Conformationally Constrained κ Receptor Agonists: Stereoselective Synthesis and Pharmacological Evaluation of 6,8-Diazabicyclo[3.2.2]nonane Derivatives

Three sets of stereoisomeric bicyclic κ agonists with defined orientation of the pharmacophoric elements pyrrolidine and dichlorophenylacetamide were stereoselectively prepared and pharmacologically evaluated. Stereoselective reduction, reductive amination, and Mitsunobu inversions were the key step...

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Bibliographic details
Volume: 53
Main Author: Geiger, Christian
Zelenka, Christel
Lehmkuhl, Kirstin
Schepmann, Dirk
Englberger, Werner
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: United States American Chemical Society 27.05.2010
published in: Journal of medicinal chemistry Vol. 53; no. 10; pp. 4212 - 4222
Data of publication: 20100527
ISSN: 0022-2623
1520-4804
EISSN: 1520-4804
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: Fulltext
Database: Medline
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