(1-Benzylpiperazin-2-yl)methanols: novel EPC synthesis from ( S)-serine and transformation into ligands for central nervous system receptors

A novel three-step synthesis of 4-substituted-(1-benzylpiperazin-2-yl)methanols 5a– 5c is described starting from the methyl ester of the proteinogenic amino acid ( S)-serine, which involves the diastereomeric oxazolidine derivatives 11a– 11c as key intermediates. 5b and 5c were transformed into the...

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Bibliographic details
Volume: 12
Main Author: Bedürftig, Stephan
Weigl, Manuela
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: Elsevier Ltd 2001
published in: Tetrahedron: asymmetry Vol. 12; no. 9; pp. 1293 - 1302
Data of publication: 2001
ISSN: 0957-4166
1362-511X
EISSN: 1362-511X
Discipline: Chemistry
Online Access: Fulltext
Database: CrossRef
Database information Databases - DBIS