(1-Benzylpiperazin-2-yl)methanols: novel EPC synthesis from ( S)-serine and transformation into ligands for central nervous system receptors
A novel three-step synthesis of 4-substituted-(1-benzylpiperazin-2-yl)methanols 5a– 5c is described starting from the methyl ester of the proteinogenic amino acid ( S)-serine, which involves the diastereomeric oxazolidine derivatives 11a– 11c as key intermediates. 5b and 5c were transformed into the...
|Place of publication:||
Elsevier Ltd 2001
|published in:||Tetrahedron: asymmetry Vol. 12; no. 9; pp. 1293 - 1302|
|Data of publication:||2001|
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