Chemoselective Synthesis of 5-Alkylamino-1H-pyrazole-4-carbaldehydes by Cesium- and Copper-Mediated Amination

Microwave‐assisted synthesis of new 5‐alkylamino‐pyrazole‐4‐carbaldehydes was performed efficiently, with yields up to 99 % and short reaction times. Nucleophilic substitution of primary alkylamines with activated 5‐chloro‐1‐(2‐pyridyl)pyrazole‐4‐carbaldehyde was mediated by the “cesium effect”. The...

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Bibliographic details
Volume: 2015
Main Author: Orrego-Hernández, Jessica
Cobo, Justo
Portilla, Jaime
Format: Journal Article
Language: English
Zielgruppe: Academic
Place of publication: Weinheim WILEY-VCH Verlag 01.08.2015
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published in: European journal of organic chemistry Vol. 2015; no. 23; pp. 5064 - 5069
Data of publication: 2015-08
ISSN: 1434-193X
EISSN: 1099-0690
Discipline: Chemistry
Online Access: available in Bonn?
Database: Istex
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