Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold

[Display omitted] •Pharmacokinetic properties of three pairs of enantiomers were analyzed.•High performance affinity chromatography led to human serum albumin binding of 76–98 % with low enantioselectivity.•Upon incubation with mouse liver microsomes (R)-configured eutomers showed higher metabolic s...

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Bibliographic details
Volume: 172
Main Author: Börgel, Frederik
Galla, Fabian
Lehmkuhl, Kirstin
Schepmann, Dirk
Ametamey, Simon M
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: AMSTERDAM Elsevier B.V 05.08.2019
ELSEVIER SCIENCE BV
published in: Journal of pharmaceutical and biomedical analysis Vol. 172; pp. 214 - 222
Data of publication: 2019-08-05
ISSN: 0731-7085
1873-264X
EISSN: 1873-264X
Discipline: Pharmacy, Therapeutics, & Pharmacology
Chemistry
Subjects:
Online Access: available in Bonn?
Database: Web of Knowledge
Web of Science - Science Citation Index Expanded - 2019
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