Search Results - "cancer driver genes"

Journal Article

The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity

by Laneve, Pietro Po, Agnese Favia, Annarita Legnini, Ivano Alfano, Vincenzo Rea, Jessica Di Carlo, Valerio Bevilacqua, Valeria Miele, Evelina Mastronuzzi, Angela Carai, Andrea Locatelli, Franco Bozzoni, Irene Ferretti, Elisabetta Caffarelli, Elisa Published in Oncotarget (09.05.2017)

“...Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system...”

Journal Article

Not all cancers are created equal: Tissue specificity in cancer genes and pathways

by Bianchi, Joy J Zhao, Xin Mays, Joseph C Davoli, Teresa Published in Current opinion in cell biology (01.04.2020)

“...Tumors arise through waves of genetic alterations and clonal expansion that allow tumor cells to acquire cancer hallmarks, such as genome instability and...”

Journal Article

Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma

by Molina-Sánchez, Pedro Ruiz de Galarreta, Marina Yao, Melissa A Lindblad, Katherine E Bresnahan, Erin Bitterman, Elizabeth Martin, Tiphaine C Rubenstein, Troy Nie, Kai Golas, Jonathan Choudhary, Shambhunath Bárcena-Varela, Marina Elmas, Abdulkadir Miguela, Veronica Ding, Ying Kan, Zhengyan Grinspan, Lauren Tal Huang, Kuan-Lin Parsons, Ramon E Shields, David J Rollins, Robert A Lujambio, Amaia Published in Gastroenterology (New York, N.Y. 1943) (01.12.2020)

“...The pattern of genetic alterations in cancer driver genes in patients with hepatocellular carcinoma (HCC) is highly diverse, which partially explains the low...”

Journal Article

Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes

by Cheng, Feixiong Zhao, Junfei Zhao, Zhongming Published in Briefings in bioinformatics (01.07.2016)

“...Cancer is often driven by the accumulation of genetic alterations, including single nucleotide variants, small insertions or deletions, gene fusions,...”

Journal Article

Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival

by Roessler, Stephanie Long, Ezhou Lori Budhu, Anuradha Chen, Yidong Zhao, Xuelian Ji, Junfang Walker, Robert Jia, Hu–Liang Ye, Qing–Hai Qin, Lun–Xiu Tang, Zhao–You He, Ping Hunter, Kent W Thorgeirsson, Snorri S Meltzer, Paul S Wang, Xin Wei Published in Gastroenterology (New York, N.Y. 1943) (2012)

“...Background & Aims Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an...”

Journal Article

MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study

by Wang, Lili Hu, Shasha Xin, Fangjie Zhao, Han Li, Guangqi Ran, Wenwen Xing, Xiaoming Wang, Jigang Published in Human pathology (01.05.2020)

“...Intravenous leiomyomatosis (IVL) is a rare neoplasm that is characterized by smooth muscle cell proliferation within venous vessels. The aim of this study is...”

Journal Article

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retrovira...

by Glinsky, Gennadi V Published in Frontiers in oncology (31.03.2021)

“...Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary...”

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Journal Article

Genomic analysis of low‐grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities

by Cheasley, Dane Nigam, Abhimanyu Zethoven, Magnus Hunter, Sally Etemadmoghadam, Dariush Semple, Timothy Allan, Prue Carey, Mark S Fernandez, Marta L Dawson, Amy Köbel, Martin Huntsman, David G Le Page, Cécile Mes‐Masson, Anne‐Marie Provencher, Diane Hacker, Neville Gao, Yunkai Bowtell, David deFazio, Anna Gorringe, Kylie L Campbell, Ian G Published in The Journal of pathology (01.01.2021)

“...Low‐grade serous ovarian carcinoma (LGSOC) is associated with a poor response to existing chemotherapy, highlighting the need to perform comprehensive genomic...”

Journal Article

Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression

by Lasorsa, Vito Alessandro Formicola, Daniela Pignataro, Piero Cimmino, Flora Calabrese, Francesco Maria Mora, Jaume Esposito, Maria Rosaria Pantile, Marcella Zanon, Carlo De Mariano, Marilena Longo, Luca Hogarty, Michael D de Torres, Carmen Tonini, Gian Paolo Iolascon, Achille Capasso, Mario Published in Oncotarget (19.04.2016)

“...The spectrum of somatic mutation of the most aggressive forms of neuroblastoma is not completely determined. We sought to identify potential cancer drivers in...”

Journal Article

Interaction analysis between germline susceptibility loci and somatic alterations in lung cancer

by Wang, Yuzhuo Wang, Cheng Zhang, Jiahui Zhu, Meng Zhang, Xu Li, Zhihua Dai, Juncheng Ma, Hongxia Hu, Zhibin Jin, Guangfu Shen, Hongbing Published in International journal of cancer (15.08.2018)

“...Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. However, the germline–somatic interaction in lung...”

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Journal Article

Characterization of potential driver mutations involved in human breast cancer by computational approaches

by Rajendran, Barani Kumar Deng, Chu-Xia Published in Oncotarget (25.07.2017)

“...Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of...”

Journal Article

Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers

by Chen, Zhishan Wen, Wanqing Beeghly-Fadiel, Alicia Shu, Xiao-ou Díez-Obrero, Virginia Long, Jirong Bao, Jiandong Wang, Jing Liu, Qi Cai, Qiuyin Moreno, Victor Zheng, Wei Guo, Xingyi Published in American journal of human genetics (05.09.2019)

“...Genome-wide association studies (GWASs) have identified hundreds of genetic risk variants for human cancers. However, target genes for the majority of risk...”

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Journal Article

C3: Consensus Cancer Driver Gene Caller

by Zhu, Chen-Yu Zhou, Chi Chen, Yun-Qin Shen, Ai-Zong Guo, Zong-Ming Yang, Zhao-Yi Ye, Xiang-Yun Qu, Shen Wei, Jia Liu, Qi Published in Genomics, proteomics & bioinformatics (01.06.2019)

“...Next-generation sequencing has allowed identification of millions of somatic mutations in human cancer cells. A key challenge in interpreting cancer genomes is...”

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Journal Article

Pan-cancer detection of driver genes at the single-patient resolution

by Nulsen, Joel Misetic, Hrvoje Yau, Christopher Ciccarelli, Francesca D Published in Genome medicine (01.02.2021)

“...Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify...”

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Journal Article

uKIN Combines New and Prior Information with Guided Network Propagation to Accurately Identify Disease Genes

by Hristov, Borislav H Chazelle, Bernard Singh, Mona Published in Cell systems (24.06.2020)

“...Protein interaction networks provide a powerful framework for identifying genes causal for complex genetic diseases. Here, we introduce a general framework,...”

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Journal Article

Familial and sporadic pancreatic cancer share the same molecular pathogenesis

by Norris, Alexis L Roberts, Nicholas J Jones, Siân Wheelan, Sarah J Papadopoulos, Nickolas Vogelstein, Bert Kinzler, Kenneth W Hruban, Ralph H Klein, Alison P Eshleman, James R Published in Familial cancer (01.03.2015)

“...Pancreatic ductal adenocarcinoma (PDAC) is nearly uniformly lethal, with a median overall survival in 2014 of only 6 months. The genetic progression of...”

Journal Article

Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes

by Przytycki, Pawel F Singh, Mona Published in Genome medicine (25.08.2017)

“...A major aim of cancer genomics is to pinpoint which somatically mutated genes are involved in tumor initiation and progression. We introduce a new framework...”

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Journal Article

Network-Based Coverage of Mutational Profiles Reveals Cancer Genes

by Hristov, Borislav H Singh, Mona Published in Cell systems (27.09.2017)

“...A central goal in cancer genomics is to identify the somatic alterations that underpin tumor initiation and progression. While commonly mutated cancer genes...”

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Journal Article

Using common variants to indicate cancer genes

by Stead, Lucy F Thygesen, Helene Westhead, David R Rabbitts, Pamela Published in International journal of cancer (01.01.2015)

“...The catalogue of tumour‐specific somatic mutations (SMs) is growing rapidly owing to the advent of next‐generation sequencing. Identifying those mutations...”

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Journal Article

TOPDRIVER: the novel identifier of cancer driver genes in Gastric cancer and Melanoma

by Razavi, Seyed Mohammad Rami, Farzaneh Razavi, Seyede Houri Eslahchi, Changiz Published in Applied network science (01.12.2019)

“...Nowadays, research has found a strong relationship between genomic status and occurrence of disease. Cancer is one of the most common diseases that leads to a...”

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