Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes

The synthesis of novel 1-thio-substituted butadienes, designed as mechanism-based 5-lipoxygenase inhibitors, is described. The structure of these compounds closely resembles a proposed high-energy intermediate during the lipoxygenation of arachidonic acid. They demonstrate 5-lipoxygenase inhibition...

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Bibliographic details
Volume: 33
Main Author: Hanko, Rudolf
Hammond, Michael D
Fruchtmann, Romanis
Pfitzner, Joerg
Place, Graham A
Format: Journal Article
Language: English
Place of publication: Washington, DC American Chemical Society 01.04.1990
published in: Journal of medicinal chemistry Vol. 33; no. 4; pp. 1163 - 1170
Data of publication: 19900401
ISSN: 0022-2623
1520-4804
EISSN: 1520-4804
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: Fulltext
CODEN: JMCMAR
Database: Istex
Pascal-Francis
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