Novel Spiropiperidines as Highly Potent and Subtype Selective σ-Receptor Ligands. Part 1

A series of spiro[[2]benzopyran-1,4‘-piperidines] and spiro[[2]benzofuran-1,4‘-piperidines] of general structure 10 is prepared, and the affinity for σ1- and σ2-receptors is investigated by means of radioligand binding assays. The synthesis of the spiropiperidines 14a and 23 proceeds from bromine/li...

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Bibliographic details
Volume: 45
Main Author: Maier, Christoph A
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: Washington, DC American Chemical Society 17.01.2002
published in: Journal of medicinal chemistry Vol. 45; no. 2; pp. 438 - 448
Data of publication: 20020117
ISSN: 0022-2623
1520-4804
EISSN: 1520-4804
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
Subjects:
Rat
Online Access: Fulltext
CODEN: JMCMAR
Database: Istex
Pascal-Francis
Medline
MEDLINE
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PubMed
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MEDLINE - Academic
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