Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole

Given our previous finding that fluorination at the C18 position of largazole showed reasonably good tolerance towards inhibitory activity and selectivity of histone deacetylases (HDACs), further modification on the valine residue in the fluoro-largazole's macrocyclic moiety with S-Mel-Cysteine...

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Bibliographic details
Volume: 18
Main Author: Zhang, Bingbing
Ruan, Zhu-Wei
Luo, Dongdong
Zhu, Yueyue
Ding, Tingbo
Sui, Qiang
Lei, Xinsheng
Format: Journal Article
Language: English
Place of publication: BASEL MDPI 01.07.2020
MDPI AG
published in: Marine drugs Vol. 18; no. 7; pp. 344 - 355
Data of publication: 2020-07-01
ISSN: 1660-3397
1660-3397
EISSN: 1660-3397
Discipline: Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: Fulltext
Database: Web of Knowledge
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