Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists

To determine the eutomers of potent GluN2B‐selective N‐methyl‐d‐aspartate (NMDA) receptor antagonists with a 3‐benzazepine scaffold, 7‐benzyloxy‐3‐(4‐phenylbutyl)‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepin‐1‐ols (S)‐2 and (R)‐2 were separated by chiral HPLC. Hydrogenolysis and subsequent methylation of the...

Full description

Saved in:
Bibliographic details
Volume: 13
Main Author: Börgel, Frederik
Szermerski, Marina
Schreiber, Julian A
Temme, Louisa
Strutz‐Seebohm, Nathalie
Lehmkuhl, Kirstin
Schepmann, Dirk
Ametamey, Simon M
Seebohm, Guiscard
Schmidt, Thomas J
Wünsch, Bernhard
Format: Journal Article
Language: English
Zielgruppe: Academic
Place of publication: Germany Wiley Subscription Services, Inc 10.08.2018
published in: ChemMedChem Vol. 13; no. 15; pp. 1580 - 1587
ORCID: 0000-0002-9030-8417
Data of publication: August 10, 2018
ISSN: 1860-7179
1860-7187
EISSN: 1860-7187
Discipline: Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: available in Bonn?
Database: PubMed
CrossRef
Academic OneFile (A&I only)
MEDLINE - Academic
Database information Databases - DBIS