Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines

[Display omitted] Amantadine (1) exerts its anti-Parkinson effects by inhibition of the NMDA associated cation channel and its antiviral activity by inhibition of the M2 protein channel of influenza A viruses. Herein the synthesis, NMDA receptor affinity and anti-influenza activity of analogous prop...

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Bibliographic details
Volume: 23
Main Author: Torres-Gómez, Héctor
Lehmkuhl, Kirstin
Frehland, Bastian
Daniliuc, Constantin
Schepmann, Dirk
Ehrhardt, Christina
Wünsch, Bernhard
Format: Journal Article
Language: English
Zielgruppe: Academic
Place of publication: England Elsevier Ltd 01.08.2015
Elsevier B.V
Elsevier BV
published in: Bioorganic & medicinal chemistry Vol. 23; no. 15; pp. 4277 - 4285
Data of publication: 2015-08-01
ISSN: 0968-0896
1464-3391
EISSN: 1464-3391
Discipline: Medicine
Anatomy & Physiology
Chemistry
Subjects:
Online Access: available in Bonn?
Database: Medline
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MEDLINE
MEDLINE
PubMed
CrossRef
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MEDLINE - Academic
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