Novel σ Receptor Ligands. Part 2. SAR of Spiro[[2]benzopyran-1,4‘-piperidines] and Spiro[[2]benzofuran-1,4‘-piperidines] with Carbon Substituents in Position 3

Several spiro[[2]benzopyran-1,4‘-piperidines] and spiro[[2]benzofuran-1,4‘-piperidines] were synthesized and evaluated for their binding properties for σ1 and σ2 receptors. The key step for the introduction of a one carbon residue is the reaction of the cyclic methyl acetals 2a and 3a with trimethyl...

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Bibliographic details
Volume: 45
Main Author: Maier, Christoph A
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: United States American Chemical Society 24.10.2002
published in: Journal of medicinal chemistry Vol. 45; no. 22; pp. 4923 - 4930
Data of publication: 20021024
ISSN: 0022-2623
1520-4804
EISSN: 1520-4804
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: Fulltext
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