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A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast

Multiple lines of evidence show that soluble oligomer forms of amyloid β protein (Aβ42) are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer's disease. Although many studies have used mammalian cells to investigate oligo...

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Bibliographic details
Volume: 15
Main Author: Bharadwaj, Prashant
Martins, Ralph
Format: Journal Article
Language: English
Place of publication: Mumbai Wolters Kluwer India Pvt. Ltd 01.10.2020
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
published in: Neural regeneration research Vol. 15; no. 10; pp. 1931 - 1936
Data of publication: 20201001
ISSN: 1673-5374
1876-7958
EISSN: 1876-7958
Discipline: Anatomy & Physiology
Bibliography: Author contributions: Conceptualization, methodology, data acquisition, original draft preparation: PB; writing and review and funding acquisition: RM, PB. Both authors approved the final version of the paper.
Subjects:
Proteins
Brain
Yeast
Peptides
Nitrogen
Autophagy
Insulin
Experiments
Apoptosis
autophagy
neuroprotection
yeast model
Aß42 oligomer
high-throughput screening
amyloid toxicity
Alzheimer's disease
latrepirdine
alzheimer’s disease; amyloid toxicity; autophagy; aβ42 oligomer; high-throughput screening; latrepirdine; neuroprotection; yeast model
United States--US
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