Diastereoselective Synthesis of Cyclic Five-Membered trans,trans-Configured Nitrodiols by Double Henry Reaction of 1,4-Dialdehydes

Conformationally constrained perhydroquinoxalines 4 show high κ receptor affinity, selectivity over related receptors and full agonistic activity. Since the κ affinity can be correlated with the dihedral angle of the ethylenediamine pharmacophore (4a: 55°/71°), the dihedral angles of the postulated...

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Bibliographic details
Volume: 348
Main Author: Fröhlich, Janine
Lehmkuhl, Kirstin
Fröhlich, Roland
Wünsch, Bernhard
Format: Journal Article
Language: English, German
Zielgruppe: Academic
Place of publication: Germany Blackwell Publishing Ltd 01.08.2015
Wiley Subscription Services, Inc
published in: Archiv der Pharmazie (Weinheim) Vol. 348; no. 8; pp. 589 - 594
Data of publication: 2015-08
ISSN: 0365-6233
1521-4184
EISSN: 1521-4184
Discipline: Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: Fulltext
Database: Istex
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