Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chromosome ends. In mammalian cells, Rif1 is not telomeric, but it suppresses DNA end resection at chromosomal breaks, promoting repair by nonhomologous end joining (NHEJ). Here, we describe crystal stru...

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Volume: 24
Main Author: Mattarocci, Stefano
Reinert, Julia K
Bunker, Richard D
Fontana, Gabriele A
Shi, Tianlai
Klein, Dominique
Cavadini, Simone
Faty, Mahamadou
Shyian, Maksym
Hafner, Lukas
Shore, David
Thoma, Nicolas H
Rass, Ulrich
Format: Journal Article
Language: English
Zielgruppe: Academic
Place of publication: NEW YORK NATURE PUBLISHING GROUP 01.07.2017
Nature Publishing Group
published in: Nature structural & molecular biology Vol. 24; no. 7; pp. 588 - 595
ORCID: 0000-0003-4845-2332
0000-0002-9859-143X
0000-0001-6380-627X
0000-0001-9275-9062
Data of publication: 2017-07-01
ISSN: 1545-9993
1545-9985
EISSN: 1545-9985
Discipline: Biology
Subjects:
Online Access: Fulltext
Database: Web of Science - Science Citation Index Expanded - 2017
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