Synthesis of bridged piperazines with σ receptor affinity

Bridged piperazines 4 were designed as conformationally restricted piperazine σ receptor ligands. The chiral pool synthesis started from ( S)-glutamate, which was transformed in five reaction steps into the piperazinediones 5 bearing a propionic acid ester side chain. A two-step Dieckmann analogous...

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Bibliographic details
Volume: 42
Main Author: Weigl, Manuela
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: Oxford Elsevier Masson SAS 2007
Elsevier
published in: European journal of medicinal chemistry Vol. 42; no. 10; pp. 1247 - 1262
Data of publication: 2007
ISSN: 0223-5234
1768-3254
EISSN: 1768-3254
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
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Online Access: available in Bonn?
CODEN: EJMCA5
Database: Pascal-Francis
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