Chiral, nonracemic (piperazin-2-yl)methanol derivatives with σ-receptor affinity

Starting with the proteinogenic amino acid (S)-serine a series of chiral nonracemic (piperazin-2-yl)methanols 3 with various N-4 substituents is described. The key step in the synthesis of 3 is the reaction of the chloroacetamide 5 with various primary amines to yield the diastereomeric bicyclic pip...

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Bibliographic details
Volume: 12
Main Author: BEDURFTIG, S
Format: Journal Article
Language: English
Place of publication: Oxford Elsevier Science 2004
published in: Bioorganic & medicinal chemistry Vol. 12; no. 12; pp. 3299 - 3311
Data of publication: 2004
ISSN: 0968-0896
1464-3391
EISSN: 1464-3391
Discipline: Medicine
Anatomy & Physiology
Chemistry
Subjects:
Rat
Online Access: available in Bonn?
Database: Pascal-Francis
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