Expression of σ receptors of human urinary bladder tumor cells (RT-4 cells) and development of a competitive receptor binding assay for the determination of ligand affinity to human σ 2 receptors

A selective competitive binding assay for the determination of the affinity of compounds to the human σ 2 receptor using 96-well multiplates and a solid state scintillator was developed. In the assay system, [ 3H]ditolylguanidine (DTG) was used as radioligand and membrane homogenates from human RT-4...

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Bibliographic details
Volume: 55
Main Author: Schepmann, Dirk
Lehmkuhl, Kirstin
Brune, Stefanie
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: Elsevier B.V 2011
published in: Journal of pharmaceutical and biomedical analysis Vol. 55; no. 5; pp. 1136 - 1141
Data of publication: 2011
ISSN: 0731-7085
1873-264X
EISSN: 1873-264X
Discipline: Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: available in Bonn?
Database: Database information not found
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