Chiral, nonracemic (piperazin-2-yl)methanol derivatives with σ-receptor affinity

Graphic Starting with the proteinogenic amino acid ( S)-serine a series of chiral nonracemic (piperazin-2-yl)methanols 3 with various N-4 substituents is described. The key step in the synthesis of 3 is the reaction of the chloroacetamide 5 with various primary amines to yield the diastereomeric bic...

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Bibliographic details
Volume: 12
Main Author: Bedurftig, S
Wunsch, B
Format: Journal Article
Language: English
Place of publication: OXFORD Elsevier Ltd 2004
PERGAMON-ELSEVIER SCIENCE LTD
published in: Bioorganic & medicinal chemistry Vol. 12; no. 12; pp. 3299 - 3311
Data of publication: 2004
ISSN: 0968-0896
1464-3391
EISSN: 1464-3391
Discipline: Medicine
Anatomy & Physiology
Chemistry
Subjects:
Online Access: available in Bonn?
Database: Web of Knowledge
Science Citation Index Expanded
Web of Science
Web of Science - Science Citation Index Expanded - 2004
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