekara, Nadeeja   de Haan, Willeke   Butland, Stefanie   Bhattacharjee, Alpana   Hayden, Michael R Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2013)
    “...OBJECTIVE—The ATP-binding cassette transporter A1 (ABCA1) protein maintains cellular cholesterol homeostasis in several different tissues. In the liver, ABCA1...”
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  • 19
    Cover Image Journal Article
    miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets
    by WIJESEKARA, Nadeeja   ZHANG, Lin-Hua   KANG, Martin H   ABRAHAM, Thomas   BHATTACHARJEE, Alpana   WARNOCK, Garth L   VERCHERE, C. Bruce   HAYDEN, Michael R Published in Diabetes (New York, N.Y.) (2012)
    “...Changes in cellular cholesterol affect insulin secretion, and β-cell-specific deletion or loss-of-function mutations in the cholesterol efflux transporter...”
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  • 20
    Cover Image Journal Article
    Multiple factors contribute to obesity among Kuwaiti college women
    by Abdulwahab Naser Al-Isa   Nadeeja Wijesekara   Ediriweera Desapriya Published in Health (Irvine, Calif.) (01.05.2013)
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