A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast

Multiple lines of evidence show that soluble oligomer forms of amyloid β protein (Aβ42) are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer's disease. Although many studies have used mammalian cells to investigate oligo...

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Bibliographic details

Volume:	15
Main Author:	Bharadwaj, Prashant Martins, Ralph
Format:	Journal Article
Language:	English
Place of publication:	Mumbai Wolters Kluwer India Pvt. Ltd 01.10.2020 Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications
published in:	Neural regeneration research Vol. 15; no. 10; pp. 1931 - 1936
Data of publication:	20201001
ISSN:	1673-5374 1876-7958
EISSN:	1876-7958
Discipline:	Anatomy & Physiology
Subjects:	Proteins Brain Yeast Peptides Nitrogen Autophagy Insulin Experiments Apoptosis alzheimer’s disease; amyloid toxicity; autophagy; aβ42 oligomer; high-throughput screening; latrepirdine; neuroprotection; yeast model United States--US
Online Access:	Fulltext
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